STS1_ASPFU
ID STS1_ASPFU Reviewed; 312 AA.
AC Q4WNW3;
DT 31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 1.
DT 25-MAY-2022, entry version 76.
DE RecName: Full=Tethering factor for nuclear proteasome sts1;
GN Name=sts1; ORFNames=AFUA_4G07170;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- FUNCTION: Involved in ubiquitin-mediated protein degradation.
CC Regulatory factor in the ubiquitin/proteasome pathway that controls the
CC turnover of proteasome substrates. Targets proteasomes to the nucleus
CC and facilitates the degradation of nuclear proteins (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Binds the proteasome. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the cut8/STS1 family. {ECO:0000305}.
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DR EMBL; AAHF01000005; EAL90071.1; -; Genomic_DNA.
DR RefSeq; XP_752109.1; XM_747016.1.
DR AlphaFoldDB; Q4WNW3; -.
DR SMR; Q4WNW3; -.
DR STRING; 746128.CADAFUBP00006251; -.
DR EnsemblFungi; EAL90071; EAL90071; AFUA_4G07170.
DR GeneID; 3509576; -.
DR KEGG; afm:AFUA_4G07170; -.
DR VEuPathDB; FungiDB:Afu4g07170; -.
DR eggNOG; ENOG502RNK4; Eukaryota.
DR HOGENOM; CLU_033658_0_0_1; -.
DR InParanoid; Q4WNW3; -.
DR OMA; SSLGWMH; -.
DR OrthoDB; 1349270at2759; -.
DR Proteomes; UP000002530; Chromosome 4.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0071630; P:nuclear protein quality control by the ubiquitin-proteasome system; IEA:InterPro.
DR GO; GO:0031144; P:proteasome localization; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR Gene3D; 1.20.58.1590; -; 1.
DR InterPro; IPR013868; Cut8/Sts1_fam.
DR InterPro; IPR038422; Cut8/Sts1_sf.
DR PANTHER; PTHR28032; PTHR28032; 1.
DR Pfam; PF08559; Cut8; 1.
PE 3: Inferred from homology;
KW Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport.
FT CHAIN 1..312
FT /note="Tethering factor for nuclear proteasome sts1"
FT /id="PRO_0000409398"
FT REGION 15..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..48
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 49..63
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 312 AA; 34181 MW; 3C97A814349F0102 CRC64;
MNSLVATPVP PHFYEYSRLS SPHPMSTPTH TPINRKRKAD DDGNDHDGRM SASPTNSPAF
TPRSLPAPRS FKRSRPNVSG RPLSLPRLLE TLDTDALRGI LRSMCERHPA LADEVIHTSP
RPSVSSALQV LRNYQSTLQN SFPLGGNPES DYAYNRVRQP LGNLLDALSD FTPHFLPPHE
TQASVSLSYL DGATDIIHAL PRWHSPQNNI ERDSAYDEIC KAWILVIREA AKRGGGIQLQ
YGGWDQKLAK HNQNAGGRLQ AAVNELGNSL GWMHGPDSQG YGSSTGGDLV SVREQLLSGT
YGLGTPVKVG PW