ID   STS1_KOMPG              Reviewed;         291 AA.
AC   C4R591;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   07-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 54.
DE   RecName: Full=Tethering factor for nuclear proteasome STS1;
GN   Name=STS1; OrderedLocusNames=PAS_chr3_0678;
OS   Komagataella phaffii (strain GS115 / ATCC 20864) (Yeast) (Pichia pastoris).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Phaffomycetaceae; Komagataella.
OX   NCBI_TaxID=644223;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=GS115 / ATCC 20864;
RX   PubMed=19465926; DOI=10.1038/nbt.1544;
RA   De Schutter K., Lin Y.-C., Tiels P., Van Hecke A., Glinka S.,
RA   Weber-Lehmann J., Rouze P., Van de Peer Y., Callewaert N.;
RT   "Genome sequence of the recombinant protein production host Pichia
RT   pastoris.";
RL   Nat. Biotechnol. 27:561-566(2009).
CC   -!- FUNCTION: Involved in ubiquitin-mediated protein degradation.
CC       Regulatory factor in the ubiquitin/proteasome pathway that controls the
CC       turnover of proteasome substrates. Targets proteasomes to the nucleus
CC       and facilitates the degradation of nuclear proteins (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Binds the proteasome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cut8/STS1 family. {ECO:0000305}.
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DR   EMBL; FN392321; CAY70727.1; -; Genomic_DNA.
DR   RefSeq; XP_002492906.1; XM_002492861.1.
DR   AlphaFoldDB; C4R591; -.
DR   SMR; C4R591; -.
DR   STRING; 644223.C4R591; -.
DR   PRIDE; C4R591; -.
DR   EnsemblFungi; CAY70727; CAY70727; PAS_chr3_0678.
DR   GeneID; 8200378; -.
DR   KEGG; ppa:PAS_chr3_0678; -.
DR   eggNOG; ENOG502RNK4; Eukaryota.
DR   HOGENOM; CLU_054606_0_0_1; -.
DR   InParanoid; C4R591; -.
DR   OMA; NICYEQV; -.
DR   Proteomes; UP000000314; Chromosome 3.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0071630; P:nuclear protein quality control by the ubiquitin-proteasome system; IEA:InterPro.
DR   GO; GO:0031144; P:proteasome localization; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.58.1590; -; 1.
DR   InterPro; IPR013868; Cut8/Sts1_fam.
DR   InterPro; IPR038422; Cut8/Sts1_sf.
DR   PANTHER; PTHR28032; PTHR28032; 1.
DR   Pfam; PF08559; Cut8; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..291
FT                   /note="Tethering factor for nuclear proteasome STS1"
FT                   /id="PRO_0000409428"
FT   REGION          37..56
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        40..56
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   291 AA;  33421 MW;  63C00CE2E0C4C1E6 CRC64;
     MSSLQTSFPW GFKKAVISKP TKNKRKIQED IDTLGDAKSR TKFHPNNSNS TSRKHRTHAI
     MGTKLPLNTL IETLDHESLQ KLVKSLVEQR PDVQEALYNA APTVTVQVCI DKLTDKVENI
     KCNLPYKVDT ECDYTYLRVK ALVHEFFQAL SDYMLNFLPP QEYDVSKSIE FLNGFLLKVL
     LKMPMFSHME FKYYYKLTLD KLNTVYVNLI ADFIQQKPTN ILLLKDSDLA EKLLEINKHY
     EDYFEQVSQL LSQDEGSDIP ERLQGLSNLL NFSSENNPLN GGVVSSVKGS W