ID   STRF_STRGR              Reviewed;         281 AA.
AC   P09397; Q54254;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1992, sequence version 2.
DT   25-MAY-2022, entry version 62.
DE   RecName: Full=Streptomycin biosynthesis protein StrF;
GN   Name=strF;
OS   Streptomyces griseus.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1911;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=N2-3-11;
RX   PubMed=1654502; DOI=10.1007/bf00260640;
RA   Mansouri K., Piepersberg W.;
RT   "Genetics of streptomycin production in Streptomyces griseus: nucleotide
RT   sequence of five genes, strFGHIK, including a phosphatase gene.";
RL   Mol. Gen. Genet. 228:459-469(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 48-96.
RC   STRAIN=ATCC 23345 / DSM 40236 / JCM 4644 / NBRC 12875 / NCIMB 13023 / NRRL
RC   B-2682 / VKM Ac-800 / IMRU 3463;
RX   PubMed=3029728; DOI=10.1093/nar/15.4.1819;
RA   Tohyama H., Okami Y., Umezawa H.;
RT   "Nucleotide sequence of the streptomycinphosphotransferase and
RT   amidinotransferase genes from Streptomyces griseus.";
RL   Nucleic Acids Res. 15:1819-1833(1987).
CC   -!- FUNCTION: May be involved in the formation of N-methyl-L-glucosamine.
CC   -!- PATHWAY: Antibiotic biosynthesis; streptomycin biosynthesis.
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DR   EMBL; Y00459; CAA68518.1; -; Genomic_DNA.
DR   EMBL; X05045; CAA28719.1; -; Genomic_DNA.
DR   PIR; S17776; S17776.
DR   RefSeq; WP_003970241.1; NZ_UAVD01000010.1.
DR   AlphaFoldDB; P09397; -.
DR   GeneID; 6214274; -.
DR   OMA; AYNAMFD; -.
DR   UniPathway; UPA00066; -.
DR   GO; GO:0019872; P:streptomycin biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.90.550.10; -; 1.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   SUPFAM; SSF53448; SSF53448; 1.
PE   4: Predicted;
KW   Antibiotic biosynthesis; Streptomycin biosynthesis.
FT   CHAIN           1..281
FT                   /note="Streptomycin biosynthesis protein StrF"
FT                   /id="PRO_0000072283"
FT   CONFLICT        96
FT                   /note="S -> I (in Ref. 2; CAA28719)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   281 AA;  31726 MW;  82456C5119B6387C CRC64;
     MIGYGVCVGP GTLFERTCLP GIERVRAPGS PVFTMRNQRS LFSAYNAMFD QAAANSDITG
     LVMLHDDVEL RKNPAEVAQS VFEDDSVGML GSVGGSDTVS LAWWNERETR RGRVTDYDKV
     HDYGSDRYEV EAVDDVILCV NRWTIENIRF PEGHYRGFEG LGVILATLVR AAGKRVMVQD
     LQDVMHHNDG RGFNGLKDWR HNELRWHREF FDLSPAERLG NHLERLTIPA VPLRLAARRL
     AMRVGGRSHE VSDGETGDPV IDRLVGGWYR QCTRLRGRML V