ID   STS1_ARTOC              Reviewed;         341 AA.
AC   C5FF22;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=Tethering factor for nuclear proteasome STS1;
GN   Name=STS1; ORFNames=MCYG_01204;
OS   Arthroderma otae (strain ATCC MYA-4605 / CBS 113480) (Microsporum canis).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Microsporum.
OX   NCBI_TaxID=554155;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4605 / CBS 113480;
RX   PubMed=22951933; DOI=10.1128/mbio.00259-12;
RA   Martinez D.A., Oliver B.G., Graeser Y., Goldberg J.M., Li W.,
RA   Martinez-Rossi N.M., Monod M., Shelest E., Barton R.C., Birch E.,
RA   Brakhage A.A., Chen Z., Gurr S.J., Heiman D., Heitman J., Kosti I.,
RA   Rossi A., Saif S., Samalova M., Saunders C.W., Shea T., Summerbell R.C.,
RA   Xu J., Young S., Zeng Q., Birren B.W., Cuomo C.A., White T.C.;
RT   "Comparative genome analysis of Trichophyton rubrum and related
RT   dermatophytes reveals candidate genes involved in infection.";
RL   MBio 3:E259-E259(2012).
CC   -!- FUNCTION: Involved in ubiquitin-mediated protein degradation.
CC       Regulatory factor in the ubiquitin/proteasome pathway that controls the
CC       turnover of proteasome substrates. Targets proteasomes to the nucleus
CC       and facilitates the degradation of nuclear proteins (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Binds the proteasome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cut8/STS1 family. {ECO:0000305}.
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DR   EMBL; DS995701; EEQ28316.1; -; Genomic_DNA.
DR   RefSeq; XP_002851100.1; XM_002851054.1.
DR   AlphaFoldDB; C5FF22; -.
DR   SMR; C5FF22; -.
DR   STRING; 63405.XP_002851100.1; -.
DR   PRIDE; C5FF22; -.
DR   EnsemblFungi; EEQ28316; EEQ28316; MCYG_01204.
DR   GeneID; 9228641; -.
DR   eggNOG; ENOG502RNK4; Eukaryota.
DR   HOGENOM; CLU_813723_0_0_1; -.
DR   OrthoDB; 1349270at2759; -.
DR   Proteomes; UP000002035; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0071630; P:nuclear protein quality control by the ubiquitin-proteasome system; IEA:InterPro.
DR   GO; GO:0031144; P:proteasome localization; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.58.1590; -; 1.
DR   InterPro; IPR013868; Cut8/Sts1_fam.
DR   InterPro; IPR038422; Cut8/Sts1_sf.
DR   PANTHER; PTHR28032; PTHR28032; 1.
DR   Pfam; PF08559; Cut8; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..341
FT                   /note="Tethering factor for nuclear proteasome STS1"
FT                   /id="PRO_0000409393"
FT   REGION          1..84
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        18..33
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   341 AA;  37938 MW;  DF8119B924F5C6D6 CRC64;
     MNSLIATPPV PPHFYETSCR SPSYSMSSTN TSVNRKRKAE DDCPPSGDTR MSASPSGSPA
     LHPRPLAPRH LKRPRPNVSG RPLSLPRLME TLDTDALRSV LRSLCDRHPE IASEVMHTAP
     RPSVSAALEV LSNYQSTLQS SFPLGGNPSS DYAYNRVRQH LTNLLEALND FTPHFLPPNE
     SQPSTSLSYL DGATDIIHRL PRWTTPQHNI EEYAATEAGT KNWQSTNETA GGKLQDALKR
     AQPEPWVDRW QTWATRATAL RETSRRYANS SCRAHTVLAY RSKSGHGNSI QYQSSKPHFL
     FSTFNPSIHP SITALLSTPH YTVQVDGFRA IFNETITIPI C