ID   STS1_YEAS8              Reviewed;         319 AA.
AC   C8ZAR0;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   03-NOV-2009, sequence version 1.
DT   25-MAY-2022, entry version 41.
DE   RecName: Full=Tethering factor for nuclear proteasome STS1;
DE   AltName: Full=Dumbbell former protein 8;
DE   AltName: Full=SEC23 suppressor 1;
GN   Name=STS1; Synonyms=DBF8, SSM5; ORFNames=EC1118_1I12_2168g;
OS   Saccharomyces cerevisiae (strain Lalvin EC1118 / Prise de mousse) (Baker's
OS   yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=643680;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Lalvin EC1118 / Prise de mousse;
RX   PubMed=19805302; DOI=10.1073/pnas.0904673106;
RA   Novo M., Bigey F., Beyne E., Galeote V., Gavory F., Mallet S., Cambon B.,
RA   Legras J.-L., Wincker P., Casaregola S., Dequin S.;
RT   "Eukaryote-to-eukaryote gene transfer events revealed by the genome
RT   sequence of the wine yeast Saccharomyces cerevisiae EC1118.";
RL   Proc. Natl. Acad. Sci. U.S.A. 106:16333-16338(2009).
CC   -!- FUNCTION: Involved in ubiquitin-mediated protein degradation.
CC       Regulatory factor in the ubiquitin/proteasome pathway that controls the
CC       turnover of proteasome substrates. Targets proteasomes to the nucleus
CC       and facilitates the degradation of nuclear proteins (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Binds the proteasome. Interacts with karyopherin SRP1 and
CC       Proteasome subunit RPN11. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cut8/STS1 family. {ECO:0000305}.
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DR   EMBL; FN393074; CAY80523.1; -; Genomic_DNA.
DR   AlphaFoldDB; C8ZAR0; -.
DR   SMR; C8ZAR0; -.
DR   EnsemblFungi; CAY80523; CAY80523; EC1118_1I12_2168g.
DR   HOGENOM; CLU_054606_1_0_1; -.
DR   Proteomes; UP000000286; Chromosome IX, Scaffold EC1118_1I12.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0071630; P:nuclear protein quality control by the ubiquitin-proteasome system; IEA:InterPro.
DR   GO; GO:0031144; P:proteasome localization; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.58.1590; -; 1.
DR   InterPro; IPR013868; Cut8/Sts1_fam.
DR   InterPro; IPR038422; Cut8/Sts1_sf.
DR   PANTHER; PTHR28032; PTHR28032; 1.
DR   Pfam; PF08559; Cut8; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Protein transport; Transport.
FT   CHAIN           1..319
FT                   /note="Tethering factor for nuclear proteasome STS1"
FT                   /id="PRO_0000409439"
FT   REGION          33..76
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        37..54
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   319 AA;  36485 MW;  4C5608D50B6AD829 CRC64;
     MMGFEWGFKP SSKITQSTVS SQGTGNVMIP TAGVKQKRRY ANEEQEEEEL PRNKNVMKYG
     GVSKRRPQPG SLIRGQPLPL QRGMELMNKN QLQQLLVDLM TKHPEIQQSV HTRVIGLDFS
     IQKCLDMLKQ KSEAVYQSIP YNRSYESNKL DDYAFVRMKP QILEFLNCLV DFILDNIPPR
     LENLHASLKF LDICTELVIK LPRFELASNN YYYDKCIEQL SHVWCTLIEH VARDRIILLA
     DNSSVWKSHM TRLQVYNEHS NGLLERPLQL FKSLDMGSPS AASSSTLSLQ ESIIYHHDTM
     TANENNNNSG SAATDSPFN