ID   STS1_TALMQ              Reviewed;         312 AA.
AC   B6Q1K5;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 1.
DT   25-MAY-2022, entry version 48.
DE   RecName: Full=Tethering factor for nuclear proteasome sts1;
GN   Name=sts1; ORFNames=PMAA_027120;
OS   Talaromyces marneffei (strain ATCC 18224 / CBS 334.59 / QM 7333)
OS   (Penicillium marneffei).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC   Talaromyces sect. Talaromyces.
OX   NCBI_TaxID=441960;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 18224 / CBS 334.59 / QM 7333;
RX   PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA   Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT   "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT   (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT   (ATCC10500).";
RL   Genome Announc. 3:E0155914-E0155914(2015).
CC   -!- FUNCTION: Involved in ubiquitin-mediated protein degradation.
CC       Regulatory factor in the ubiquitin/proteasome pathway that controls the
CC       turnover of proteasome substrates. Targets proteasomes to the nucleus
CC       and facilitates the degradation of nuclear proteins (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Binds the proteasome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cut8/STS1 family. {ECO:0000305}.
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DR   EMBL; DS995899; EEA27871.1; -; Genomic_DNA.
DR   RefSeq; XP_002144386.1; XM_002144350.1.
DR   AlphaFoldDB; B6Q1K5; -.
DR   SMR; B6Q1K5; -.
DR   STRING; 441960.B6Q1K5; -.
DR   EnsemblFungi; EEA27871; EEA27871; PMAA_027120.
DR   GeneID; 7022165; -.
DR   KEGG; tmf:PMAA_027120; -.
DR   VEuPathDB; FungiDB:PMAA_027120; -.
DR   HOGENOM; CLU_033658_0_0_1; -.
DR   OrthoDB; 1349270at2759; -.
DR   PhylomeDB; B6Q1K5; -.
DR   Proteomes; UP000001294; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0071630; P:nuclear protein quality control by the ubiquitin-proteasome system; IEA:InterPro.
DR   GO; GO:0031144; P:proteasome localization; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.58.1590; -; 1.
DR   InterPro; IPR013868; Cut8/Sts1_fam.
DR   InterPro; IPR038422; Cut8/Sts1_sf.
DR   PANTHER; PTHR28032; PTHR28032; 1.
DR   Pfam; PF08559; Cut8; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..312
FT                   /note="Tethering factor for nuclear proteasome sts1"
FT                   /id="PRO_0000409424"
FT   REGION          1..83
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        20..34
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   312 AA;  34286 MW;  0BA4617FC233C4C6 CRC64;
     MNSLVATPPV PPHFYEHSRF SPSRSMSTPV QQNSNRKRKA EDDGNDVDVR MSASPTNSPA
     FTPRPLPNRQ MKRSRPNVSG RPLSLPRLLE TLDTEALRSV LQAVCQRHPE LGDEVVHTAP
     RPSVASTLQV LRNYQSTLQT SIPLGSGEYL SDYAYNRVKQ HLFSLLEALS DFTPHFLPPN
     ESQTSVSLTY LDGATDIIHG LPKWQTPRHN IGRDSAYEEI GKAWVLVIRE AAKRGGGIQL
     QYGGWDQKLA KHNETSGGKL QDAVNELRNS LGWMGSSALP GAGASGGDQI SIREQLLSGT
     YGMGMPLKVG PW