STU1_CRYNB
ID STU1_CRYNB Reviewed; 1242 AA.
AC P0CM75; Q55WM6; Q5KJL9;
DT 28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT 28-JUN-2011, sequence version 1.
DT 25-MAY-2022, entry version 46.
DE RecName: Full=Protein STU1;
GN Name=STU1; OrderedLocusNames=CNBC1130;
OS Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)
OS (Filobasidiella neoformans).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC Tremellales; Cryptococcaceae; Cryptococcus;
OC Cryptococcus neoformans species complex.
OX NCBI_TaxID=283643;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B-3501A;
RX PubMed=15653466; DOI=10.1126/science.1103773;
RA Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT neoformans.";
RL Science 307:1321-1324(2005).
CC -!- FUNCTION: Microtubule binding protein that promotes the stabilization
CC of dynamic microtubules. Required for mitotic spindle formation (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with microtubules. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus
CC {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CLASP family. {ECO:0000305}.
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DR EMBL; AAEY01000013; EAL21973.1; -; Genomic_DNA.
DR RefSeq; XP_776620.1; XM_771527.1.
DR AlphaFoldDB; P0CM75; -.
DR EnsemblFungi; EAL21973; EAL21973; CNBC1130.
DR GeneID; 4934777; -.
DR KEGG; cnb:CNBC1130; -.
DR VEuPathDB; FungiDB:CNBC1130; -.
DR HOGENOM; CLU_003840_0_0_1; -.
DR Proteomes; UP000001435; Chromosome 3.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; -; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024395; CLASP_N_dom.
DR Pfam; PF12348; CLASP_N; 1.
DR SUPFAM; SSF48371; SSF48371; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Cytoplasm; Cytoskeleton; Microtubule; Mitosis;
KW Nucleus.
FT CHAIN 1..1242
FT /note="Protein STU1"
FT /id="PRO_0000410040"
FT REGION 138..161
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 538..612
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 637..711
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 748..839
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 853..884
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1077..1111
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 138..159
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 550..572
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 577..593
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 637..694
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 748..769
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 770..790
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 799..839
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 853..874
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1080..1104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1242 AA; 135985 MW; 60664E891D4FF166 CRC64;
MPKTLTESEV EATFAKLKAA DPDRKVDIIQ FFGLQLEDVE ELPASVIDPF LLILPPLIRS
PHSLLLSSVL SSFLPYFLPL IPKHPTTHLR LALLQVLPAL LEKLNDAKER IHSAAGNAIV
ILGELSWEAE PPIPASNLNS SGSLKAGSLS SSTATKSKPH ETLPHLWERH LKDVLQGKAW
RSKVEGMKVL TKMRSKEGAK MGLKAWLGVL VDLLEDGDGN VRDQARETVV ELLSPPSTPP
AARSEFKRLL VARNVRKTIA DDIITRILSG EGSDRSTPAV MNSELGKEEG ASRSGAAAPA
HSQADDVDIV YVASPQDLER EFHSMLPFFE GKETEENWAP RERSIVRIRG MMKGQAHVKY
QAAFIAGLKG GIVLSLRTTV AQQSCYLLKE LPEGLGAAFD NFVEFLLPIL GKMSGFTKKL
IADRSQTAVT SIITHTTVHP RIFINHISSG IQEKNVQIRA YSVNHLKTFL IVHASHAKHQ
IEATPGLSDT LDAAFRKALA DVNPGVREVT RQAFWRYHEV WRSKAEVLMN SLDGQARKQL
EKANPRTAAS PMPSYASSSS TGAPSSANTK PPSKKMDLKA MLAERRRAVK EAGKQAQETN
AGSPRVVSNP VFASPGVQHA SITGLPRSSS AVGIARHVET SSPSPVRSPT PSSSATRIRP
SPSPERIQSP IQTKIEIDSP LRSRYTSLTP DLARSPPKSP SPSLSPSLGL GESPLRQVLT
YPAANGRHSV GEGKRAIPEL VEVADNGAEH EVDELTLKEG QKTRDDGNTD QELPPTVQEE
VDQVEQSQQF ESEPRLEHPE PQQGNTFSTS TSGRVPSTPA RSIATGTTAS LPNSRNGNIK
GEKIISSRLN PEAFQTPLNP KTSALRSSSA IRTPAWKDSP RPEAVTPQMM QKLKERRHER
SWWVKRQELL EKASPLKPLT PSPSFAILPD IEALELGAPT LKNLQKIALF CSSHPVRPEP
TAEQDEEEKR AFEEEKRVWT GLFDRVMNGV VDFLRPDKDK ELLEQGLVVL WEIVQHQWPL
VDDTQRLCHG LFRLRESSDA VVLESTNALI SLLVQISDPM LLLCNLRSSL DRFLTKHPAP
PSSSADNSDP MTSALSQLSL SSSKESPEKR TRNSGYLFGL TSIGMCVLRL SAPVIVSEGP
KLGQIVMEAI NDPSSIIRQA AHSLLLAIQC VTHDSRKTLA FVPAMSQGQK DLAVYYMAQN
GVLEQIGLHK KATSEGEKGR EGDRDNMTGE LAGLMSRGVI RE
