STRN_SORMK
ID STRN_SORMK Reviewed; 845 AA.
AC Q70M86; D1ZQH1; F7VZP7;
DT 16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=Striatin Pro11;
GN Name=pro11 {ECO:0000312|EMBL:CAD91916.1}; ORFNames=SMAC_08794;
OS Sordaria macrospora (strain ATCC MYA-333 / DSM 997 / K(L3346) / K-hell).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Sordariales; Sordariaceae; Sordaria.
OX NCBI_TaxID=771870;
RN [1] {ECO:0000305, ECO:0000312|EMBL:CAD91916.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], FUNCTION, AND SUBCELLULAR LOCATION.
RC STRAIN=ATCC MYA-333 / DSM 997 / K(L3346) / K-hell;
RX PubMed=14871953; DOI=10.1128/ec.3.1.232-240.2004;
RA Poeggeler S., Kueck U.;
RT "A WD40 repeat protein regulates fungal cell differentiation and can be
RT replaced functionally by the mammalian homologue striatin.";
RL Eukaryot. Cell 3:232-240(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-333 / DSM 997 / K(L3346) / K-hell;
RX PubMed=20386741; DOI=10.1371/journal.pgen.1000891;
RA Nowrousian M., Stajich J.E., Chu M., Engh I., Espagne E., Halliday K.,
RA Kamerewerd J., Kempken F., Knab B., Kuo H.-C., Osiewacz H.D., Poeggeler S.,
RA Read N.D., Seiler S., Smith K.M., Zickler D., Kueck U., Freitag M.;
RT "De novo assembly of a 40 Mb eukaryotic genome from short sequence reads:
RT Sordaria macrospora, a model organism for fungal morphogenesis.";
RL PLoS Genet. 6:E1000891-E1000891(2010).
CC -!- FUNCTION: Binds calmodulin in a calcium dependent manner. May function
CC as scaffolding or signaling protein (By similarity). Required for the
CC formation of mature fruiting bodies during early sexual development.
CC {ECO:0000250|UniProtKB:O55106, ECO:0000269|PubMed:14871953}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000269|PubMed:14871953};
CC Peripheral membrane protein {ECO:0000269|PubMed:14871953}.
CC -!- SIMILARITY: Belongs to the WD repeat striatin family. {ECO:0000305}.
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DR EMBL; AJ564211; CAD91916.1; -; Genomic_DNA.
DR EMBL; CABT02000015; CCC10996.1; -; Genomic_DNA.
DR RefSeq; XP_003345440.1; XM_003345392.1.
DR AlphaFoldDB; Q70M86; -.
DR SMR; Q70M86; -.
DR STRING; 771870.Q70M86; -.
DR EnsemblFungi; CCC10996; CCC10996; SMAC_08794.
DR GeneID; 10802793; -.
DR KEGG; smp:SMAC_08794; -.
DR VEuPathDB; FungiDB:SMAC_08794; -.
DR eggNOG; KOG0642; Eukaryota.
DR HOGENOM; CLU_009046_0_0_1; -.
DR InParanoid; Q70M86; -.
DR OMA; TSHRLMR; -.
DR OrthoDB; 334070at2759; -.
DR Proteomes; UP000001881; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IDA:UniProtKB.
DR GO; GO:0005516; F:calmodulin binding; IEA:UniProtKB-KW.
DR GO; GO:0030154; P:cell differentiation; IMP:UniProtKB.
DR GO; GO:0000909; P:sporocarp development involved in sexual reproduction; IMP:UniProtKB.
DR Gene3D; 2.130.10.10; -; 2.
DR InterPro; IPR020472; G-protein_beta_WD-40_rep.
DR InterPro; IPR013258; Striatin_N.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR001680; WD40_repeat.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR Pfam; PF08232; Striatin; 1.
DR Pfam; PF00400; WD40; 4.
DR PRINTS; PR00320; GPROTEINBRPT.
DR SMART; SM00320; WD40; 7.
DR SUPFAM; SSF50978; SSF50978; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 2.
DR PROSITE; PS50294; WD_REPEATS_REGION; 2.
PE 3: Inferred from homology;
KW Calmodulin-binding; Coiled coil; Membrane; Reference proteome; Repeat;
KW WD repeat.
FT CHAIN 1..845
FT /note="Striatin Pro11"
FT /id="PRO_0000051235"
FT REPEAT 427..470
FT /note="WD 1"
FT /evidence="ECO:0000255"
FT REPEAT 486..537
FT /note="WD 2"
FT /evidence="ECO:0000255"
FT REPEAT 540..595
FT /note="WD 3"
FT /evidence="ECO:0000255"
FT REPEAT 647..686
FT /note="WD 4"
FT /evidence="ECO:0000255"
FT REPEAT 726..765
FT /note="WD 5"
FT /evidence="ECO:0000255"
FT REPEAT 768..807
FT /note="WD 6"
FT /evidence="ECO:0000255"
FT REPEAT 814..845
FT /note="WD 7"
FT /evidence="ECO:0000255"
FT REGION 97..159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 147..167
FT /note="Calmodulin-binding"
FT /evidence="ECO:0000255"
FT REGION 238..406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 589..632
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 710..737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 46..85
FT /evidence="ECO:0000255"
FT COMPBIAS 97..131
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 238..258
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 295..310
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 335..388
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 611..632
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 845 AA; 90614 MW; 83F5C418AFBA8835 CRC64;
MGTNGVHVSF GAGHEMGGVM GNGSGQPPAT EYTLQGVMRF LQTEWHRHER DRNAWEIEKQ
EMRARIANLE GQARRADATQ KALKRYVSIL EKKVKEQSAA LKSGGKEKGV EDEAEAEDNK
TKLDRSALIQ EKLRPNTKLS GAPNEAENVE IGPPDDESAR NELKTFLDQC QAEFTYLMVT
PANPQPPRES PPLPILDDFR EGEALNQQLE QSYQRSQQSQ IRDLLAQQAA AANATNVAAV
QSQQQQPQQQ QHAVGPRPQT NQPPKGYGEL AQGAPMERSS RGQQLHDILK SGETPDWSAS
MQSQPVEEPT SALSKAPPMV RGDGREPAVP KSASTTDAWD FNESNFQDPN AMPQPTPQQS
FSSRPDTDAF PSAENLTKSP NRGALSHRRK SSSGMARRRS AEHELSLGSL QQKAEGTMFK
FRFGLRGHLD VVRTVIFSGG GSPGEPEICT AGDDGLVKRF HIPDRHIGQR NADGDLDVAA
DFTHRGHSGA VLSLASWSPS PNFSTGGRAQ GDGWIFSGGQ DATIRVWERG RVDPKATLDG
HTDAVWALCV LPTNLGAIFG QTNSHGPPDR ILLVSGAADG TVKVWAVSAP PQLTSPQPGP
GRRGPGGRVR GNSMSSGSAF PSSPQPTTAS NSPFHHTLVH TIKRANSEAS PTCITALSPN
GETFAVSYAD AAIIVYDTRS GEEIGTMASL DTYDGTNNTA VNAVVATTVG LDQTQGPGGE
DESGGGPTGG GRSMAGSGVE GTIISGHEDR YIRFFDANSG QCTYNMLAHP GSVSSLSLSP
DGRELVSAGH DMSLRFWSLE TRSCTQEMTC HRSMRGEGVC AVVWSQDGRW VVSSGGDGMV
KVYAR
