ID   STRQ_STRPY              Reviewed;         440 AA.
AC   P96471;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-MAY-1997, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Streptokinase;
DE   Flags: Precursor;
GN   Name=ska;
OS   Streptococcus pyogenes.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=1314;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=CIP 56.57;
RX   PubMed=8746458; DOI=10.3109/10425179509074696;
RA   Ball M.M., Puig J., Iborra F.;
RT   "Cloning and sequencing of the streptokinase gene from Streptococcus
RT   pyogenes (CIP 56.57).";
RL   DNA Seq. 6:33-36(1995).
CC   -!- FUNCTION: This protein is not a protease, but it activates plasminogen
CC       by complexing with it. As a potential virulence factor, it is thought
CC       to prevent the formation of effective fibrin barriers around the site
CC       of infection, thereby contributing to the invasiveness of the cells (By
CC       similarity). {ECO:0000250}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; Z48617; CAA88532.1; -; Genomic_DNA.
DR   RefSeq; WP_020837796.1; NZ_UHHF01000002.1.
DR   AlphaFoldDB; P96471; -.
DR   SMR; P96471; -.
DR   BindingDB; P96471; -.
DR   ChEMBL; CHEMBL2346485; -.
DR   GO; GO:0005576; C:extracellular region; IEA:InterPro.
DR   GO; GO:0031639; P:plasminogen activation; IEA:InterPro.
DR   InterPro; IPR036120; SAK/SK_sf.
DR   InterPro; IPR008124; SK.
DR   PRINTS; PR01753; STREPKINASE.
DR   SUPFAM; SSF54328; SSF54328; 3.
PE   3: Inferred from homology;
KW   Plasminogen activation; Signal; Virulence.
FT   SIGNAL          1..26
FT                   /evidence="ECO:0000250"
FT   CHAIN           27..440
FT                   /note="Streptokinase"
FT                   /id="PRO_0000022431"
FT   REGION          72..94
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   440 AA;  49910 MW;  5513BF418B434A07 CRC64;
     MKNYLSFGMF ALLFALTFGT VKPVQAIAGP EWLLGRPSVN NSQLVVSVAG TVEGTNQEIS
     LKFFEIDLTS RPAQGGKTEQ GLRPKSKPLA TDKGAMSHKL EKADLLKAIQ EQLIANVHSN
     DGYFEVIDFA SDATITDRNG KVYFADRDDS VTLPTQPVQE FLLSGHVRVR PYRPKAVHNS
     AERVNVNYEV SFVSETGNLD FTPSLKEQYH LTTLAVGDSL SSQELAAIAQ FILSKKHPDY
     IITKRDSSIV THDNDIFRTI LPMDQEFTYH IKDREQAYKA NSKTGIEEKT NNTDLISEKY
     YILKKGEKPY DPFDRSHLKL FTIKYVDVDT KALLKSEQLL TASERNLDFR DLYDPRDKAK
     LLYNNLDAFG IMGYTLTGKV EDNHDDTNRI ITVYMGKRPE GENASYHLAY DKDRYTEEER
     EVYSYLRDTG TPIPDNPKDK