ID   STRP_STRS1              Reviewed;         440 AA.
AC   P10519;
DT   01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT   01-JUL-1989, sequence version 1.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Streptokinase G;
DE   Flags: Precursor;
GN   Name=skg;
OS   Streptococcus sp. (strain 19909).
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=69017;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2922269; DOI=10.1093/nar/17.3.1262;
RA   Walter F., Siegel M., Malke H.;
RT   "Nucleotide sequence of the streptokinase gene from a group-G
RT   Streptococcus.";
RL   Nucleic Acids Res. 17:1262-1262(1989).
CC   -!- FUNCTION: This protein is not a protease, but it activates plasminogen
CC       by complexing with it. As a potential virulence factor, it is thought
CC       to prevent the formation of effective fibrin barriers around the site
CC       of infection, thereby contributing to the invasiveness of the cells.
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DR   EMBL; X13400; CAA31766.1; -; Genomic_DNA.
DR   PIR; S02723; S02723.
DR   AlphaFoldDB; P10519; -.
DR   SMR; P10519; -.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0031639; P:plasminogen activation; IEA:InterPro.
DR   InterPro; IPR036120; SAK/SK_sf.
DR   InterPro; IPR008124; SK.
DR   PRINTS; PR01753; STREPKINASE.
DR   SUPFAM; SSF54328; SSF54328; 3.
PE   4: Predicted;
KW   Plasminogen activation; Signal; Virulence.
FT   SIGNAL          1..26
FT   CHAIN           27..440
FT                   /note="Streptokinase G"
FT                   /id="PRO_0000022430"
SQ   SEQUENCE   440 AA;  50199 MW;  5521F8825FE1B6EA CRC64;
     MKNYLSFGMF ALLFALTFGT VNSVQAIAGP EWLLDRPSVN NSQLVVSVAG TVEGTNQDIS
     LKFFEIDLTS RPAHGGKTEQ GLSPKSKLFA TDSGAMPHKL EKADLLKAIQ EQLIANVHSN
     DDYFEVIDFA SDATITDRNG KVYFADKDGS VTLPIQPVQE FLLKGHVRVR PYKEKPVQNQ
     AKSVDVEYTV QFTPLNPDDD FRPALKDTKL LKTLAIGDTI TSQELLAQAQ SILNKNHPGY
     TIYERDSSIV THDNDIFRTI LPMDQEFTYH VKNREQAYRI NKKSGLNEEI NNTDLISEKY
     YVLKKGEKPY DPFDRSHLKL FTIKYVDVNT NELLKSEQLL TASERNLDFR DLYDPRDKAK
     LLYNNLDAFG IMDYTLTGKV EDNHDDTNRI ITVYMGKRPE GENASYHLAY DKDRYTEEER
     EVYSYLRYTG TPIPDNPNDK