STU1_ASPFU
ID STU1_ASPFU Reviewed; 1344 AA.
AC Q4WSI0; Q6MYL4;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 25-MAY-2022, entry version 98.
DE RecName: Full=Protein stu1;
GN Name=stu1; ORFNames=AfA8D5.001c, AFUA_1G12700;
OS Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC
OS A1100) (Aspergillus fumigatus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Fumigati.
OX NCBI_TaxID=330879;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=14998527; DOI=10.1016/j.fgb.2003.12.003;
RA Pain A., Woodward J.R., Quail M.A., Anderson M.J., Clark R., Collins M.,
RA Fosker N., Fraser A., Harris D.E., Larke N., Murphy L.D., Humphray S.,
RA O'Neil S., Pertea M., Price C., Rabbinowitsch E., Rajandream M.A.,
RA Salzberg S.L., Saunders D., Seeger K., Sharp S., Warren T., Denning D.W.,
RA Barrell B.G., Hall N.;
RT "Insight into the genome of Aspergillus fumigatus: analysis of a 922 kb
RT region encompassing the nitrate assimilation gene cluster.";
RL Fungal Genet. Biol. 41:443-453(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100;
RX PubMed=16372009; DOI=10.1038/nature04332;
RA Nierman W.C., Pain A., Anderson M.J., Wortman J.R., Kim H.S., Arroyo J.,
RA Berriman M., Abe K., Archer D.B., Bermejo C., Bennett J.W., Bowyer P.,
RA Chen D., Collins M., Coulsen R., Davies R., Dyer P.S., Farman M.L.,
RA Fedorova N., Fedorova N.D., Feldblyum T.V., Fischer R., Fosker N.,
RA Fraser A., Garcia J.L., Garcia M.J., Goble A., Goldman G.H., Gomi K.,
RA Griffith-Jones S., Gwilliam R., Haas B.J., Haas H., Harris D.E.,
RA Horiuchi H., Huang J., Humphray S., Jimenez J., Keller N., Khouri H.,
RA Kitamoto K., Kobayashi T., Konzack S., Kulkarni R., Kumagai T., Lafton A.,
RA Latge J.-P., Li W., Lord A., Lu C., Majoros W.H., May G.S., Miller B.L.,
RA Mohamoud Y., Molina M., Monod M., Mouyna I., Mulligan S., Murphy L.D.,
RA O'Neil S., Paulsen I., Penalva M.A., Pertea M., Price C., Pritchard B.L.,
RA Quail M.A., Rabbinowitsch E., Rawlins N., Rajandream M.A., Reichard U.,
RA Renauld H., Robson G.D., Rodriguez de Cordoba S., Rodriguez-Pena J.M.,
RA Ronning C.M., Rutter S., Salzberg S.L., Sanchez M., Sanchez-Ferrero J.C.,
RA Saunders D., Seeger K., Squares R., Squares S., Takeuchi M., Tekaia F.,
RA Turner G., Vazquez de Aldana C.R., Weidman J., White O., Woodward J.R.,
RA Yu J.-H., Fraser C.M., Galagan J.E., Asai K., Machida M., Hall N.,
RA Barrell B.G., Denning D.W.;
RT "Genomic sequence of the pathogenic and allergenic filamentous fungus
RT Aspergillus fumigatus.";
RL Nature 438:1151-1156(2005).
CC -!- FUNCTION: Microtubule binding protein that promotes the stabilization
CC of dynamic microtubules. Required for mitotic spindle formation (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with microtubules. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus
CC {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CLASP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAF31989.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=EAL90602.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; BX649606; CAF31989.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AAHF01000004; EAL90602.1; ALT_INIT; Genomic_DNA.
DR RefSeq; XP_752640.1; XM_747547.1.
DR AlphaFoldDB; Q4WSI0; -.
DR STRING; 746128.CADAFUBP00001196; -.
DR PRIDE; Q4WSI0; -.
DR GeneID; 3510390; -.
DR KEGG; afm:AFUA_1G12700; -.
DR eggNOG; ENOG502QT5T; Eukaryota.
DR HOGENOM; CLU_004060_0_0_1; -.
DR InParanoid; Q4WSI0; -.
DR OrthoDB; 149571at2759; -.
DR Proteomes; UP000002530; Chromosome 1.
DR GO; GO:0005881; C:cytoplasmic microtubule; IBA:GO_Central.
