ID   STS1_LODEL              Reviewed;         437 AA.
AC   A5DSS9;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 50.
DE   RecName: Full=Tethering factor for nuclear proteasome STS1;
GN   Name=STS1; ORFNames=LELG_00415;
OS   Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC
OS   1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade;
OC   Lodderomyces.
OX   NCBI_TaxID=379508;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11503 / BCRC 21390 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL
RC   YB-4239;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Involved in ubiquitin-mediated protein degradation.
CC       Regulatory factor in the ubiquitin/proteasome pathway that controls the
CC       turnover of proteasome substrates. Targets proteasomes to the nucleus
CC       and facilitates the degradation of nuclear proteins (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Binds the proteasome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cut8/STS1 family. {ECO:0000305}.
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DR   EMBL; CH981524; EDK42237.1; -; Genomic_DNA.
DR   RefSeq; XP_001527895.1; XM_001527845.1.
DR   AlphaFoldDB; A5DSS9; -.
DR   SMR; A5DSS9; -.
DR   STRING; 379508.A5DSS9; -.
DR   EnsemblFungi; EDK42237; EDK42237; LELG_00415.
DR   GeneID; 5234941; -.
DR   KEGG; lel:LELG_00415; -.
DR   VEuPathDB; FungiDB:LELG_00415; -.
DR   eggNOG; ENOG502RNK4; Eukaryota.
DR   HOGENOM; CLU_627095_0_0_1; -.
DR   InParanoid; A5DSS9; -.
DR   OMA; NNIPPNF; -.
DR   OrthoDB; 1349270at2759; -.
DR   Proteomes; UP000001996; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0071630; P:nuclear protein quality control by the ubiquitin-proteasome system; IEA:InterPro.
DR   GO; GO:0031144; P:proteasome localization; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.58.1590; -; 1.
DR   InterPro; IPR013868; Cut8/Sts1_fam.
DR   InterPro; IPR038422; Cut8/Sts1_sf.
DR   PANTHER; PTHR28032; PTHR28032; 1.
DR   Pfam; PF08559; Cut8; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..437
FT                   /note="Tethering factor for nuclear proteasome STS1"
FT                   /id="PRO_0000409414"
FT   REGION          1..110
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          385..416
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        18..76
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        77..97
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   437 AA;  49280 MW;  D1C673CB4BB7D2CC CRC64;
     MMSASFHWKH RSNEQGKNPL DKSAMPSSTL HYMSTNNSTN NGTGTSTNTS GSSSHYTIAP
     RSFSEMVPSQ QQQQQNKKRK RYSDDDSETH NETHSENNND TSQEQFKPHN HRDQTASGLL
     HLQQQQLQQQ HSLLLLQQLH YFHGSSKTKR TKIPKIIGQP LPTSRLIESL DKTHLEKLLH
     SLIDIHPELN KTIQKITPKP SLENLLLILQ DKHAQLIDHL PYKCSETSDY SYLRIKPYLQ
     EFLSCLEDYV LYYLPSNNYS ETKHKLIQSL KFIDEATSTI HKLPNFTNSE YQYMRNLTYE
     QLINCWLILV NQETNCDTGN GLDYTEFHKI VEELDLLESL KQHGVQSGQE GFSKVIEAVQ
     NKLGQNQILL SRQFGIDYGN DMTVSSSNGN RSGTGAGFGG GGGGASRSGS GSGTSSNALS
     DMITVDYSLY SLSNRSV