STRO_STRGR
ID STRO_STRGR Reviewed; 259 AA.
AC P29785;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1997, sequence version 2.
DT 25-MAY-2022, entry version 78.
DE RecName: Full=Glucose-1-phosphate thymidylyltransferase;
DE EC=2.7.7.24;
DE AltName: Full=dTDP-glucose synthase;
GN Name=strO;
OS Streptomyces griseus.
OC Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC Streptomyces.
OX NCBI_TaxID=1911;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND SEQUENCE REVISION TO 33.
RC STRAIN=N2-3-11;
RA Ahlert J., Distler J., Mansouri K., Roggel M., Altenbach H.J.,
RA Piepersberg W.;
RL Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-83.
RC STRAIN=N2-3-11;
RX PubMed=1661369; DOI=10.1007/bf00293829;
RA Pissowotzki K., Mansouri K., Piepersberg W.;
RT "Genetics of streptomycin production in Streptomyces griseus: molecular
RT structure and putative function of genes strELMB2N.";
RL Mol. Gen. Genet. 231:113-123(1991).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-glucose 1-phosphate + dTTP + H(+) = diphosphate +
CC dTDP-alpha-D-glucose; Xref=Rhea:RHEA:15225, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37568, ChEBI:CHEBI:57477,
CC ChEBI:CHEBI:58601; EC=2.7.7.24;
CC -!- PATHWAY: Antibiotic biosynthesis; streptomycin biosynthesis.
CC -!- SIMILARITY: Belongs to the inositol monophosphatase superfamily.
CC {ECO:0000305}.
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DR EMBL; Y08763; CAA70009.1; -; Genomic_DNA.
DR EMBL; X62567; CAA44446.1; ALT_SEQ; Genomic_DNA.
DR PIR; S19785; S19785.
DR RefSeq; WP_003970231.1; NZ_UAVD01000010.1.
DR AlphaFoldDB; P29785; -.
DR SMR; P29785; -.
DR GeneID; 6210185; -.
DR OMA; WVESSVC; -.
DR UniPathway; UPA00066; -.
DR GO; GO:0008879; F:glucose-1-phosphate thymidylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0046855; P:inositol phosphate dephosphorylation; IEA:InterPro.
DR GO; GO:0019872; P:streptomycin biosynthetic process; IEA:UniProtKB-UniPathway.
DR InterPro; IPR000760; Inositol_monophosphatase-like.
DR Pfam; PF00459; Inositol_P; 1.
DR PRINTS; PR00377; IMPHPHTASES.
PE 3: Inferred from homology;
KW Antibiotic biosynthesis; Streptomycin biosynthesis; Transferase.
FT CHAIN 1..259
FT /note="Glucose-1-phosphate thymidylyltransferase"
FT /id="PRO_0000072287"
SQ SEQUENCE 259 AA; 27858 MW; D2DA6E0E75AFF28A CRC64;
MTDNDSDVRL AHRLAEIADT LAWEFFGGAP AVRHKSDGSP VSEADLAVEK ALLAVLAAER
PGDAVLTEES GSLGTRSSRR RWILDPIDGT IPFLAGERGW GTHVALEVDE ELRTAVLSRP
TERSRWWAVR GRGAFTSVRG EPLSAARPLR IPSAPLPLEA ARVGGFLMPD SPVEPVRDRM
RWVESSVCLV GDLLEGRVDA VIDEGGHVWD RAPAALLVHE AGGRVDDLRG GGRLDERWLV
YAADGVADGL AGLLRDVGA