ID   STS1_YEASA              Reviewed;         318 AA.
AC   E7KDX7;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-APR-2011, sequence version 1.
DT   25-MAY-2022, entry version 34.
DE   RecName: Full=Tethering factor for nuclear proteasome STS1;
DE   AltName: Full=Dumbbell former protein 8;
DE   AltName: Full=SEC23 suppressor 1;
GN   Name=STS1; Synonyms=DBF8, SSM5; ORFNames=AWRI796_2424;
OS   Saccharomyces cerevisiae (strain AWRI796) (Baker's yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Saccharomyces.
OX   NCBI_TaxID=764097;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AWRI796;
RX   PubMed=21304888; DOI=10.1371/journal.pgen.1001287;
RA   Borneman A.R., Desany B.A., Riches D., Affourtit J.P., Forgan A.H.,
RA   Pretorius I.S., Egholm M., Chambers P.J.;
RT   "Whole-genome comparison reveals novel genetic elements that characterize
RT   the genome of industrial strains of Saccharomyces cerevisiae.";
RL   PLoS Genet. 7:E1001287-E1001287(2011).
CC   -!- FUNCTION: Involved in ubiquitin-mediated protein degradation.
CC       Regulatory factor in the ubiquitin/proteasome pathway that controls the
CC       turnover of proteasome substrates. Targets proteasomes to the nucleus
CC       and facilitates the degradation of nuclear proteins (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Binds the proteasome. Interacts with karyopherin SRP1 and
CC       Proteasome subunit RPN11. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cut8/STS1 family. {ECO:0000305}.
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DR   EMBL; ADVS01000031; EGA74477.1; -; Genomic_DNA.
DR   AlphaFoldDB; E7KDX7; -.
DR   SMR; E7KDX7; -.
DR   HOGENOM; CLU_054606_1_0_1; -.
DR   OMA; SSLGWMH; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0071630; P:nuclear protein quality control by the ubiquitin-proteasome system; IEA:InterPro.
DR   GO; GO:0031144; P:proteasome localization; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.58.1590; -; 1.
DR   InterPro; IPR013868; Cut8/Sts1_fam.
DR   InterPro; IPR038422; Cut8/Sts1_sf.
DR   PANTHER; PTHR28032; PTHR28032; 1.
DR   Pfam; PF08559; Cut8; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Protein transport; Transport.
FT   CHAIN           1..318
FT                   /note="Tethering factor for nuclear proteasome STS1"
FT                   /id="PRO_0000409440"
FT   REGION          1..75
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        9..28
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        36..53
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   318 AA;  36353 MW;  6D7E6854F2533ACB CRC64;
     MGFEWGFKPS SKITQSTVSS QGTGNVMIPT AGVKQKRRYA NEEQEEEELP RNKNVMKYGG
     VSKRRPQPGS LIRGQPLPLQ RGMELMNKNQ LQQLLVDLMT KHPEIQQSVH TRVIGLDFSI
     QKCLDMLKQK SEAVYQSIPY NRSYESNKLD DYAFVRMKPQ ILEFLNCLVD FILDNIPPRL
     ENLHASLKFL DICTELVIKL PRFELASNNY YYDKCIEQLS HVWCTLIEHV ARDRIILLAD
     NSSVWKSHMT RLQVYNEHSN GLLERPLQLF KSLDMGSPSA ASSSTLSLQE SIIYHHDTMT
     ANENNNNSGS AATDSPFN