ID   STRBP_PONAB             Reviewed;         672 AA.
AC   Q5R6Y5;
DT   06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 74.
DE   RecName: Full=Spermatid perinuclear RNA-binding protein;
GN   Name=STRBP;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in spermatogenesis and sperm function. Plays a role
CC       in regulation of cell growth. Binds to double-stranded DNA and RNA.
CC       Binds most efficiently to poly(I:C) RNA than to poly(dI:dC) DNA. Binds
CC       also to single-stranded poly(G) RNA. Binds non-specifically to the mRNA
CC       PRM1 3'-UTR and adenovirus VA RNA (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with EIF2AK2. Associates with microtubules; it is
CC       unsure whether such interaction is direct or indirect. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Microtubule-
CC       associated that localizes to the manchette in developing spermatids.
CC       {ECO:0000250}.
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DR   EMBL; CR860341; CAH92475.1; -; mRNA.
DR   RefSeq; NP_001126458.1; NM_001132986.1.
DR   AlphaFoldDB; Q5R6Y5; -.
DR   SMR; Q5R6Y5; -.
DR   STRING; 9601.ENSPPYP00000021950; -.
DR   GeneID; 100173445; -.
DR   KEGG; pon:100173445; -.
DR   CTD; 55342; -.
DR   eggNOG; KOG3792; Eukaryota.
DR   InParanoid; Q5R6Y5; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   CDD; cd19909; DSRM_STRBP_rpt1; 1.
DR   Gene3D; 3.30.460.10; -; 1.
DR   InterPro; IPR014720; dsRBD_dom.
DR   InterPro; IPR006561; DZF_dom.
DR   InterPro; IPR043519; NT_sf.
DR   InterPro; IPR030446; STRBP.
DR   InterPro; IPR044472; STRBP_DSRM_1.
DR   PANTHER; PTHR45762:SF1; PTHR45762:SF1; 3.
DR   Pfam; PF00035; dsrm; 2.
DR   Pfam; PF07528; DZF; 1.
DR   SMART; SM00358; DSRM; 2.
DR   SMART; SM00572; DZF; 1.
DR   PROSITE; PS50137; DS_RBD; 2.
DR   PROSITE; PS51703; DZF; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Developmental protein; Differentiation; DNA-binding;
KW   Methylation; Reference proteome; Repeat; RNA-binding; Spermatogenesis.
FT   CHAIN           1..672
FT                   /note="Spermatid perinuclear RNA-binding protein"
FT                   /id="PRO_0000274919"
FT   DOMAIN          5..363
FT                   /note="DZF"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01040"
FT   DOMAIN          387..453
FT                   /note="DRBM 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00266"
FT   DOMAIN          510..576
FT                   /note="DRBM 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00266"
FT   REGION          52..73
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          349..371
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          466..499
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        476..499
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         612
FT                   /note="Asymmetric dimethylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:Q91WM1"
FT   MOD_RES         617
FT                   /note="Asymmetric dimethylarginine"
FT                   /evidence="ECO:0000250|UniProtKB:Q91WM1"
SQ   SEQUENCE   672 AA;  73622 MW;  3CF65F578A429FBC CRC64;
     MRSIRSFAND DRHVMVKHST IYPSPEELEA VQNMVSTVEC ALKHVSDWLD ETNKGTKTEG
     ETEVKKDEAG ENYSKDQGGR TLCGVMRIGL VAKGLLIKDD MDLELVLMCK DKPTETLLNT
     VKDNLPIQIQ KLTEEKYQVE QCVNEASIII RNTKEPTLTL KVILTSPLIR DELEKKDGEN
     VSMKDPPDLL DRQKCLNALA SLRHAKWFQA RANGLKSCVI VLRILRDLCN RVPTWAPLKG
     WPLELICEKS IGTCNRPLGA GEALRRVMEC LASGILLPGG PGLHDPCERD PTDALSYMTI
     QQKEDITHSA QHALRLSAFG QIYKVLEMDP LPSSKPFQKY SWSVTDKEGA GSSALKRPFE
     DGLGDDKDPN KKMKRNLRKI LDSKAIDLMN ALMRLNQIRP GLQYKLLSQS GPVHAPVFTM
     SVDVDGTTYE ASGPSKKTAK LHVAVKVLQA MGYPTGFDAD IECMSSDEKS DNESKNETVS
     SNSSNNTGNS TTETSSTLEV RTQGPILTAS GKNPVMELNE KRRGLKYELI SETGGSHDKR
     FVMEVEVDGQ KFRGAGPNKK VAKASAALAA LEKLFSGPNA ANNKKKKIIP QAKGVVNTAV
     SAAVQAVRGR GRGTLTRGAF VGAAAAPGYI APGYGTPYGY STAAPAYGLP KRMVLLPVMK
     FPTYPVPHYS FF