STRN_DICDI
ID STRN_DICDI Reviewed; 827 AA.
AC Q54J37;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 03-AUG-2022, entry version 98.
DE RecName: Full=Striatin homolog;
GN Name=strn; ORFNames=DDB_G0288327;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Binds calmodulin in a calcium dependent manner. May function
CC as scaffolding or signaling protein (By similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Membrane {ECO:0000250};
CC Peripheral membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the WD repeat striatin family. {ECO:0000305}.
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DR EMBL; AAFI02000111; EAL63260.1; -; Genomic_DNA.
DR RefSeq; XP_636764.1; XM_631672.1.
DR AlphaFoldDB; Q54J37; -.
DR SMR; Q54J37; -.
DR STRING; 44689.DDB0304999; -.
DR PaxDb; Q54J37; -.
DR PRIDE; Q54J37; -.
DR EnsemblProtists; EAL63260; EAL63260; DDB_G0288327.
DR GeneID; 8626567; -.
DR KEGG; ddi:DDB_G0288327; -.
DR dictyBase; DDB_G0288327; strn.
DR eggNOG; KOG0642; Eukaryota.
DR HOGENOM; CLU_009108_2_0_1; -.
DR InParanoid; Q54J37; -.
DR OMA; TSHRLMR; -.
DR PhylomeDB; Q54J37; -.
DR PRO; PR:Q54J37; -.
DR Proteomes; UP000002195; Chromosome 5.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032991; C:protein-containing complex; IEA:UniProt.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0044877; F:protein-containing complex binding; IEA:UniProt.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR013258; Striatin_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF08232; Striatin; 1.
DR Pfam; PF00400; WD40; 4.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS00678; WD_REPEATS_1; 3.
DR PROSITE; PS50082; WD_REPEATS_2; 4.
DR PROSITE; PS50294; WD_REPEATS_REGION; 1.
PE 3: Inferred from homology;
KW Calmodulin-binding; Coiled coil; Cytoplasm; Membrane; Reference proteome;
KW Repeat; WD repeat.
FT CHAIN 1..827
FT /note="Striatin homolog"
FT /id="PRO_0000328309"
FT REPEAT 495..534
FT /note="WD 1"
FT REPEAT 548..593
FT /note="WD 2"
FT REPEAT 610..649
FT /note="WD 3"
FT REPEAT 709..748
FT /note="WD 4"
FT REPEAT 751..790
FT /note="WD 5"
FT REPEAT 797..827
FT /note="WD 6"
FT REGION 99..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 181..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 311..362
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 400..459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 37..109
FT /evidence="ECO:0000255"
FT COMPBIAS 106..123
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 404..459
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 827 AA; 91756 MW; 66741D67263D4C4B CRC64;
MDNQNNNNAL ANGDSQFTMP KVIDYLQNEW LKFEVDRAHW ISEKAELTNR ILKLESERKL
FESHKFDLCR RVKMLEYALQ QERLKNNSLL QQQQKVIEKV EEEEEEDDKI PKNREPPKKS
KDNTTRLIIR KYLREMGYND LIVSKSLQTE FENDSQNIDN DTTNTIDDTN DTTVKTILNL
KDINNNNSNN NNKNQTTTTT TTSPSPSPSP STSTSTSTSS NKTDNTTTTT TNGNGYNSNT
IISPPSSSSS SSSSSSSSSS QSQPQPQLQS SLSELINNTT DLSQSLDSLS SASSGYEYDS
LLDNLKQLDN SSVSSNSGNN SINSSSDSLD TSKQSQEDPN NVTISKQQQQ EQQQQQESDE
QSFNSFNEDI FNKLTANSKG RMKIKGLGNL KNYKKEHMGE EGNLSLPDQN TEEKSTPTTK
SSSSSSSSST GSTRKKKSSS SSSSGSSSSN SNTMNSELMG LGASDLNDIT LDDGSKGGND
SAAPRVWKFK HSLKSHFDGV RSIQFHPNEP IMISASEDNS IKVWNLNHLV PTKKSPSPEI
EPLYTIRGHT GPVFTSEWNQ INGEYSNYQS FFSAGYDMII RQWSLPSSDI DSYLQHGKIL
PYLEKEFIGG HQDGIWDLLS IPNTPNLLSS SADGTVSLWN TTTSEQLYTL QHSNGLSYIP
TSIALPATEN NRKLLTSYND GSILLFDLET QQIISQLKQG SSNNNNNNNN NSQINKIVSH
PFMPLAMTGS EDHKIEFFDL NSNTVVHSMI AHSNSISSLT IDPSGLYIAS CAHDSSIRFW
DISSKTCIQD LNSHRPKYDE SIHCIKYHPN KGYFASGGAD SVIRILN
