STRCL_HUMAN
ID STRCL_HUMAN Reviewed; 1772 AA.
AC A6NGW2;
DT 10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-JUL-2007, sequence version 1.
DT 25-MAY-2022, entry version 74.
DE RecName: Full=Putative stereocilin-like protein;
DE AltName: Full=Stereocilin pseudogene 1;
DE Flags: Precursor;
GN Name=STRCP1; Synonyms=STRCP;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16572171; DOI=10.1038/nature04601;
RA Zody M.C., Garber M., Sharpe T., Young S.K., Rowen L., O'Neill K.,
RA Whittaker C.A., Kamal M., Chang J.L., Cuomo C.A., Dewar K.,
RA FitzGerald M.G., Kodira C.D., Madan A., Qin S., Yang X., Abbasi N.,
RA Abouelleil A., Arachchi H.M., Baradarani L., Birditt B., Bloom S.,
RA Bloom T., Borowsky M.L., Burke J., Butler J., Cook A., DeArellano K.,
RA DeCaprio D., Dorris L. III, Dors M., Eichler E.E., Engels R., Fahey J.,
RA Fleetwood P., Friedman C., Gearin G., Hall J.L., Hensley G., Johnson E.,
RA Jones C., Kamat A., Kaur A., Locke D.P., Madan A., Munson G., Jaffe D.B.,
RA Lui A., Macdonald P., Mauceli E., Naylor J.W., Nesbitt R., Nicol R.,
RA O'Leary S.B., Ratcliffe A., Rounsley S., She X., Sneddon K.M.B.,
RA Stewart S., Sougnez C., Stone S.M., Topham K., Vincent D., Wang S.,
RA Zimmer A.R., Birren B.W., Hood L., Lander E.S., Nusbaum C.;
RT "Analysis of the DNA sequence and duplication history of human chromosome
RT 15.";
RL Nature 440:671-675(2006).
RN [2]
RP IDENTIFICATION.
RX PubMed=12825070; DOI=10.1038/sj.ejhg.5200991;
RA Avidan N., Tamary H., Dgany O., Cattan D., Pariente A., Thulliez M.,
RA Borot N., Moati L., Barthelme A., Shalmon L., Krasnov T., Ben-Asher E.,
RA Olender T., Khen M., Yaniv I., Zaizov R., Shalev H., Delaunay J.,
RA Fellous M., Lancet D., Beckmann J.S.;
RT "CATSPER2, a human autosomal nonsyndromic male infertility gene.";
RL Eur. J. Hum. Genet. 11:497-502(2003).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the stereocilin family. {ECO:0000305}.
CC -!- CAUTION: Could be the product of a pseudogene. According to
CC PubMed:12825070, no evidence has been tendered concerning the existence
CC of this protein. {ECO:0000305}.
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DR EMBL; AC011330; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC018512; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; A6NGW2; -.
DR GlyGen; A6NGW2; 5 sites, 1 N-linked glycan (1 site).
DR BioMuta; HGNC:33915; -.
DR MassIVE; A6NGW2; -.
DR PeptideAtlas; A6NGW2; -.
DR PRIDE; A6NGW2; -.
DR GeneCards; STRCP1; -.
DR HGNC; HGNC:33915; STRCP1.
DR neXtProt; NX_A6NGW2; -.
DR InParanoid; A6NGW2; -.
DR Pharos; A6NGW2; Tdark.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; A6NGW2; protein.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0060091; C:kinocilium; IBA:GO_Central.
DR GO; GO:0032426; C:stereocilium tip; IBA:GO_Central.
DR GO; GO:0007160; P:cell-matrix adhesion; IBA:GO_Central.
DR InterPro; IPR026061; Stereocilin.
DR InterPro; IPR026664; Stereocilin-rel.
DR PANTHER; PTHR23412; PTHR23412; 1.
DR PANTHER; PTHR23412:SF14; PTHR23412:SF14; 1.
PE 5: Uncertain;
KW Glycoprotein; Reference proteome; Secreted; Signal.
