ID   STS1_YARLI              Reviewed;         292 AA.
AC   Q6CH63;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Tethering factor for nuclear proteasome STS1;
GN   Name=STS1; OrderedLocusNames=YALI0A12023g;
OS   Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Dipodascaceae; Yarrowia.
OX   NCBI_TaxID=284591;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CLIB 122 / E 150;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in ubiquitin-mediated protein degradation.
CC       Regulatory factor in the ubiquitin/proteasome pathway that controls the
CC       turnover of proteasome substrates. Targets proteasomes to the nucleus
CC       and facilitates the degradation of nuclear proteins (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Binds the proteasome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cut8/STS1 family. {ECO:0000305}.
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DR   EMBL; CR382127; CAG83928.1; -; Genomic_DNA.
DR   RefSeq; XP_499999.1; XM_499999.1.
DR   AlphaFoldDB; Q6CH63; -.
DR   SMR; Q6CH63; -.
DR   STRING; 4952.CAG83928; -.
DR   EnsemblFungi; CAG83928; CAG83928; YALI0_A12023g.
DR   GeneID; 2906519; -.
DR   KEGG; yli:YALI0A12023g; -.
DR   VEuPathDB; FungiDB:YALI0_A12023g; -.
DR   HOGENOM; CLU_953789_0_0_1; -.
DR   InParanoid; Q6CH63; -.
DR   OMA; SSLGWMH; -.
DR   Proteomes; UP000001300; Chromosome A.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0071630; P:nuclear protein quality control by the ubiquitin-proteasome system; IEA:InterPro.
DR   GO; GO:0031144; P:proteasome localization; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.58.1590; -; 1.
DR   InterPro; IPR013868; Cut8/Sts1_fam.
DR   InterPro; IPR038422; Cut8/Sts1_sf.
DR   PANTHER; PTHR28032; PTHR28032; 1.
DR   Pfam; PF08559; Cut8; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..292
FT                   /note="Tethering factor for nuclear proteasome STS1"
FT                   /id="PRO_0000409435"
FT   REGION          24..68
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        37..56
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   292 AA;  32841 MW;  992C4184D3B92151 CRC64;
     MMGSVVPLSS PAWDLNLSAG QNLLGHGSPT PSHSRKRRLS VTPEAGDSHM EHESPSKPRQ
     QSPFVHKRAR VTRQLQSRPL PMSRLLSSLD QKTLVSLLEG ICAQDDRVAR QVMEVTPKPT
     VSSAMDVLSR ALDQAFALFP YKGDHQNDYA FFRVRPALEE FLAELSDYLS HFLPPNETQV
     SNSFAFLDQA TSLVHRMPQW SSPANNRLKE ETYEHIDVAW TLVCEEAAKR QRGSLAMSGV
     GNWLIRLEKH NELSGDRLKT SLHLLRDMLD DQGYRPPNPF ASFNGAQQLF TV