STRP1_MACFA
ID STRP1_MACFA Reviewed; 837 AA.
AC Q9GLZ5;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 56.
DE RecName: Full=Striatin-interacting protein 1;
DE AltName: Full=Protein FAM40A;
GN Name=STRIP1; Synonyms=FAM40A; ORFNames=QnpA-18494;
OS Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC Cercopithecidae; Cercopithecinae; Macaca.
OX NCBI_TaxID=9541;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Parietal cortex;
RA Osada N., Hida M., Kusuda J., Tanuma R., Iseki K., Hirai M., Terao K.,
RA Suzuki Y., Sugano S., Hashimoto K.;
RT "Isolation of full-length cDNA clones from macaque brain cDNA libraries.";
RL Submitted (OCT-2000) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Plays a role in the regulation of cell morphology and
CC cytoskeletal organization. Required in the cortical actin filament
CC dynamics and cell shape (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of striatin-interacting phosphatase and kinase
CC (STRIPAK) complex. Interacts with CDC42BPB. Interacts with CTTNBP2NL.
CC {ECO:0000250|UniProtKB:Q5VSL9, ECO:0000250|UniProtKB:Q8C079}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Enriched on the
CC plasma membrane. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the STRIP family. {ECO:0000305}.
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DR EMBL; AB050515; BAB17283.1; -; mRNA.
DR RefSeq; NP_001306531.1; NM_001319602.1.
DR AlphaFoldDB; Q9GLZ5; -.
DR SMR; Q9GLZ5; -.
DR STRING; 9541.XP_005542485.1; -.
DR GeneID; 102140038; -.
DR CTD; 85369; -.
DR eggNOG; KOG3680; Eukaryota.
DR OrthoDB; 1095402at2759; -.
DR Proteomes; UP000233100; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0030866; P:cortical actin cytoskeleton organization; ISS:UniProtKB.
DR GO; GO:0022604; P:regulation of cell morphogenesis; ISS:UniProtKB.
DR InterPro; IPR040185; Far11/STRP.
DR InterPro; IPR021819; Far11/STRP_C.
DR InterPro; IPR012486; Far11/STRP_N.
DR PANTHER; PTHR13239; PTHR13239; 1.
DR Pfam; PF11882; DUF3402; 2.
DR Pfam; PF07923; N1221; 1.
DR SMART; SM01293; DUF3402; 1.
DR SMART; SM01292; N1221; 1.
PE 2: Evidence at transcript level;
KW Acetylation; Cytoplasm; Phosphoprotein; Reference proteome.
FT CHAIN 1..837
FT /note="Striatin-interacting protein 1"
FT /id="PRO_0000187018"
FT REGION 1..66
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 333..423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..33
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..66
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 346..377
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 378..392
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q5VSL9"
FT MOD_RES 59
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5VSL9"
FT MOD_RES 335
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5VSL9"
FT MOD_RES 339
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8C079"
FT MOD_RES 788
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q5VSL9"
SQ SEQUENCE 837 AA; 95537 MW; 58D0D70A953DA2D0 CRC64;
MEPAAGGPGP LIVNNKQPQP PPPPPPATAQ PPPGAPRAGA GLLPGGKARE FNRNQRKDSE
GYSESPDLEF EYADTDKWAA ELSELYSYTE GPEFLMNRKC FEEDFRIHVT DKKWTELDTN
QHRTHAMRLL DGLEVTAREK RLKVARAILY VAQGTFGECS SEAEVQSWMR YNIFLLLEVG
TFNALVELLN MEIDNSAACS SAVRKPAISL ADSTDLRVLL NIMYLIVETV HQECEGDKAE
WRTMRQTFRA ELGSPLYNSE PFAIMLFGMV TKFCSGHAPH FPMKKVLLLL WKTVLCTLGG
FEELQSMKAE KRSILGLPPL PEDSIKVIRN MRAASPPASA SDLIEQQQKR GRREHKALIK
QDNLDAFNER DPYKADDSRE EEEENDDDNS LEGETFPLER DEVMPPPLQH PQTDRLTCPK
GLPWAPKVRE KDIEMFLESS RSKFIGYTLG SDTNTVVGLP RPIHESIKTL KQHKYTSIAE
VQAQMEEEYL RSPLSGGEEE VEQVPAETLY QGLLPSLPQY MIALLKILLA AAPTSKAKTD
SINILADVLP EEMPTTVLQS MKLGVDVNRH KEVIVKAISA VLLLLLKHFK LNHVYQFEYM
AQHLVFANCI PLILKFFNQN IMSYITAKNS ISVLDYPHCV VHELPELTAE SLEAGDSNQF
CWRNLFSCIN LLRILNKLTK WKHSRTMMLV VFKSAPILKR ALKVKQAMMQ LYVLKLLKVQ
TKYLGRQWRK SNMKTMSAIY QKVRHRLNDD WAYGNDLDAR PWDFQAEECA LRANIERFNA
RRYDRAHSNP DFLPVDNCLQ SVLGQRVDLP EDFQMNYDLW LEREVFSKPI SWEELLQ