ID   STS1_COCP7              Reviewed;         314 AA.
AC   C5P8M7;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   01-SEP-2009, sequence version 1.
DT   25-MAY-2022, entry version 46.
DE   RecName: Full=Tethering factor for nuclear proteasome STS1;
GN   Name=STS1; ORFNames=CPC735_002580;
OS   Coccidioides posadasii (strain C735) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=222929;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C735;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
CC   -!- FUNCTION: Involved in ubiquitin-mediated protein degradation.
CC       Regulatory factor in the ubiquitin/proteasome pathway that controls the
CC       turnover of proteasome substrates. Targets proteasomes to the nucleus
CC       and facilitates the degradation of nuclear proteins (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Binds the proteasome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cut8/STS1 family. {ECO:0000305}.
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DR   EMBL; ACFW01000030; EER26089.1; -; Genomic_DNA.
DR   RefSeq; XP_003068234.1; XM_003068188.1.
DR   AlphaFoldDB; C5P8M7; -.
DR   SMR; C5P8M7; -.
DR   EnsemblFungi; EER26089; EER26089; CPC735_002580.
DR   GeneID; 9693717; -.
DR   KEGG; cpw:CPC735_002580; -.
DR   VEuPathDB; FungiDB:CPC735_002580; -.
DR   HOGENOM; CLU_033658_0_0_1; -.
DR   Proteomes; UP000009084; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0071630; P:nuclear protein quality control by the ubiquitin-proteasome system; IEA:InterPro.
DR   GO; GO:0031144; P:proteasome localization; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.58.1590; -; 1.
DR   InterPro; IPR013868; Cut8/Sts1_fam.
DR   InterPro; IPR038422; Cut8/Sts1_sf.
DR   PANTHER; PTHR28032; PTHR28032; 1.
DR   Pfam; PF08559; Cut8; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Protein transport; Transport.
FT   CHAIN           1..314
FT                   /note="Tethering factor for nuclear proteasome STS1"
FT                   /id="PRO_0000409407"
FT   REGION          24..85
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        35..49
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        50..65
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   314 AA;  34490 MW;  AED1F5736E084A26 CRC64;
     MNSLVATPPI PPHFYEHNRF NTTSRFVSPM NPAGSRKRKA EDDNGSSDHD TRMSASPTSS
     PALPTKPLAA RQIKRPRPNL SGRPLSLGRL FETLDSDALR SVLRSLCDRH PELGQEVVDT
     APRPNITSAL QVLSNYQSTL QSSFPLGGNP SSDYAYNRVR PHVMNLLDAL NDFTPHFLPP
     NETHPSTSLN YLDGVTEIIH QLPRWDTPHY NLEKEAAYEE IAKAWALVIR EASKRGGGIQ
     LQYGEWDQKL AKHNQTSGGK LQDAVHELSA SLGWMAGNPS HPGPGCPQAD TASIRQQLLS
     GTYGAGLPLK VGPW