ID   STS1_AJECN              Reviewed;         312 AA.
AC   A6R7I3;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   21-AUG-2007, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Tethering factor for nuclear proteasome STS1;
GN   Name=STS1; ORFNames=HCAG_05591;
OS   Ajellomyces capsulatus (strain NAm1 / WU24) (Darling's disease fungus)
OS   (Histoplasma capsulatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Ajellomycetaceae; Histoplasma;
OC   unclassified Histoplasma.
OX   NCBI_TaxID=2059318;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NAm1 / WU24;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- FUNCTION: Involved in ubiquitin-mediated protein degradation.
CC       Regulatory factor in the ubiquitin/proteasome pathway that controls the
CC       turnover of proteasome substrates. Targets proteasomes to the nucleus
CC       and facilitates the degradation of nuclear proteins (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Binds the proteasome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cut8/STS1 family. {ECO:0000305}.
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DR   EMBL; CH476659; EDN09092.1; -; Genomic_DNA.
DR   RefSeq; XP_001540124.1; XM_001540074.1.
DR   AlphaFoldDB; A6R7I3; -.
DR   SMR; A6R7I3; -.
DR   STRING; 339724.A6R7I3; -.
DR   EnsemblFungi; EDN09092; EDN09092; HCAG_05591.
DR   GeneID; 5446511; -.
DR   KEGG; aje:HCAG_05591; -.
DR   VEuPathDB; FungiDB:HCAG_05591; -.
DR   HOGENOM; CLU_033658_0_0_1; -.
DR   OMA; SSLGWMH; -.
DR   OrthoDB; 1349270at2759; -.
DR   Proteomes; UP000009297; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0071630; P:nuclear protein quality control by the ubiquitin-proteasome system; IEA:InterPro.
DR   GO; GO:0031144; P:proteasome localization; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.58.1590; -; 1.
DR   InterPro; IPR013868; Cut8/Sts1_fam.
DR   InterPro; IPR038422; Cut8/Sts1_sf.
DR   PANTHER; PTHR28032; PTHR28032; 1.
DR   Pfam; PF08559; Cut8; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..312
FT                   /note="Tethering factor for nuclear proteasome STS1"
FT                   /id="PRO_0000409389"
FT   REGION          1..84
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        34..48
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   312 AA;  34371 MW;  54186D5AEEC91376 CRC64;
     MNSLLATPPV PPHFYEHCRL SPSRSMSSTN PSGNRKRKAE DDYLPSDHDT RMSASPSNSP
     AFPPRPLPAS RQIKRPRPNI SGRPLSLSRL LETLDTDALR SVLRSMCDRH PELATEVVHT
     APRPSVSSAL QVLNNYQSAL HSSIPLGGNS SSDYAYNRVR QHIVNLLDAL SDFTPHFLPP
     NESQTSTALS YLDGATEILH RLPRWDTPQN NLEKDAAYEE MAKAWILVIR EAGKRGGGIQ
     LQYGGWDEKL SKHNQTAGGK LQDAVDVLSS NLGWMGTSQD LSNNQGVDTS SIRQQLLSGT
     YGSGMPLKVG RW