ID   STRH_STRGR              Reviewed;         384 AA.
AC   P09399;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   25-MAY-2022, entry version 57.
DE   RecName: Full=dTDP-dihydrostreptose--streptidine-6-phosphate dihydrostreptosyltransferase;
DE            EC=2.4.2.27;
GN   Name=strH;
OS   Streptomyces griseus.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1911;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=N2-3-11;
RX   PubMed=1654502; DOI=10.1007/bf00260640;
RA   Mansouri K., Piepersberg W.;
RT   "Genetics of streptomycin production in Streptomyces griseus: nucleotide
RT   sequence of five genes, strFGHIK, including a phosphatase gene.";
RL   Mol. Gen. Genet. 228:459-469(1991).
CC   -!- FUNCTION: Is probably a dihydrostreptosyl glycosyltransferase, involved
CC       in the first glycosylation step condensing streptidine-6-phosphate and
CC       dihydrostreptose. {ECO:0000250}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=dTDP-L-dihydrostreptose + streptidine 6-phosphate = dTDP +
CC         H(+) + O-(1->4)-alpha-L-dihydrostreptosyl-streptidine 6-phosphate;
CC         Xref=Rhea:RHEA:24392, ChEBI:CHEBI:15378, ChEBI:CHEBI:57631,
CC         ChEBI:CHEBI:58082, ChEBI:CHEBI:58369, ChEBI:CHEBI:60106; EC=2.4.2.27;
CC   -!- PATHWAY: Antibiotic biosynthesis; streptomycin biosynthesis.
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DR   EMBL; Y00459; CAA68520.1; -; Genomic_DNA.
DR   PIR; S17778; S17778.
DR   RefSeq; WP_012381621.1; NZ_UAVD01000010.1.
DR   AlphaFoldDB; P09399; -.
DR   GeneID; 6214159; -.
DR   OMA; GSHEIFE; -.
DR   UniPathway; UPA00066; -.
DR   GO; GO:0047282; F:dTDP-dihydrostreptose-streptidine-6-phosphate dihydrostreptosyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0019872; P:streptomycin biosynthetic process; IEA:UniProtKB-UniPathway.
PE   3: Inferred from homology;
KW   Antibiotic biosynthesis; Glycosyltransferase; Streptomycin biosynthesis;
KW   Transferase.
FT   CHAIN           1..384
FT                   /note="dTDP-dihydrostreptose--streptidine-6-phosphate
FT                   dihydrostreptosyltransferase"
FT                   /id="PRO_0000072285"
SQ   SEQUENCE   384 AA;  42900 MW;  61BB01FB77222A71 CRC64;
     MVMTSPTRKP SGDVRPDEPL HHLDQPFREF LDGLPADRPP WFCFFSSGLL HVLHHFLRFT
     PERLNCVFIC SGLSKEEAEL RDRMSGGRPV FDMTEQVGSH EIFELLVRNL DRPFGIVDVD
     CFVTETDWFE RCMDGLEPGV AVSGPLSYGP IPLAAPPFLA LDPRVRPDIE RAIGGTVTPA
     AYSYTAPGPE KEIDGAMVRL IEPHHERALA RVVALEGPRL PFPQGGLVDV LDDGREVRSH
     ERYHHLQNGN EVIRVVFDGL MFYQLMALAA GLRIAHFHSF PGTKVFAPQL VHAGGISYWH
     RLRPSEIAAG INELPWAAHV DALLLEEFNR RADVPASYRT RGTRLAANLR RSMVDMAGLR
     DELRAKLDSS GVDVTDPRWA VVLG