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STU1_CRYNJ
ID   STU1_CRYNJ              Reviewed;        1242 AA.
AC   P0CM74; Q55WM6; Q5KJL9;
DT   28-JUN-2011, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 50.
DE   RecName: Full=Protein STU1;
GN   Name=STU1; OrderedLocusNames=CNC06070;
OS   Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC
OS   MYA-565) (Filobasidiella neoformans).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Agaricomycotina; Tremellomycetes;
OC   Tremellales; Cryptococcaceae; Cryptococcus;
OC   Cryptococcus neoformans species complex.
OX   NCBI_TaxID=214684;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JEC21 / ATCC MYA-565;
RX   PubMed=15653466; DOI=10.1126/science.1103773;
RA   Loftus B.J., Fung E., Roncaglia P., Rowley D., Amedeo P., Bruno D.,
RA   Vamathevan J., Miranda M., Anderson I.J., Fraser J.A., Allen J.E.,
RA   Bosdet I.E., Brent M.R., Chiu R., Doering T.L., Donlin M.J., D'Souza C.A.,
RA   Fox D.S., Grinberg V., Fu J., Fukushima M., Haas B.J., Huang J.C.,
RA   Janbon G., Jones S.J.M., Koo H.L., Krzywinski M.I., Kwon-Chung K.J.,
RA   Lengeler K.B., Maiti R., Marra M.A., Marra R.E., Mathewson C.A.,
RA   Mitchell T.G., Pertea M., Riggs F.R., Salzberg S.L., Schein J.E.,
RA   Shvartsbeyn A., Shin H., Shumway M., Specht C.A., Suh B.B., Tenney A.,
RA   Utterback T.R., Wickes B.L., Wortman J.R., Wye N.H., Kronstad J.W.,
RA   Lodge J.K., Heitman J., Davis R.W., Fraser C.M., Hyman R.W.;
RT   "The genome of the basidiomycetous yeast and human pathogen Cryptococcus
RT   neoformans.";
RL   Science 307:1321-1324(2005).
CC   -!- FUNCTION: Microtubule binding protein that promotes the stabilization
CC       of dynamic microtubules. Required for mitotic spindle formation (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with microtubules. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus
CC       {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CLASP family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAW42562.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AE017343; AAW42562.1; ALT_SEQ; Genomic_DNA.
DR   RefSeq; XP_569869.1; XM_569869.1.
DR   AlphaFoldDB; P0CM74; -.
DR   STRING; 5207.AAW42562; -.
DR   PaxDb; P0CM74; -.
DR   PRIDE; P0CM74; -.
DR   eggNOG; ENOG502QT5T; Eukaryota.
DR   InParanoid; P0CM74; -.
DR   OrthoDB; 962965at2759; -.
DR   Proteomes; UP000002149; Chromosome 3.
DR   GO; GO:0005881; C:cytoplasmic microtubule; IBA:GO_Central.
DR   GO; GO:0005815; C:microtubule organizing center; IBA:GO_Central.
DR   GO; GO:0072686; C:mitotic spindle; IBA:GO_Central.
DR   GO; GO:1990023; C:mitotic spindle midzone; IBA:GO_Central.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005876; C:spindle microtubule; IBA:GO_Central.
DR   GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR   GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR   GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR   GO; GO:0090307; P:mitotic spindle assembly; IBA:GO_Central.
DR   Gene3D; 1.25.10.10; -; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR024395; CLASP_N_dom.
DR   Pfam; PF12348; CLASP_N; 1.
DR   SUPFAM; SSF48371; SSF48371; 1.
PE   3: Inferred from homology;
KW   Cell cycle; Cell division; Cytoplasm; Cytoskeleton; Microtubule; Mitosis;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..1242
FT                   /note="Protein STU1"
FT                   /id="PRO_0000272287"
FT   REGION          138..161
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          538..612
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          637..711
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          748..839
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          853..884
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1077..1111
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        138..159
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        550..572
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        577..593
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        637..694
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        748..769
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        770..790
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        799..839
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        853..874
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1080..1104
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1242 AA;  135985 MW;  60664E891D4FF166 CRC64;
     MPKTLTESEV EATFAKLKAA DPDRKVDIIQ FFGLQLEDVE ELPASVIDPF LLILPPLIRS
     PHSLLLSSVL SSFLPYFLPL IPKHPTTHLR LALLQVLPAL LEKLNDAKER IHSAAGNAIV
     ILGELSWEAE PPIPASNLNS SGSLKAGSLS SSTATKSKPH ETLPHLWERH LKDVLQGKAW
     RSKVEGMKVL TKMRSKEGAK MGLKAWLGVL VDLLEDGDGN VRDQARETVV ELLSPPSTPP
     AARSEFKRLL VARNVRKTIA DDIITRILSG EGSDRSTPAV MNSELGKEEG ASRSGAAAPA
     HSQADDVDIV YVASPQDLER EFHSMLPFFE GKETEENWAP RERSIVRIRG MMKGQAHVKY
     QAAFIAGLKG GIVLSLRTTV AQQSCYLLKE LPEGLGAAFD NFVEFLLPIL GKMSGFTKKL
     IADRSQTAVT SIITHTTVHP RIFINHISSG IQEKNVQIRA YSVNHLKTFL IVHASHAKHQ
     IEATPGLSDT LDAAFRKALA DVNPGVREVT RQAFWRYHEV WRSKAEVLMN SLDGQARKQL
     EKANPRTAAS PMPSYASSSS TGAPSSANTK PPSKKMDLKA MLAERRRAVK EAGKQAQETN
     AGSPRVVSNP VFASPGVQHA SITGLPRSSS AVGIARHVET SSPSPVRSPT PSSSATRIRP
     SPSPERIQSP IQTKIEIDSP LRSRYTSLTP DLARSPPKSP SPSLSPSLGL GESPLRQVLT
     YPAANGRHSV GEGKRAIPEL VEVADNGAEH EVDELTLKEG QKTRDDGNTD QELPPTVQEE
     VDQVEQSQQF ESEPRLEHPE PQQGNTFSTS TSGRVPSTPA RSIATGTTAS LPNSRNGNIK
     GEKIISSRLN PEAFQTPLNP KTSALRSSSA IRTPAWKDSP RPEAVTPQMM QKLKERRHER
     SWWVKRQELL EKASPLKPLT PSPSFAILPD IEALELGAPT LKNLQKIALF CSSHPVRPEP
     TAEQDEEEKR AFEEEKRVWT GLFDRVMNGV VDFLRPDKDK ELLEQGLVVL WEIVQHQWPL
     VDDTQRLCHG LFRLRESSDA VVLESTNALI SLLVQISDPM LLLCNLRSSL DRFLTKHPAP
     PSSSADNSDP MTSALSQLSL SSSKESPEKR TRNSGYLFGL TSIGMCVLRL SAPVIVSEGP
     KLGQIVMEAI NDPSSIIRQA AHSLLLAIQC VTHDSRKTLA FVPAMSQGQK DLAVYYMAQN
     GVLEQIGLHK KATSEGEKGR EGDRDNMTGE LAGLMSRGVI RE
 
 
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