ID   STS1_AJECG              Reviewed;         312 AA.
AC   C0NIT8;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-MAY-2009, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=Tethering factor for nuclear proteasome STS1;
GN   Name=STS1; ORFNames=HCBG_02345;
OS   Ajellomyces capsulatus (strain G186AR / H82 / ATCC MYA-2454 / RMSCC 2432)
OS   (Darling's disease fungus) (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma.
OX   NCBI_TaxID=447093;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=G186AR / H82 / ATCC MYA-2454 / RMSCC 2432;
RA   Champion M., Cuomo C.A., Ma L.-J., Henn M.R., Sil A., Goldman B.,
RA   Young S.K., Kodira C.D., Zeng Q., Koehrsen M., Alvarado L., Berlin A.,
RA   Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J.,
RA   Griggs A., Gujja S., Heiman D., Hepburn T., Howarth C., Jen D., Larson L.,
RA   Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.,
RA   Shenoy N., Sisk P., Stolte C., Sykes S., Walk T., White J., Yandava C.,
RA   Klein B., McEwen J.G., Puccia R., Goldman G.H., Felipe M.S., Nino-Vega G.,
RA   San-Blas G., Taylor J., Mendoza L., Galagan J.E., Nusbaum C., Birren B.W.;
RT   "The genome sequence of Ajellomyces capsulatus strain G186AR.";
RL   Submitted (FEB-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in ubiquitin-mediated protein degradation.
CC       Regulatory factor in the ubiquitin/proteasome pathway that controls the
CC       turnover of proteasome substrates. Targets proteasomes to the nucleus
CC       and facilitates the degradation of nuclear proteins (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Binds the proteasome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cut8/STS1 family. {ECO:0000305}.
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DR   EMBL; GG663365; EEH08808.1; -; Genomic_DNA.
DR   AlphaFoldDB; C0NIT8; -.
DR   SMR; C0NIT8; -.
DR   STRING; 447093.C0NIT8; -.
DR   PRIDE; C0NIT8; -.
DR   EnsemblFungi; EEH08808; EEH08808; HCBG_02345.
DR   VEuPathDB; FungiDB:HCBG_02345; -.
DR   HOGENOM; CLU_033658_0_0_1; -.
DR   InParanoid; C0NIT8; -.
DR   OrthoDB; 1349270at2759; -.
DR   Proteomes; UP000001631; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0071630; P:nuclear protein quality control by the ubiquitin-proteasome system; IEA:InterPro.
DR   GO; GO:0031144; P:proteasome localization; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.58.1590; -; 1.
DR   InterPro; IPR013868; Cut8/Sts1_fam.
DR   InterPro; IPR038422; Cut8/Sts1_sf.
DR   PANTHER; PTHR28032; PTHR28032; 1.
DR   Pfam; PF08559; Cut8; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..312
FT                   /note="Tethering factor for nuclear proteasome STS1"
FT                   /id="PRO_0000409387"
FT   REGION          1..82
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        34..48
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   312 AA;  34358 MW;  3D30CB6F8D7FF703 CRC64;
     MNSLLATPPV PPHFYEHCRL SPSRSMSSTN PSGNRKRKAE DDYLPSDHDT RMSASPSNSP
     AFPPRPLPAS RQIKRSRPNI SGRPLSLSRL LETLDTDALR SVLRSMCDRH PELATEVVHT
     APRPSVSSAL QVLNNYQSAL HSSIPLGGNS SSDYAYNRVR QHIVNLLDAL SDFTPHFLPP
     NESQTSTALS YLDGATEILH RLPRWDTPQN NLEKDAAYEE MAKAWILVIR EAGKRGGGIQ
     LQYGGWDEKL SKHNQTAGGK LQDAVDVLSS NLGWMGTNQD LSNNQGVDAS SIRQQLLSGT
     YGSGMPLKVG RW