ID   STS1_TALSN              Reviewed;         315 AA.
AC   B8LTU5;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   03-MAR-2009, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=Tethering factor for nuclear proteasome sts1;
GN   Name=sts1; ORFNames=TSTA_071710;
OS   Talaromyces stipitatus (strain ATCC 10500 / CBS 375.48 / QM 6759 / NRRL
OS   1006) (Penicillium stipitatum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Trichocomaceae; Talaromyces;
OC   Talaromyces sect. Talaromyces.
OX   NCBI_TaxID=441959;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10500 / CBS 375.48 / QM 6759 / NRRL 1006;
RX   PubMed=25676766; DOI=10.1128/genomea.01559-14;
RA   Nierman W.C., Fedorova-Abrams N.D., Andrianopoulos A.;
RT   "Genome sequence of the AIDS-associated pathogen Penicillium marneffei
RT   (ATCC18224) and its near taxonomic relative Talaromyces stipitatus
RT   (ATCC10500).";
RL   Genome Announc. 3:E0155914-E0155914(2015).
CC   -!- FUNCTION: Involved in ubiquitin-mediated protein degradation.
CC       Regulatory factor in the ubiquitin/proteasome pathway that controls the
CC       turnover of proteasome substrates. Targets proteasomes to the nucleus
CC       and facilitates the degradation of nuclear proteins (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Binds the proteasome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cut8/STS1 family. {ECO:0000305}.
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DR   EMBL; EQ962652; EED23775.1; -; Genomic_DNA.
DR   RefSeq; XP_002341162.1; XM_002341121.1.
DR   AlphaFoldDB; B8LTU5; -.
DR   SMR; B8LTU5; -.
DR   STRING; 441959.B8LTU5; -.
DR   EnsemblFungi; EED23775; EED23775; TSTA_071710.
DR   GeneID; 8100238; -.
DR   VEuPathDB; FungiDB:TSTA_071710; -.
DR   eggNOG; ENOG502RNK4; Eukaryota.
DR   HOGENOM; CLU_033658_0_0_1; -.
DR   InParanoid; B8LTU5; -.
DR   OMA; SSLGWMH; -.
DR   OrthoDB; 1349270at2759; -.
DR   PhylomeDB; B8LTU5; -.
DR   Proteomes; UP000001745; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0071630; P:nuclear protein quality control by the ubiquitin-proteasome system; IEA:InterPro.
DR   GO; GO:0031144; P:proteasome localization; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.58.1590; -; 1.
DR   InterPro; IPR013868; Cut8/Sts1_fam.
DR   InterPro; IPR038422; Cut8/Sts1_sf.
DR   PANTHER; PTHR28032; PTHR28032; 1.
DR   Pfam; PF08559; Cut8; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..315
FT                   /note="Tethering factor for nuclear proteasome sts1"
FT                   /id="PRO_0000409434"
FT   REGION          1..83
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        20..34
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   315 AA;  34608 MW;  FCFD69610F714835 CRC64;
     MNSLVATPPV PPHFYEHSRF SPSRSMSTPA QQSSNRKRKA EDDGNDVDIR MSASPTNSPA
     FTPRPLPNRQ MKRSRPNVSG RPLSLPRLLE TLDTDALRSV LQAVCQRHPE LGDEVVHTAP
     RPSVSSTLQV LRNYQSTLQT SIPLGSGEYL SDYAYNRVKQ HLFNLLDALS DFTPHFLPPN
     ESQTSVSLTY LDGATDIIHS LPKWQTPRHN IGRDSAYEEI CKAWVLVIRE AAKRGGGIQL
     QYGGWDQKLA KHNETSGGKL QDAINELQNS LGWMGSSALP GVGAAGTQGG DQTSIREQLL
     SGTYGMGMPL KVGPW