STRP2_MOUSE
ID STRP2_MOUSE Reviewed; 844 AA.
AC Q8C9H6; Q3TQB7; Q80TI6; Q8C7A2;
DT 19-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Striatin-interacting proteins 2;
DE AltName: Full=Protein FAM40B;
GN Name=Strip2; Synonyms=Fam40b, Kiaa1170, Stripb;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC STRAIN=C57BL/6J; TISSUE=Cerebellum, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 46-844 (ISOFORM 3).
RC TISSUE=Brain;
RX PubMed=12693553; DOI=10.1093/dnares/10.1.35;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S.,
RA Nakajima D., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: II.
RT The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:35-48(2003).
RN [3]
RP IDENTIFICATION IN THE STRIATIN-INTERACTING PHOSPHATASE AND KINASE (STRIPAK)
RP COMPLEX, AND IDENTIFICATION BY MASS SPECTROMETRY.
RX PubMed=18782753; DOI=10.1074/mcp.m800266-mcp200;
RA Goudreault M., D'Ambrosio L.M., Kean M.J., Mullin M.J., Larsen B.G.,
RA Sanchez A., Chaudhry S., Chen G.I., Sicheri F., Nesvizhskii A.I.,
RA Aebersold R., Raught B., Gingras A.C.;
RT "A PP2A phosphatase high density interaction network identifies a novel
RT striatin-interacting phosphatase and kinase complex linked to the cerebral
RT cavernous malformation 3 (CCM3) protein.";
RL Mol. Cell. Proteomics 8:157-171(2009).
RN [4]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-328; SER-339 AND SER-364, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Heart, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Plays a role in the regulation of cell morphology and
CC cytoskeletal organization. Required in the control of cell shape (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of striatin-interacting phosphatase and kinase
CC (STRIPAK) complex. Interacts with CTTNBP2NL (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Note=Enriched in
CC lamellipodia. {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8C9H6-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8C9H6-4; Sequence=VSP_019001, VSP_019002;
CC Name=3;
CC IsoId=Q8C9H6-3; Sequence=VSP_014870;
CC -!- SIMILARITY: Belongs to the STRIP family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK042073; BAC31154.1; -; mRNA.
DR EMBL; AK163706; BAE37467.1; -; mRNA.
DR EMBL; AK122459; BAC65741.1; -; mRNA.
DR CCDS; CCDS19967.1; -. [Q8C9H6-1]
DR CCDS; CCDS85025.1; -. [Q8C9H6-3]
DR RefSeq; NP_001032829.1; NM_001037740.1. [Q8C9H6-3]
DR RefSeq; NP_796178.2; NM_177204.3. [Q8C9H6-1]
DR AlphaFoldDB; Q8C9H6; -.
DR SMR; Q8C9H6; -.
DR BioGRID; 236153; 37.
DR STRING; 10090.ENSMUSP00000036477; -.
DR iPTMnet; Q8C9H6; -.
DR PhosphoSitePlus; Q8C9H6; -.
DR jPOST; Q8C9H6; -.
DR MaxQB; Q8C9H6; -.
DR PaxDb; Q8C9H6; -.
DR PRIDE; Q8C9H6; -.
DR ProteomicsDB; 257501; -. [Q8C9H6-1]
DR ProteomicsDB; 257502; -. [Q8C9H6-4]
DR ProteomicsDB; 257503; -. [Q8C9H6-3]
DR Antibodypedia; 17893; 59 antibodies from 19 providers.
DR Ensembl; ENSMUST00000046028; ENSMUSP00000036477; ENSMUSG00000039629. [Q8C9H6-1]
DR Ensembl; ENSMUST00000151738; ENSMUSP00000119506; ENSMUSG00000039629. [Q8C9H6-3]
DR GeneID; 320609; -.
DR KEGG; mmu:320609; -.
DR UCSC; uc009bem.1; mouse. [Q8C9H6-1]
DR UCSC; uc009beo.1; mouse. [Q8C9H6-3]
DR CTD; 57464; -.
DR MGI; MGI:2444363; Strip2.
DR VEuPathDB; HostDB:ENSMUSG00000039629; -.
