ID   STS1_ASHGO              Reviewed;         320 AA.
AC   Q74ZG4;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2010, sequence version 2.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Tethering factor for nuclear proteasome STS1;
GN   Name=STS1; OrderedLocusNames=AGR243W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Involved in ubiquitin-mediated protein degradation.
CC       Regulatory factor in the ubiquitin/proteasome pathway that controls the
CC       turnover of proteasome substrates. Targets proteasomes to the nucleus
CC       and facilitates the degradation of nuclear proteins (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Binds the proteasome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cut8/STS1 family. {ECO:0000305}.
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DR   EMBL; AE016820; AAS54733.2; -; Genomic_DNA.
DR   RefSeq; NP_986909.2; NM_211971.2.
DR   AlphaFoldDB; Q74ZG4; -.
DR   SMR; Q74ZG4; -.
DR   STRING; 33169.AAS54733; -.
DR   PRIDE; Q74ZG4; -.
DR   EnsemblFungi; AAS54733; AAS54733; AGOS_AGR243W.
DR   GeneID; 4623211; -.
DR   KEGG; ago:AGOS_AGR243W; -.
DR   eggNOG; ENOG502RNK4; Eukaryota.
DR   HOGENOM; CLU_054606_1_0_1; -.
DR   InParanoid; Q74ZG4; -.
DR   OMA; NICYEQV; -.
DR   Proteomes; UP000000591; Chromosome VII.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007059; P:chromosome segregation; IEA:EnsemblFungi.
DR   GO; GO:0071630; P:nuclear protein quality control by the ubiquitin-proteasome system; IEA:EnsemblFungi.
DR   GO; GO:0031144; P:proteasome localization; IEA:EnsemblFungi.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.58.1590; -; 1.
DR   InterPro; IPR013868; Cut8/Sts1_fam.
DR   InterPro; IPR038422; Cut8/Sts1_sf.
DR   PANTHER; PTHR28032; PTHR28032; 1.
DR   Pfam; PF08559; Cut8; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..320
FT                   /note="Tethering factor for nuclear proteasome STS1"
FT                   /id="PRO_0000409394"
SQ   SEQUENCE   320 AA;  35756 MW;  A50EA4C9A588D67D CRC64;
     MSQSVGFEWG FKAGGEGRPR AQGDGAGCAG ATAAANSQQG CGHLVHMSYK VGKPKMKRRL
     TNEEHGGARR AKRQPAQFNV IQGQPLPVHR KIEMMDKAAL QLTLLQLVAM HPEVQDSLSV
     LQPTSPDPAK YTELLEQKMQ AVYDHIPYSK SSDMLNDYAF VRMKAAILEF LNCLIDCLLD
     AIPPRTTNLL QSFKFLAYGT RLLAQMPHFE TESNNYYKNI CYEQVSEIWN TLIRHASSDI
     NFLSTKPSLL HYLHELKQFN EQTKGKFDIP LRLFYTIMDD YHTQTVPAAA AVASTSATVA
     EELNGNSKSM ETLGIWNNVA