ID   STS1_ZYGRC              Reviewed;         326 AA.
AC   C5DWK1;
DT   31-MAY-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 56.
DE   RecName: Full=Tethering factor for nuclear proteasome STS1;
GN   Name=STS1; OrderedLocusNames=ZYRO0D15488g;
OS   Zygosaccharomyces rouxii (strain ATCC 2623 / CBS 732 / NBRC 1130 / NCYC 568
OS   / NRRL Y-229) (Candida mogii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Zygosaccharomyces.
OX   NCBI_TaxID=559307;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2623 / CBS 732 / BCRC 21506 / NBRC 1130 / NCYC 568 / NRRL
RC   Y-229;
RX   PubMed=19525356; DOI=10.1101/gr.091546.109;
RG   The Genolevures Consortium;
RA   Souciet J.-L., Dujon B., Gaillardin C., Johnston M., Baret P.V.,
RA   Cliften P., Sherman D.J., Weissenbach J., Westhof E., Wincker P., Jubin C.,
RA   Poulain J., Barbe V., Segurens B., Artiguenave F., Anthouard V.,
RA   Vacherie B., Val M.-E., Fulton R.S., Minx P., Wilson R., Durrens P.,
RA   Jean G., Marck C., Martin T., Nikolski M., Rolland T., Seret M.-L.,
RA   Casaregola S., Despons L., Fairhead C., Fischer G., Lafontaine I., Leh V.,
RA   Lemaire M., de Montigny J., Neuveglise C., Thierry A., Blanc-Lenfle I.,
RA   Bleykasten C., Diffels J., Fritsch E., Frangeul L., Goeffon A.,
RA   Jauniaux N., Kachouri-Lafond R., Payen C., Potier S., Pribylova L.,
RA   Ozanne C., Richard G.-F., Sacerdot C., Straub M.-L., Talla E.;
RT   "Comparative genomics of protoploid Saccharomycetaceae.";
RL   Genome Res. 19:1696-1709(2009).
CC   -!- FUNCTION: Involved in ubiquitin-mediated protein degradation.
CC       Regulatory factor in the ubiquitin/proteasome pathway that controls the
CC       turnover of proteasome substrates. Targets proteasomes to the nucleus
CC       and facilitates the degradation of nuclear proteins (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBUNIT: Binds the proteasome. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the cut8/STS1 family. {ECO:0000305}.
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DR   EMBL; CU928176; CAR28170.1; -; Genomic_DNA.
DR   RefSeq; XP_002497103.1; XM_002497058.1.
DR   AlphaFoldDB; C5DWK1; -.
DR   SMR; C5DWK1; -.
DR   STRING; 559307.C5DWK1; -.
DR   PRIDE; C5DWK1; -.
DR   EnsemblFungi; CAR28170; CAR28170; ZYRO0D15488g.
DR   GeneID; 8204370; -.
DR   KEGG; zro:ZYRO0D15488g; -.
DR   HOGENOM; CLU_054606_1_0_1; -.
DR   InParanoid; C5DWK1; -.
DR   Proteomes; UP000008536; Chromosome D.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0071630; P:nuclear protein quality control by the ubiquitin-proteasome system; IEA:InterPro.
DR   GO; GO:0031144; P:proteasome localization; IEA:InterPro.
DR   GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.58.1590; -; 1.
DR   InterPro; IPR013868; Cut8/Sts1_fam.
DR   InterPro; IPR038422; Cut8/Sts1_sf.
DR   PANTHER; PTHR28032; PTHR28032; 1.
DR   Pfam; PF08559; Cut8; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Protein transport; Reference proteome; Transport.
FT   CHAIN           1..326
FT                   /note="Tethering factor for nuclear proteasome STS1"
FT                   /id="PRO_0000409444"
FT   REGION          51..75
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          300..326
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   326 AA;  37640 MW;  FC00687BAB96FC48 CRC64;
     MENNTAVLGA GFSWGFKSDN VMKCQEQEEQ QARENEKSLN SMVANLVQAQ GMDPKGRKRR
     LDEPTNPQPQ MMVPPRKYNV SKRRPHHSTI SGQPLPLHRG LELMSKDQLQ YILIEVMKNY
     PISQQLVQNK LVDFNFSIEK CEILLKEKLQ QLHESIPYSR SHDYQRLSDY AFVRMKPHIL
     EFLNCLVDCV LDRIPPRVDN LHESLKILDM TTDMVTKLPR FQLASNNYYY DKCLEQLACL
     WCTVIEHIAR DVIMTVNDAP LLRNWIQKLE LYNELCHGIL TKPLNQFKSL AVVDAGVTDS
     NSTKGTNATR NRWSGSTDNY TVGDNQ