DR eggNOG; KOG3680; Eukaryota.
DR GeneTree; ENSGT00400000022095; -.
DR InParanoid; Q8C9H6; -.
DR OMA; RHNNFLL; -.
DR PhylomeDB; Q8C9H6; -.
DR TreeFam; TF314205; -.
DR BioGRID-ORCS; 320609; 5 hits in 74 CRISPR screens.
DR PRO; PR:Q8C9H6; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q8C9H6; protein.
DR Bgee; ENSMUSG00000039629; Expressed in olfactory tubercle and 146 other tissues.
DR ExpressionAtlas; Q8C9H6; baseline and differential.
DR Genevisible; Q8C9H6; MM.
DR GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0016477; P:cell migration; ISS:UniProtKB.
DR GO; GO:0007010; P:cytoskeleton organization; ISS:UniProtKB.
DR GO; GO:0008360; P:regulation of cell shape; ISS:UniProtKB.
DR InterPro; IPR040185; Far11/STRP.
DR InterPro; IPR021819; Far11/STRP_C.
DR InterPro; IPR012486; Far11/STRP_N.
DR PANTHER; PTHR13239; PTHR13239; 1.
DR Pfam; PF11882; DUF3402; 2.
DR Pfam; PF07923; N1221; 1.
DR SMART; SM01293; DUF3402; 1.
DR SMART; SM01292; N1221; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Cytoplasm; Phosphoprotein; Reference proteome.
FT CHAIN 1..844
FT /note="Striatin-interacting proteins 2"
FT /id="PRO_0000187023"
FT REGION 1..58
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 331..355
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 370..422
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..28
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 38..56
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 328
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 339
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 364
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT VAR_SEQ 659..662
FT /note="EAGD -> GLSV (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_019001"
FT VAR_SEQ 663..844
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_019002"
FT VAR_SEQ 694..721
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:12693553"
FT /id="VSP_014870"
FT CONFLICT 47
FT /note="Q -> L (in Ref. 2; BAC65741)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 844 AA; 96294 MW; 78E4D64476A7B097 CRC64;
MDDPAAPGPA GSPANDNGNG NGNGNGNGNG GKGKPAVPKG RETFRNQRRE SEGSVDCPTL
EFEYGDSDGH AAELSELYSY TENLEFTTNR KCFEEDFRTQ VQDTKEWLEL EEDAQKTYVM
GLLDRLEVVS REKRLKVARA VLYLAQGTFG ECDSEVDVLH WSRYNCFLLY QMGTFSAFLE
LLHMEIDNSQ ASSSALRKPA VSIADSTELR VLLSVMYLMV ENIRLEREID PCGWRTARET
FRTELSFSTH NEEPFALLLF SMVTKFCSGL APHFPIKKVL LLLWKVVMFT LGGFEHLQAL
KIQKRAELGL PPLAEDSIQV VKSMRAASPP SYTLDLGESQ LAPPPSKLRG RRGSRRQLLT
KQDSLDIYNE RDLFKTEEPA TEEEEESAAD GERTLDGELD LLEQDPLVPP PPSQTPLSTD
RVAFPKGLPW APKVRQKDIE HFLEMSRNKF IGFTLGQDTD TLVGLPRPIH ESVKTLKQHK
YISIADIQIK NEEELEKCPL SLGEEVVPET PSEILYQGML YSLPQYMIAL LKILLAAAPT
SKAKTDSINI LADVLPEEMP VTVLQSMKLG IDVNRHKEII VKSISALLLL LLKHFKLNHI
YQFEYVSQHL VFANCIPLIL KFFNQNILSY ITAKNSISVL DYPCCTIQDL PELTTESLEA
GDNSQFCWRN LFSCINLLRL LNKLTKWKHS RTMMLVVFKS APILKRALKV KQAMLQLYVL
KLLKIQTKYL GRQWRKSNMK TMSAIYQKVR HRMNDDWAYG NDIDARPWDF QAEECTLRAN
IEAFNSRRYD KPQDSEFSPV DNCLQSVLGQ RLDLPEDFHY SYELWLEREV FSQPICWEEL
LQNH
