STU1_CANAL
ID STU1_CANAL Reviewed; 1303 AA.
AC Q59WD5; A0A1D8PE19;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2005, sequence version 1.
DT 03-AUG-2022, entry version 96.
DE RecName: Full=Protein STU1;
GN Name=STU1; OrderedLocusNames=CAALFM_C107360WA;
GN ORFNames=CaO19.11914, CaO19.4435;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- FUNCTION: Microtubule binding protein that promotes the stabilization
CC of dynamic microtubules. Required for mitotic spindle formation (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with microtubules. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus
CC {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CLASP family. {ECO:0000305}.
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DR EMBL; CP017623; AOW26384.1; -; Genomic_DNA.
DR RefSeq; XP_713879.1; XM_708786.2.
DR AlphaFoldDB; Q59WD5; -.
DR BioGRID; 1227361; 1.
DR STRING; 237561.Q59WD5; -.
DR PRIDE; Q59WD5; -.
DR GeneID; 3644470; -.
DR KEGG; cal:CAALFM_C107360WA; -.
DR CGD; CAL0000197796; orf19.11914.
DR VEuPathDB; FungiDB:C1_07360W_A; -.
DR eggNOG; ENOG502QT5T; Eukaryota.
DR HOGENOM; CLU_261691_0_0_1; -.
DR InParanoid; Q59WD5; -.
DR OMA; RNYQPRS; -.
DR OrthoDB; 513064at2759; -.
DR PRO; PR:Q59WD5; -.
DR Proteomes; UP000000559; Chromosome 1.
DR GO; GO:0005881; C:cytoplasmic microtubule; IBA:GO_Central.
DR GO; GO:0005815; C:microtubule organizing center; IBA:GO_Central.
DR GO; GO:0072686; C:mitotic spindle; IBA:GO_Central.
DR GO; GO:1990023; C:mitotic spindle midzone; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005876; C:spindle microtubule; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0060172; P:astral microtubule depolymerization; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0090307; P:mitotic spindle assembly; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024395; CLASP_N_dom.
DR InterPro; IPR034085; TOG.
DR Pfam; PF12348; CLASP_N; 1.
DR SMART; SM01349; TOG; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Cytoplasm; Cytoskeleton; Microtubule; Mitosis;
KW Nucleus; Reference proteome.
FT CHAIN 1..1303
FT /note="Protein STU1"
FT /id="PRO_0000272284"
FT REGION 239..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 531..664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 953..977
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 555..572
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 573..596
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 614..632
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 633..652
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 953..976
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1303 AA; 147253 MW; AC93A89784EDB070 CRC64;
MSTTKFNSIS PIELLEIISS YDIQDEIKLS HIQNLKTHIK KDTIDLRNVP IYLQIITKGL
EITRLNISSV SFNSLSYLIK RISVQDKSGN ILKEECFLIL PILINKLGNA SSPAGTNSAK
KSLEDYWLSS PIEVEDALTE IAFENPNTKI TIETIDWMTQ ILKNISAKFN VPKFLPKILH
SIEINPHNEE IIVSTKELLS IYLEKNPSAI EGFKKQIESH SLAQATKDKL LGSVISKLRG
SDPEPHVQRA NTPRSNTPVS QIQSSLVDVG HDVELLELLN KVNYEIDSSI KALDIRDANS
LFNTFEIFMP CFDGKETESN WKVREKNILQ MRSILRGNSA TQFRSELVQC IHTIANGMCK
GASSLRTTLS SNSCQLIKEC AVILKKSLEP VAESLFPTLI KLCSSTKNIA STNANMSVAA
LYANLPYTSK MIQRITLASE DRNYQPRSYS LIWLHILLLK IGIDRSYIGH HDSSFIEAAN
KVFMKLLKDA NPNVRQTAKE CYWCFTRVFP EDAERLLKRL EPNIVRALER SQRESGGSGI
APIRTLSSRP SRPSLKEAIL EKNKELRQRR PPSRNSGEQS TKIKSVPLPR PTKSSSRLEK
SLLRPDVGHK SQPAVRASSW TYPSTQSGPK ATFKQRERSK TEVHKKSPLE ISRPSSRLDT
GAVSSFNNKN DPMINFLSSS DSDLIKEGIN LLKYAIIGKE NLPSEINSLL KSISEKHVQF
MKPLFTSNDY TFKKAASLLL PDDFLRVCAL VFDEFDEAVI SLIIQCIDVS TFYESACNLL
TLVADTPNIP GSHALVMQIS NQKLTITKSI LQALSIALSK HAVTDVQFGE IFQELVKLII
VLKATDYYSL LCQLFRQLYT IDSNKFSLLV EDVEGKLKEE VEFIVGIEST MTLERPSSKL
DYDLTVVKPT SNLGTFVLSQ KPSADDFTML LPKRSEFLGS GEVYNSKMVA KIEASDSSPQ
KQSQMDQISS KRSNSEHQSE VLVDDFANVS IADGGGSKLN QSKNDDDNLK QFMERIDPLK
PISNKIRKIS IYEDAKQNSE KPKLERNWGG FQYAKFSRAI RVNAVAENMS LTSQEFESCC
SKLVETPSQS ALLKMTWFVD SLSVSSYDYQ EFFLNKGKHK LEKSLWEFFS KIDKSDHSLV
MNGLFLLKQL LKFNDTPNVD KLFALLVDTC SQEELDSELY FIWNEMLLSL NHDELMKSFE
KNALNYLEGE ENNLTISSLC LNYLAKVLVD DNCLDVAKIY RLDTIFGKLF HEREVMFRKS
ATICYSNLLK NTNVSPEVKD TLDKVKSRYP ASTQRLIEFY MKR
