STU1_ASPOR
ID STU1_ASPOR Reviewed; 1184 AA.
AC Q2UCC9;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=Protein stu1;
GN Name=stu1; ORFNames=AO090012000643;
OS Aspergillus oryzae (strain ATCC 42149 / RIB 40) (Yellow koji mold).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=510516;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 42149 / RIB 40;
RX PubMed=16372010; DOI=10.1038/nature04300;
RA Machida M., Asai K., Sano M., Tanaka T., Kumagai T., Terai G., Kusumoto K.,
RA Arima T., Akita O., Kashiwagi Y., Abe K., Gomi K., Horiuchi H.,
RA Kitamoto K., Kobayashi T., Takeuchi M., Denning D.W., Galagan J.E.,
RA Nierman W.C., Yu J., Archer D.B., Bennett J.W., Bhatnagar D.,
RA Cleveland T.E., Fedorova N.D., Gotoh O., Horikawa H., Hosoyama A.,
RA Ichinomiya M., Igarashi R., Iwashita K., Juvvadi P.R., Kato M., Kato Y.,
RA Kin T., Kokubun A., Maeda H., Maeyama N., Maruyama J., Nagasaki H.,
RA Nakajima T., Oda K., Okada K., Paulsen I., Sakamoto K., Sawano T.,
RA Takahashi M., Takase K., Terabayashi Y., Wortman J.R., Yamada O.,
RA Yamagata Y., Anazawa H., Hata Y., Koide Y., Komori T., Koyama Y.,
RA Minetoki T., Suharnan S., Tanaka A., Isono K., Kuhara S., Ogasawara N.,
RA Kikuchi H.;
RT "Genome sequencing and analysis of Aspergillus oryzae.";
RL Nature 438:1157-1161(2005).
CC -!- FUNCTION: Microtubule binding protein that promotes the stabilization
CC of dynamic microtubules. Required for mitotic spindle formation (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with microtubules. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus
CC {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CLASP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAE60786.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AP007161; BAE60786.1; ALT_INIT; Genomic_DNA.
DR AlphaFoldDB; Q2UCC9; -.
DR STRING; 510516.Q2UCC9; -.
DR EnsemblFungi; BAE60786; BAE60786; AO090012000643.
DR Proteomes; UP000006564; Chromosome 4.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; -; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024395; CLASP_N_dom.
DR InterPro; IPR034085; TOG.
DR Pfam; PF12348; CLASP_N; 2.
DR SMART; SM01349; TOG; 2.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Cytoplasm; Cytoskeleton; Microtubule; Mitosis;
KW Nucleus; Reference proteome; Repeat.
FT CHAIN 1..1184
FT /note="Protein stu1"
FT /id="PRO_0000272283"
FT REPEAT 92..130
FT /note="HEAT 1"
FT REPEAT 162..194
FT /note="HEAT 2"
FT REPEAT 463..499
FT /note="HEAT 3"
FT REGION 229..336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 564..584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 602..906
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 570..584
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 613..644
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 721..745
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 748..906
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1184 AA; 132061 MW; 97D0D78381B7348A CRC64;
MEGKATELLA VLKNNNLAID VKVSHLLSIK SDIKQKNVPD NAVHLIFESL RLAITSHHAA
LYAAGFSTFG HFLKRLFIQD QAHIVSAYAR HFCPVLLERL GDHKERVRAQ AAQIFTDLWP
AASADVEHYV LEVALTGKNP KAKETSLIWL SNMSRNHGLL FRSYVPSVVS CLEDADSFVR
HTAKSTVVEL FQGAPARAKA DLTKEMTAQN VRQSIVNAVY ANIGLEDHSS TARPRSRVEP
RYTPCTDSHP LRSASRAEVV HQQPAAVVSS APLRPSKEAT PMVEPEPIKS RPGSSKSDKG
RTIAAAPEAE KAPHMETARP SSQDGEAPQP LHAETSKQVE DLFRVLSPAF EGRESEDNWR
HREKYITSLR RLTYGNAPHD FPQPFFTGIK TNLDGIFKAV NSLRTTLSTN GCLLIQDLAK
IGGSRIDPMV EVIMQNLIKL CGGMKKISAQ NGNVSVNDVL ANVTYTPRLL QHVTSACQDK
NAQLRLFAAG WLKTLLNKQS HHKSSLEHGG GLALLEKSLK RGLTDANPGI REAMRGAFWT
FHQMWPARGN NILSDLDNKT RHLLEKDPAN PNRDQSSYLS SDTLTVPSRS ALKEAIAAHK
KARLAPAKTL PPRPESAQSS FSETKVSDPP AKSTGRTARA PLSSLSSAPM RPGAKPRRPE
LARPATADPY SSRKTAATDA VHIDSSPRPR RVANLGQAPS STKSKPKKLD IPMTMAVDPV
APSASNENET QVATQVASKV RKRSSLSEQF AAIKRDDRDI NALSELSINK TEHPHEIAVG
ESSNNEAGRH DDHAPCEISF DKLDRHDENK LSESPTPGPD HHDENALGEL SINVPDRRDE
TALGELSINK PQRRDENALG ELSINKLDRR DENTPSKSPP SEQDRRVEKT IDSAEHTSQA
QRRVEESEPY FARFKIRSRL SNKRRNISPH SEHLENAKEM VRVAGQRIRS RSFDLFAYRK
LQDLIHYHGE KLFTRPVFDD LLDGLLVELR KEPSPDRKHN GDYADVKTQV VGTLRLLEKS
CPNLFVIDYD AIDAIFHARR YFETNSWIVQ ELQQTALEWF RNCEPSKLEG MLDTLVQYVQ
RETRDEPGYR SILMALSLLT DLIGDANKKG AWFSNEILEQ VGTIAARDIL AEDTDIRKKS
IELCVQLYVM STNLYQDKGV SFWRLVKAPE GGTRQLIMYY IARQ
