STRC_MOUSE
ID STRC_MOUSE Reviewed; 1809 AA.
AC Q8VIM6; A2ARP7;
DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 122.
DE RecName: Full=Stereocilin;
DE Flags: Precursor;
GN Name=Strc;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION, AND TISSUE SPECIFICITY.
RC STRAIN=BALB/cJ; TISSUE=Inner ear;
RX PubMed=11687802; DOI=10.1038/ng726;
RA Verpy E., Masmoudi S., Zwaenepoel I., Leibovici M., Hutchin T.P.,
RA Del Castillo I., Nouaille S., Blanchard S., Laine S., Popot J.-L.,
RA Moreno F., Mueller R.F., Petit C.;
RT "Mutations in a new gene encoding a protein of the hair bundle cause non-
RT syndromic deafness at the DFNB16 locus.";
RL Nat. Genet. 29:345-349(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [3]
RP FUNCTION, TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX PubMed=21165971; DOI=10.1002/cne.22509;
RA Verpy E., Leibovici M., Michalski N., Goodyear R.J., Houdon C., Weil D.,
RA Richardson G.P., Petit C.;
RT "Stereocilin connects outer hair cell stereocilia to one another and to the
RT tectorial membrane.";
RL J. Comp. Neurol. 519:194-210(2011).
CC -!- FUNCTION: Essential to the formation of horizontal top connectors
CC between outer hair cell stereocilia. {ECO:0000269|PubMed:21165971}.
CC -!- SUBCELLULAR LOCATION: Cell surface. Cell projection, kinocilium. Cell
CC projection, stereocilium.
CC -!- TISSUE SPECIFICITY: Strongly expressed in the inner ear, detected in
CC the testis, and barely detected in the eye. Detected in the six sensory
CC areas of the inner ear by immunofluorescence. Expressed only in the
CC sensory hair cells and associated with the stereocilia, the stiff
CC microvilli forming the structure for mechanoreception of sound
CC stimulation. {ECO:0000269|PubMed:11687802,
CC ECO:0000269|PubMed:21165971}.
CC -!- SIMILARITY: Belongs to the stereocilin family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF375593; AAL35321.1; -; mRNA.
DR EMBL; AL845466; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS16641.1; -.
DR RefSeq; NP_536707.2; NM_080459.2.
DR RefSeq; XP_006498797.1; XM_006498734.2.
DR AlphaFoldDB; Q8VIM6; -.
DR SMR; Q8VIM6; -.
DR STRING; 10090.ENSMUSP00000039378; -.
DR GlyGen; Q8VIM6; 15 sites.
DR iPTMnet; Q8VIM6; -.
DR PhosphoSitePlus; Q8VIM6; -.
DR PaxDb; Q8VIM6; -.
DR PRIDE; Q8VIM6; -.
DR ProteomicsDB; 254601; -.
DR Antibodypedia; 56334; 18 antibodies from 8 providers.
DR Ensembl; ENSMUST00000038389; ENSMUSP00000039378; ENSMUSG00000033498.
DR GeneID; 140476; -.
DR KEGG; mmu:140476; -.
DR UCSC; uc008lyw.1; mouse.
DR CTD; 161497; -.
DR MGI; MGI:2153816; Strc.
DR VEuPathDB; HostDB:ENSMUSG00000033498; -.
DR eggNOG; ENOG502QTHC; Eukaryota.
DR GeneTree; ENSGT00950000182957; -.
DR HOGENOM; CLU_001286_0_0_1; -.
DR InParanoid; Q8VIM6; -.
DR OMA; HLICGLY; -.
DR OrthoDB; 86428at2759; -.
DR TreeFam; TF330914; -.
DR BioGRID-ORCS; 140476; 1 hit in 74 CRISPR screens.
DR PRO; PR:Q8VIM6; -.
DR Proteomes; UP000000589; Chromosome 2.
DR RNAct; Q8VIM6; protein.
DR Bgee; ENSMUSG00000033498; Expressed in utricle of membranous labyrinth and 11 other tissues.
DR ExpressionAtlas; Q8VIM6; baseline and differential.
DR Genevisible; Q8VIM6; MM.
DR GO; GO:0009986; C:cell surface; IBA:GO_Central.
DR GO; GO:0060091; C:kinocilium; IDA:UniProtKB.
DR GO; GO:0032426; C:stereocilium tip; IDA:UniProtKB.
DR GO; GO:0060088; P:auditory receptor cell stereocilium organization; IMP:UniProtKB.
DR GO; GO:0007160; P:cell-matrix adhesion; IBA:GO_Central.
DR GO; GO:0050910; P:detection of mechanical stimulus involved in sensory perception of sound; IMP:MGI.
DR GO; GO:0007605; P:sensory perception of sound; ISO:MGI.
DR InterPro; IPR026061; Stereocilin.
DR InterPro; IPR026664; Stereocilin-rel.
DR PANTHER; PTHR23412; PTHR23412; 1.
DR PANTHER; PTHR23412:SF14; PTHR23412:SF14; 1.