DR GO; GO:0005815; C:microtubule organizing center; IBA:GO_Central.
DR GO; GO:0072686; C:mitotic spindle; IBA:GO_Central.
DR GO; GO:1990023; C:mitotic spindle midzone; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005876; C:spindle microtubule; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0060172; P:astral microtubule depolymerization; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0090307; P:mitotic spindle assembly; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 3.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024395; CLASP_N_dom.
DR InterPro; IPR034085; TOG.
DR Pfam; PF12348; CLASP_N; 2.
DR SMART; SM01349; TOG; 2.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Cytoplasm; Cytoskeleton; Microtubule; Mitosis;
KW Nucleus; Reference proteome; Repeat.
FT CHAIN 1..1344
FT /note="Protein stu1"
FT /id="PRO_0000272282"
FT REPEAT 93..131
FT /note="HEAT 1"
FT REPEAT 508..544
FT /note="HEAT 2"
FT REGION 265..292
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 606..638
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 651..847
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 914..945
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 984..1004
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1031..1054
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 271..292
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 674..706
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 733..774
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 775..803
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 808..847
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1344 AA; 147928 MW; F148EB15EADA6163 CRC64;
MMEVKAAELV AALKNSNMSV DTKVAHLQCV KSDIKQKNVP EGAVPSIFES IRLAIASQHS
SLSGAGFSTL GHFLKRLLIQ ELHHLVALQC RALYPLLVER LGDHKERIRA QAAQSFTDMW
LAAPEEVEQC VLGQALVGKN PRAKEMSMIW LSNVSSSFNI GGFSSFLTIA LQMTKNYGLL
FRSYVSSLVA CLEDADSNVR NTAKNTVIEL FENASERAKS DLKRQMATHN VRKSFVNAIL
ASIDHGTSDM DAASRPISRA EALVHRPVSR AETQASRSVS RLDTHQRPAS RMELAQSSVL
HTEALPPRPV SVLSSRSETH KEVTKEVIGV ERPKSRLTTA KSEPNWAVVS HTGPAEELPL
PSSRPASQEG EKIDALYVSS SRQVDELFRD MMPHFEGRES EDNWIRREKD VLTLRRLTHG
NAPDDYSPAY LAGLKTLLDG IFKVVNSLRT TLSTIGCLLI QDIAKRCGPR IDSMVEIMMQ
NLIKLCSGMK KISAQNGNAT VDALIENVTF TTRILQHVSG ACQDKNVQLR LFAAGWLKTL
IQKQSHHKSS IEHGGGLDMM EKSVKKCLAD ANPGVREAMR STFWTYYRVW PNRANEILSN
LDPKSRSLLE KDPANPNAHQ SAPKDSGPSR KGLANGTSSL AGRSALKEAI AAQKKARLAP
AKAVPPPRPE SAQSALSDKH SSAPSSSKSS VRTVPTGTSL SSLSSAPVRP AAKPRRPELN
RPATADPYAA RRSVATDSST RHGNQIDGSP SAAKSKSSTP SLKSVSSTGS RDRADPVGTT
RDRPKRLVIS KTRSHDTHTR QHSKPIPTHS RKNSNESIPR HSPLRSEFSV TPISPNSVSL
ETPSTPRSHL VQDHGNLIAI ASPPTHIQRT PIEPDASAED PREHAAKATP VAIFEDTTPA
RSDHDDIQDA AMTLTENQTP QPSKVHSDSP IVSNKRVSNQ DESVPHLTTG LGFLTGVGSV
VEASELPNSD AQTDQSLFAD HSLPVTHQPD SVTDSSKPSG LSSSLMVAGS PIRVANNENE
IVIDSKTTHV SLPHRSSPKH NVLGELTSNE PSQRANKQIR HAANKLEDEV TTPIDDHSRH
RWKKVEIADR RTSISPRSKD PTKAQQMLDK GIQRIRTKTM DILGYRKLQG IIKYHDSIFT
NEEKYDEMLL ALLDELESSP DDKRQPLGRP LDLKTQVLLT IRLMLIHNKI YFSAYCSRAL
GALVLARKYY DANCHIVSGL EETADDIIAL CEPAAVIDSV LDVIITEEKD DREYRSILMG
VSVLTRILSR LNADKCRVPE LPLDRLGQFA ASKLADRQPD VRRLAVQLCV QLHGMVANEE
EYWRVLGHPR ENSRNLLTYY ILKK