FT SIGNAL 1..25
FT /evidence="ECO:0000255"
FT CHAIN 26..1772
FT /note="Putative stereocilin-like protein"
FT /id="PRO_0000339348"
FT CARBOHYD 65
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 427
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 476
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 565
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1772 AA; 192437 MW; A96B4DA8FC868F97 CRC64;
MALSLWPLLL LLLLLLLLSF AVTLAPTGPH SLDPGLSFLK SLLSTLDQAP QGSLSRSRFF
TFLANISSSF EPGRMGEGPV GEPPPLQPPA LRLHDFLVTL RGSPDWEPML GLLGDMLALL
GQEQTPRDFL VHQAGVLGGL VEVLLGALVP GGPPTPTQPP CTRDGPSDCV LAADWLPSLL
LLLEGTRWQA LVQVQPSVDP TNATGLDGRE AAPHFLQGLL GLLTPTGELG SKEALWGGLL
RTVGAPLYAA FQEGLLRVTH SLQDEVFSIL GQPEPDTNGQ CQGGNLQQLL LWGVRHNLSW
DVQALGFLSG SPPPPPALLH CLSTGVPLPR ASQPSAHISP RQRRAITVEA LCENHLGPAP
PYSISNFSIH LLCQHTKPAT PQPHPSTTAI CQTAVWYAVS WAPGAQGWLQ ACHDQFPDEF
LDAICSNLSF SALSGSNRRL VKRLCAGLLP PPTSCPEGLP PVPLTPDIFW GCFLENETLW
AERLCGEASL QAVPPSNQAW VQHVCQGPTP DVTASPPCHI GPCGERCPDG GSFLVMVCAN
DTMYEVLVPF WPWLAGQCRI SRGGNDTCFL EGLLGPLLPS LPPLGPSPLC LTPGPFLLGM
LSQLPRCQSS VPALAHPTRL HYLLRLLTFL LGPGAGGAEA QGMLGRALLL SSLPDNCSFW
DAFRPEGRRS VLRTIGEYLE QDEEQPTPSG FEPTVNPSSG ISKMELLACF SPVLWDLLQR
EKSVWALQIL VQAYLHMPPE NLQQLVLSAE REAAQGFLTL MLQGKLQGKL QVPPSEEQAL
GRLTALLLQR YPRLTSQLFI DLSPLIPFLA VSDLMRFPPS LLANDSVLAA IRDYSPGMRP
EQKEALAKRL LAPELFGEVP AWPQELLWAV LPLLPHLPLE NFLQLSPHQI QALEDSWPAA
GLGPGHARHV LRSLVNQSVQ DGEEQVRRLG PLACFLSPEE LQSLVPLSDP TGPVERGLLE
CAANGTLSPE GRVAYELLGV LRSSGGAVLS PRELRVWAPL FSQLGLRFLQ ELSEPQLRAM
LPVLQGTSVT PAQAVLLLGR LLPRHDLSLE ELCSLHLLLP GLSPQTLQAI PRRVLVGACS
CLAPELSRLS ACQTAALLQT FRVKDGVKNM GTTGAGPAVC IPGQQPIPTT WPDCLLPLLP
LKLLQLDSLA LLANRRRYWE LPWSEQQAQF LWKKMQVPTN LTLRNLQALG TLAGGMSCEF
LQQINSMVDF LEVVHMIYQL PTRVRGSLRA CIWAELQRRM AMPEPEWTTV GPELNGLDSK
LLLDLPIQLM DRLSNESIML VVELVQRAPE QLLALTPLHQ AALAERALQN LAPKETPVSG
EVLETLGPLV GFLGTESTRQ IPLQILLSHL SFCLGETFAT ELGWLLLQES VLGKPELWSQ
DEVEQAGRLV FTLSTEAISL IPREALGPET LERLLEKQQS WEQSRVGQLC RGPQLAAKKA
ALVAGVVRPA AEDLPEPVPN CADVRGTFPA ACSATQIAEM ELSDFKDCLT LFAGDPGLGP
EEPRAAMGKA KWLWGPPRGF GPEQILQLGR LLIGLGDQEL QELILVDWGV LSTLGQIDGW
SSTQLRIVVS SFLRQSGRHV SHLDFVHLTA LGYTLCGLRP EELQHISSWE FSQAALFLGT
LHLQCSEEQL EFLAHLFVLP GGFGPISNWG PEIFTEIGTI AAGIPDLALS ALLRGQIQGV
TPLAISVIPP PKFAVVFSPI QLSSLASAQA VAVTPEQMAF LSPEQRRAVA WAQHEGKESP
EQQGRSTAWG LQDWSRPSWS LVLTISFLGH LL
