ID   STS1_OGAPD              Reviewed;         309 AA.
AC   E7RAM2; W1Q7X3;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-APR-2014, sequence version 2.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=Tethering factor for nuclear proteasome STS1;
GN   Name=STS1; ORFNames=HPODL_03130;
OS   Ogataea parapolymorpha (strain ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL
OS   Y-7560 / DL-1) (Yeast) (Hansenula polymorpha).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Pichiaceae; Ogataea.
OX   NCBI_TaxID=871575;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 26012 / BCRC 20466 / JCM 22074 / NRRL Y-7560 / DL-1;
RX   PubMed=24279325; DOI=10.1186/1471-2164-14-837;
RA   Ravin N.V., Eldarov M.A., Kadnikov V.V., Beletsky A.V., Schneider J.,
RA   Mardanova E.S., Smekalova E.M., Zvereva M.I., Dontsova O.A., Mardanov A.V.,
RA   Skryabin K.G.;
RT   "Genome sequence and analysis of methylotrophic yeast Hansenula polymorpha
RT   DL1.";
RL   BMC Genomics 14:837-837(2013).
CC   -!- FUNCTION: Involved in ubiquitin-mediated protein degradation.
CC       Regulatory factor in the ubiquitin/proteasome pathway that controls the
CC       turnover of proteasome substrates. Targets proteasomes to the nucleus
CC       and facilitates the degradation of nuclear proteins (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Binds the proteasome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cut8/STS1 family. {ECO:0000305}.
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DR   EMBL; AEOI02000010; ESW96508.1; -; Genomic_DNA.
DR   RefSeq; XP_013932938.1; XM_014077463.1.
DR   AlphaFoldDB; E7RAM2; -.
DR   SMR; E7RAM2; -.
DR   STRING; 1005962.E7RAM2; -.
DR   PRIDE; E7RAM2; -.
DR   EnsemblFungi; ESW96508; ESW96508; HPODL_03130.
DR   GeneID; 25772575; -.
DR   eggNOG; ENOG502RNK4; Eukaryota.
DR   HOGENOM; CLU_054606_0_0_1; -.
DR   OMA; NICYEQV; -.
DR   OrthoDB; 1349270at2759; -.
DR   Proteomes; UP000008673; Chromosome VII.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0071630; P:nuclear protein quality control by the ubiquitin-proteasome system; IEA:InterPro.
DR   GO; GO:0031144; P:proteasome localization; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.58.1590; -; 1.
DR   InterPro; IPR013868; Cut8/Sts1_fam.
DR   InterPro; IPR038422; Cut8/Sts1_sf.
DR   PANTHER; PTHR28032; PTHR28032; 1.
DR   Pfam; PF08559; Cut8; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..309
FT                   /note="Tethering factor for nuclear proteasome STS1"
FT                   /id="PRO_0000409426"
FT   REGION          20..45
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        28..45
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   309 AA;  35668 MW;  F53FC404EADE560A CRC64;
     MTLTNQMDFQ NHFLAKDLHR ITKPKKVGKR RHTDESNDED ASKPRFMPKT LSKLAQHKKQ
     RQPQVMGQKL SVSRIIETLD QESLQNLISN LVSEHPEVAP TLLKISPQVT IEDSLMVLEQ
     KLERILQNMP YRVDASSDYS FLRVKPHVED FFQTLSDYTL NFLPPIESDL TVPLMFLMKF
     LAKCFPRLPK FHAVEYRYYH SLTVDKFNTI LDDILVQFLS EKKHNIILAI NQDWLTDFRK
     ISELNDNNFS SVYERLKQEI DQYENPDAAS GQPSTNNAGR LTGLANLLNF SSDNSPLHGN
     TVGNVFDTI