ID   STU1_COCIM              Reviewed;        1244 AA.
AC   Q1DS65; J3K9S6;
DT   23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 2.
DT   03-AUG-2022, entry version 79.
DE   RecName: Full=Protein STU1;
GN   Name=STU1; ORFNames=CIMG_06848;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: Microtubule binding protein that promotes the stabilization
CC       of dynamic microtubules. Required for mitotic spindle formation (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with microtubules. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus
CC       {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CLASP family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; GG704912; EAS31369.3; -; Genomic_DNA.
DR   RefSeq; XP_001242952.2; XM_001242951.2.
DR   AlphaFoldDB; Q1DS65; -.
DR   STRING; 246410.Q1DS65; -.
DR   PRIDE; Q1DS65; -.
DR   EnsemblFungi; EAS31369; EAS31369; CIMG_06848.
DR   GeneID; 4562036; -.
DR   KEGG; cim:CIMG_06848; -.
DR   VEuPathDB; FungiDB:CIMG_06848; -.
DR   InParanoid; Q1DS65; -.
DR   OMA; TMSTNGC; -.
DR   OrthoDB; 149571at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR   GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   Gene3D; 1.25.10.10; -; 3.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR024395; CLASP_N_dom.
DR   InterPro; IPR034085; TOG.
DR   Pfam; PF12348; CLASP_N; 2.
DR   SMART; SM01349; TOG; 2.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cytoplasm; Cytoskeleton; Microtubule; Mitosis;
KW   Nucleus; Reference proteome; Repeat.
FT   CHAIN           1..1244
FT                   /note="Protein STU1"
FT                   /id="PRO_0000272286"
FT   REPEAT          87..124
FT                   /note="HEAT 1"
FT   REPEAT          159..196
FT                   /note="HEAT 2"
FT   REPEAT          1038..1075
FT                   /note="HEAT 3"
FT   REPEAT          1126..1163
FT                   /note="HEAT 4"
FT   REGION          232..326
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          561..758
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          795..998
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        232..248
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        288..317
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        569..596
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        603..624
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        638..659
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        682..717
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        820..834
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        940..971
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        972..994
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1244 AA;  137113 MW;  3B2E2DC3D27D1288 CRC64;
     MDARATELLA TLRNGNVSVD VKTTSLAKLK SEIKQKHVPD AAISPLFESF RLAIASQHYS
     LSSAGFSALG HLLKRLTLQE QHEAIALQGR ATYQLLLERL GDHKERIRSQ AAQAFTDFWP
     AASADVEHHV LGAALIGKNA RAKETSMVWL AKMTREYGLL FRIYVPALVT CLEDADGVVR
     DTAKSTVIEL FQSAPPRAIS DLKKQLIQNN VRKSIATSIL SSLGANIVAD SETSSSFQSQ
     SRSDITRPAT SFSHRREEVP RSQSVLSMRS HSNADVHNIP KIDAAFKSQS KPTRSGHSSK
     DPTLSHTASS ESLPAPRQDT TDGEGVEPLY INSHREFDDT IREMLPHFEG KESEQNWILR
     EKSIMTLRRL TKGNAPHDYQ QYYLAGIKSV LDGILKTANS LRTTLSAAGC YLLQDIARTC
     GPAIDPMVEI LLQSLIKLSA ALKKITAQNG NVTVDVIIGN VSYTARILQH IWGACQDKNV
     QPRQFATGWI KTIIIRQGKH KGSIEHSGGL DLIEKCIKKG LGDPNPGVRE GMRGTFWAFY
     SVWPERADVI MSALEPKSKN LLERDPNNTH RGVASQSFDG SRGSQPHSTK SSLKEAINAQ
     KKARLAASSN VPSRPESAQS SFPDPKSGRP APRRPTGTST IRVPTGEKLS QSASLSSAPM
     RPASRPRRPE LVRPATADPY SSRRSAAPTA QSKASSPSDS PQKSKSKLMT TPRSRNPLAR
     PKSRMDNAAN VTNDKQRADP AATLAPKMRR RGPSEPDVVS AAARARIAIL SPSRTEGDFS
     VASSQVKIDQ KAEEAFQGTP TRGIENGTPL PASPLRSPLK GAFSTPTRNR KSSDGAPPSR
     IPISPSYSSR RSSEEPMLPR TPLDSRRSRG ESDEAASQIP APVDQSPIID AINSQSPGIL
     KVYEDPQSPH SKHSIVLGDT VPKTPGSQAK VMPLEELPLN ESTTVPNRKH NQLPEHTPLL
     QPSPILTPSS ENSHRRWKKV EGSERRRSLS PRSKDPVKAQ DMITRGLARI RTGALDVHGY
     RKFQNLIKYH ESISKDDTKY EDILMALLEA LEKPDGDKGA PSGRSLDLKT QVLVTIRLML
     VINREAFAAF YPRVMTAIIT ARKQYELTNH IVSGLEETAE DIVSACNPPQ VIDAILDLLE
     TEERSFESYR MVAMGSYILS GLLRRLNNQK LYLSQAELER LGKFANENLR STQPDVRRAI
     IDFCPELYDM VQSEDAFWSM VNSSVEDFRP LLTYYIMRRP EKIG