PE 2: Evidence at transcript level;
KW Cell projection; Cilium; Glycoprotein; Hearing; Reference proteome; Signal.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..1809
FT /note="Stereocilin"
FT /id="PRO_0000022427"
FT REGION 376..426
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 376..425
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 63
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 200
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 295
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 352
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 364
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 467
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 516
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 580
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 605
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 696
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 860
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 952
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1000
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1213
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1308
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 477..479
FT /note="SRP -> NRR (in Ref. 1; AAL35321)"
FT /evidence="ECO:0000305"
FT CONFLICT 622
FT /note="P -> L (in Ref. 1; AAL35321)"
FT /evidence="ECO:0000305"
FT CONFLICT 937
FT /note="D -> G (in Ref. 1; AAL35321)"
FT /evidence="ECO:0000305"
FT CONFLICT 1632
FT /note="V -> L (in Ref. 1; AAL35321)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 1809 AA; 196347 MW; FEDE974426C44F6E CRC64;
MALSLQPQLL LLLSLLPQEV TSAPTGPQSL DAGLSLLKSF VATLDQAPQR SLSQSRFSAF
LANISSSFQL GRMGEGPVGE PPPLQPPALR LHDFLVTLRG SPDWEPMLGL LGDVLALLGQ
EQTPRDFLVH QAGVLGGLVE ALLGALVPGG PPAPTRPPCT RDGPSDCVLA ADWLPSLMLL
LEGTRWQALV QLQPSVDPTN ATGLDGREPA PHFLQGLLGL LTPAGELGSE EALWGGLLRT
VGAPLYAAFQ EGLLRVTHSL QDEVFSIMGQ PEPDASGQCQ GGNLQQLLLW GMRNNLSWDA
RALGFLSGSP PPPPALLHCL SRGVPLPRAS QPAAHISPRQ RRAISVEALC ENHSGPEPPY
SISNFSIYLL CQHIKPATPR PPPTTPRPPP TTPQPPPTTT QPIPDTTQPP PVTPRPPPTT
PQPPPSTAVI CQTAVWYAVS WAPGARGWLQ ACHDQFPDQF LDMICGNLSF SALSGPSRPL
VKQLCAGLLP PPTSCPPGLI PVPLTPEIFW GCFLENETLW AERLCVEDSL QAVPPRNQAW
VQHVCRGPTL DATDFPPCRV GPCGERCPDG GSFLLMVCAN DTLYEALVPF WAWLAGQCRI
SRGGNDTCFL EGMLGPLLPS LPPLGPSPLC LAPGPFLLGM LSQLPRCQSS VPALAHPTRL
HYLLRLLTFL LGPGTGGAET QGMLGQALLL SSLPDNCSFW DAFRPEGRRS VLRTVGEYLQ
REEPTPPGLD SSLSLGSGMS KMELLSCFSP VLWDLLQREK SVWALRTLVK AYLRMPPEDL
QQLVLSAEME AAQGFLTLML RSWAKLKVQP SEEQAMGRLT ALLLQRYPRL TSQLFIDMSP
LIPFLAVPDL MRFPPSLLAN DSVLAAIRDH SSGMKPEQKE ALAKRLLAPE LFGEVPDWPQ
ELLWAALPLL PHLPLESFLQ LSPHQIQALE DSWPVADLGP GHARHVLRSL VNQSMEDGEE
QVLRLGSLAC FLSPEELQSL VPLSDPMGPV EQGLLECAAN GTLSPEGRVA YELLGVLRSS
GGTVLSPREL RVWAPLFPQL GLRFLQELSE TQLRAMLPAL QGASVTPAQA VLLFGRLLPK
HDLSLEELCS LHPLLPGLSP QTLQAIPKRV LVGACSCLGP ELSRLSACQI AALLQTFRVK
DGVKNMGAAG AGSAVCIPGQ PTTWPDCLLP LLPLKLLQLD AAALLANRRL YRQLPWSEQQ
AQFLWKKMQV PTNLSLRNLQ ALGNLAGGMT CEFLQQISSM VDFLDVVHML YQLPTGVRES
LRACIWTELQ RRMTMPEPEL TTLGPELSEL DTKLLLDLPI QLMDRLSNDS IMLVVEMVQG
APEQLLALTP LHQTALAERA LKNLAPKETP ISKEVLETLG PLVGFLGIES TRRIPLPILL
SHLSQLQGFC LGETFATELG WLLLQEPVLG KPELWSQDEI EQAGRLVFTL SAEAISSIPR
EALGPETLER LLGKHQSWEQ SRVGHLCGES QLAHKKAALV AGIVHPAAEG LQEPVPNCAD
IRGTFPAAWS ATQISEMELS DFEDCLSLFA GDPGLGPEEL RAAMGKAKQL WGPPRGFRPE
QILQLGRLLI GLGERELQEL TLVDWGVLSS LGQIDGWSSM QLRAVVSSFL RQSGRHVSHL
DFIYLTALGY TVCGLRPEEL QHISSWEFSQ AALFLGSLHL PCSEEQLEVL AYLLVLPGGF
GPVSNWGPEI FTEIGTIAAG IPDLALSALL RGQIQGLTPL AISVIPAPKF AVVFNPIQLS
SLTRGQAVAV TPEQLAYLSP EQRRAVAWAQ HEGKEIPEQL GRNSAWGLYD WFQASWALAL
PVSIFGHLL
