ID   STS1_CANGA              Reviewed;         280 AA.
AC   Q6FKQ4;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Tethering factor for nuclear proteasome STS1;
GN   Name=STS1; OrderedLocusNames=CAGL0L09625g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in ubiquitin-mediated protein degradation.
CC       Regulatory factor in the ubiquitin/proteasome pathway that controls the
CC       turnover of proteasome substrates. Targets proteasomes to the nucleus
CC       and facilitates the degradation of nuclear proteins (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Binds the proteasome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cut8/STS1 family. {ECO:0000305}.
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DR   EMBL; CR380958; CAG62160.1; -; Genomic_DNA.
DR   RefSeq; XP_449190.1; XM_449190.1.
DR   AlphaFoldDB; Q6FKQ4; -.
DR   SMR; Q6FKQ4; -.
DR   STRING; 5478.XP_449190.1; -.
DR   EnsemblFungi; CAG62160; CAG62160; CAGL0L09625g.
DR   GeneID; 2891073; -.
DR   KEGG; cgr:CAGL0L09625g; -.
DR   CGD; CAL0135166; CAGL0L09625g.
DR   VEuPathDB; FungiDB:CAGL0L09625g; -.
DR   eggNOG; ENOG502RNK4; Eukaryota.
DR   HOGENOM; CLU_054606_2_0_1; -.
DR   InParanoid; Q6FKQ4; -.
DR   OMA; SSLGWMH; -.
DR   Proteomes; UP000002428; Chromosome L.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0007059; P:chromosome segregation; IEA:EnsemblFungi.
DR   GO; GO:0071630; P:nuclear protein quality control by the ubiquitin-proteasome system; IEA:EnsemblFungi.
DR   GO; GO:0031144; P:proteasome localization; IEA:EnsemblFungi.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.58.1590; -; 1.
DR   InterPro; IPR013868; Cut8/Sts1_fam.
DR   InterPro; IPR038422; Cut8/Sts1_sf.
DR   PANTHER; PTHR28032; PTHR28032; 1.
DR   Pfam; PF08559; Cut8; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..280
FT                   /note="Tethering factor for nuclear proteasome STS1"
FT                   /id="PRO_0000409404"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        8..27
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   280 AA;  32351 MW;  179977F4A42E4A09 CRC64;
     MSGQMFWGKK EDGKRKRSFQ ESYETPKVQK CVRKRRPALN VQGQPLPPQR SLEMMSKDQL
     MSVLMEVMRQ HPEVGSTFQA KVSSYQFASE KYQQLLKGKV EQLYSNIPYN RSYDNTNLDD
     YAFVRMKPYI TELLNCLVDC ALDNLPPRKS DLHESLKFLE SCTQLVLDLP RFESGSNNYY
     YDKCLEQISH LWCSLIEQIS KDIHMVMNTN MEEWITKLNA YNERSNGLLT SAVTLFKSLA
     SDGDLLGDQQ NEMESPAYVA GPGLLLESNP SYLMHNKYSM