ID   STS1_PENRW              Reviewed;         311 AA.
AC   B6HUK8;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 1.
DT   03-AUG-2022, entry version 58.
DE   RecName: Full=Tethering factor for nuclear proteasome sts1;
GN   Name=sts1; ORFNames=Pc22g18360;
OS   Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin
OS   54-1255) (Penicillium chrysogenum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC   Penicillium chrysogenum species complex.
OX   NCBI_TaxID=500485;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255;
RX   PubMed=18820685; DOI=10.1038/nbt.1498;
RA   van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA   Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA   Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA   Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A., van der Klei I.J.,
RA   van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R.,
RA   Bovenberg R.A.L.;
RT   "Genome sequencing and analysis of the filamentous fungus Penicillium
RT   chrysogenum.";
RL   Nat. Biotechnol. 26:1161-1168(2008).
CC   -!- FUNCTION: Involved in ubiquitin-mediated protein degradation.
CC       Regulatory factor in the ubiquitin/proteasome pathway that controls the
CC       turnover of proteasome substrates. Targets proteasomes to the nucleus
CC       and facilitates the degradation of nuclear proteins (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Binds the proteasome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cut8/STS1 family. {ECO:0000305}.
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DR   EMBL; AM920437; CAP99124.1; -; Genomic_DNA.
DR   RefSeq; XP_002565741.1; XM_002565695.1.
DR   AlphaFoldDB; B6HUK8; -.
DR   SMR; B6HUK8; -.
DR   STRING; 1108849.XP_002565741.1; -.
DR   EnsemblFungi; CAP99124; CAP99124; PCH_Pc22g18360.
DR   GeneID; 8313496; -.
DR   KEGG; pcs:Pc22g18360; -.
DR   VEuPathDB; FungiDB:PCH_Pc22g18360; -.
DR   eggNOG; ENOG502RNK4; Eukaryota.
DR   HOGENOM; CLU_033658_0_0_1; -.
DR   OMA; SSLGWMH; -.
DR   OrthoDB; 1349270at2759; -.
DR   BioCyc; PCHR:PC22G18360-MON; -.
DR   Proteomes; UP000000724; Contig Pc00c22.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0071630; P:nuclear protein quality control by the ubiquitin-proteasome system; IEA:InterPro.
DR   GO; GO:0031144; P:proteasome localization; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.58.1590; -; 1.
DR   InterPro; IPR013868; Cut8/Sts1_fam.
DR   InterPro; IPR038422; Cut8/Sts1_sf.
DR   PANTHER; PTHR28032; PTHR28032; 1.
DR   Pfam; PF08559; Cut8; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..311
FT                   /note="Tethering factor for nuclear proteasome sts1"
FT                   /id="PRO_0000409423"
FT   REGION          1..83
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        20..34
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        35..49
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        50..64
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   311 AA;  34341 MW;  7BCF6C4AD48481BC CRC64;
     MNSLVATPPV PPHFYENSRF SPSRMMSTPS SSYSSRKRKA DDDNDHDGRM SASPTNSPAF
     TPRQLPHSYR NIKRSRPNVS GRPLSLPRLL ETLDTDALRT VVRTMCERHP QLADEVVHTS
     PRPNVSSTLQ VLRNYQAALQ SSFPLGGNTE SDYAYNRVRQ PLTNLLDALS DFTPNFLPPN
     ESQASTSLSY LDGATDIIHA LPRWSTPQNN IERDSAYDEM CKAWILVIRE AAKRGGGIQL
     QYGGWDQKLA KHNQTSGGKL QGAVNELGFS LGWMNGPDTP SHGANSEMGS IRDQLFSGTY
     GLGTPVKVGP W