ID   STRI_STRGR              Reviewed;         348 AA.
AC   P09400;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   03-AUG-2022, entry version 83.
DE   RecName: Full=Streptomycin biosynthesis protein StrI;
DE            EC=1.-.-.-;
GN   Name=strI;
OS   Streptomyces griseus.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=1911;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=N2-3-11;
RX   PubMed=1654502; DOI=10.1007/bf00260640;
RA   Mansouri K., Piepersberg W.;
RT   "Genetics of streptomycin production in Streptomyces griseus: nucleotide
RT   sequence of five genes, strFGHIK, including a phosphatase gene.";
RL   Mol. Gen. Genet. 228:459-469(1991).
CC   -!- PATHWAY: Antibiotic biosynthesis; streptomycin biosynthesis.
CC   -!- SIMILARITY: Belongs to the Gfo/Idh/MocA family. {ECO:0000305}.
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DR   EMBL; Y00459; CAA68521.1; -; Genomic_DNA.
DR   PIR; S17779; S17779.
DR   RefSeq; WP_012381622.1; NZ_UAVD01000010.1.
DR   AlphaFoldDB; P09400; -.
DR   SMR; P09400; -.
DR   PRIDE; P09400; -.
DR   GeneID; 6214160; -.
DR   OMA; AAPWSWE; -.
DR   UniPathway; UPA00066; -.
DR   GO; GO:0000166; F:nucleotide binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   GO; GO:0019872; P:streptomycin biosynthetic process; IEA:UniProtKB-UniPathway.
DR   InterPro; IPR004104; Gfo/Idh/MocA-like_OxRdtase_C.
DR   InterPro; IPR000683; Gfo/Idh/MocA-like_OxRdtase_N.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   Pfam; PF01408; GFO_IDH_MocA; 1.
DR   Pfam; PF02894; GFO_IDH_MocA_C; 1.
DR   SUPFAM; SSF51735; SSF51735; 1.
PE   3: Inferred from homology;
KW   Antibiotic biosynthesis; NAD; Oxidoreductase; Streptomycin biosynthesis.
FT   CHAIN           1..348
FT                   /note="Streptomycin biosynthesis protein StrI"
FT                   /id="PRO_0000091778"
FT   BINDING         2..32
FT                   /ligand="NAD(+)"
FT                   /ligand_id="ChEBI:CHEBI:57540"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   348 AA;  36710 MW;  B95BCC443EEABDF6 CRC64;
     MRVGIVGAGR MGRLHARTLL ELPDPPDLVV HDVDPDGAHR LAQELAAGTK AQVTVERELA
     DTVTKADAIV VATPATQRRA PLLAAARAGL PVFCEKPLTA DETEAAELVE ALAHTRLHVG
     FQRRCDPEYQ RLRELIAAGE LGRVLLVRCT AFDHRPPADA YEETAGDIFT DCLIHDIDAV
     HWLTGQPTVA VQADGARLLA GSGYDVATAV LTLADGARAV LSASRLDPHG YDHRVEVLGT
     KGSLSVGLDA RTPLRLLGQD GTGCPPGPGA QPAYQDFTDR FEAAYRREVL AFVRTVTEGA
     PSPCTGQEAL RAQRVAAAAG RAARTGTRVE LDPAPHGAPA ALVAGAAR