ID   STTC_ASPTN              Reviewed;         299 AA.
AC   Q0CRW5;
DT   12-AUG-2020, integrated into UniProtKB/Swiss-Prot.
DT   17-OCT-2006, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=Ophiobolin family sesterterpenoid biosynthesis cluster acetyltransferase ATEG_03569 {ECO:0000303|PubMed:28604695};
DE            EC=2.3.1.- {ECO:0000305|PubMed:28604695};
DE   Flags: Precursor;
GN   ORFNames=ATEG_03569;
OS   Aspergillus terreus (strain NIH 2624 / FGSC A1156).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Circumdati.
OX   NCBI_TaxID=341663;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NIH 2624 / FGSC A1156;
RA   Birren B.W., Lander E.S., Galagan J.E., Nusbaum C., Devon K., Henn M.,
RA   Ma L.-J., Jaffe D.B., Butler J., Alvarez P., Gnerre S., Grabherr M.,
RA   Kleber M., Mauceli E.W., Brockman W., Rounsley S., Young S.K., LaButti K.,
RA   Pushparaj V., DeCaprio D., Crawford M., Koehrsen M., Engels R.,
RA   Montgomery P., Pearson M., Howarth C., Larson L., Luoma S., White J.,
RA   Alvarado L., Kodira C.D., Zeng Q., Oleary S., Yandava C., Denning D.W.,
RA   Nierman W.C., Milne T., Madden K.;
RT   "Annotation of the Aspergillus terreus NIH2624 genome.";
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION, AND PATHWAY.
RX   PubMed=28604695; DOI=10.1038/nchembio.2408;
RA   Clevenger K.D., Bok J.W., Ye R., Miley G.P., Verdan M.H., Velk T., Chen C.,
RA   Yang K., Robey M.T., Gao P., Lamprecht M., Thomas P.M., Islam M.N.,
RA   Palmer J.M., Wu C.C., Keller N.P., Kelleher N.L.;
RT   "A scalable platform to identify fungal secondary metabolites and their
RT   gene clusters.";
RL   Nat. Chem. Biol. 13:895-901(2017).
CC   -!- FUNCTION: Acetyltransferase; part of the gene cluster that mediates the
CC       biosynthesis of an ophiobolin family sesterterpenoid.
CC       {ECO:0000269|PubMed:28604695}.
CC   -!- PATHWAY: Secondary metabolite biosynthesis; terpenoid biosynthesis.
CC       {ECO:0000305|PubMed:28604695}.
CC   -!- SIMILARITY: Belongs to the bfoA family. {ECO:0000305}.
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DR   EMBL; CH476597; EAU36843.1; -; Genomic_DNA.
DR   RefSeq; XP_001212747.1; XM_001212747.1.
DR   AlphaFoldDB; Q0CRW5; -.
DR   EnsemblFungi; EAU36843; EAU36843; ATEG_03569.
DR   GeneID; 4317927; -.
DR   VEuPathDB; FungiDB:ATEG_03569; -.
DR   eggNOG; ENOG502RYTS; Eukaryota.
DR   HOGENOM; CLU_072152_0_0_1; -.
DR   OMA; PVTIDTW; -.
DR   OrthoDB; 1186411at2759; -.
DR   UniPathway; UPA00213; -.
DR   Proteomes; UP000007963; Unassembled WGS sequence.
DR   GO; GO:0016746; F:acyltransferase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016114; P:terpenoid biosynthetic process; IEA:UniProtKB-UniPathway.
PE   3: Inferred from homology;
KW   Acyltransferase; Glycoprotein; Reference proteome; Signal; Transferase.
FT   SIGNAL          1..20
FT                   /evidence="ECO:0000255"
FT   CHAIN           21..299
FT                   /note="Ophiobolin family sesterterpenoid biosynthesis
FT                   cluster acetyltransferase ATEG_03569"
FT                   /id="PRO_5004170570"
FT   CARBOHYD        28
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        58
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        77
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        126
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        177
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        212
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT   CARBOHYD        282
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   299 AA;  33669 MW;  905BF16C00E15CD7 CRC64;
     MYFFRALLSP VVMWPALVSG KSNSNTANYT VEELWDLEVT FWDNFLYPAN VKQVEAINST
     LFTTEVQGRV DITRVFNGSE LNTEYIFGLF SDPNHLSLVG VPIAYSITQF IAERNIASAT
     TVVTFNATSF GNLLLPVTID TWIMWDADGR IMQYDATFRW FGFLLDTLVE ALATSINGTA
     SQATAALTQL LATTVCDTHD KYCTGENQQY DNSTACYDFL TTAIPLGKDY ELGRDTLLCR
     EVHEHMVQYD PKMHCPHIGP TGGDYCVNDQ TYEQKVLQKY FNVSWIVGVP WTGNIWLGD