STU1_EMENI
ID STU1_EMENI Reviewed; 1261 AA.
AC Q5BEN5; C8VU72;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 25-MAY-2022, entry version 94.
DE RecName: Full=Protein stu1;
GN Name=stu1; ORFNames=AN0995;
OS Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 /
OS M139) (Aspergillus nidulans).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Nidulantes.
OX NCBI_TaxID=227321;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=16372000; DOI=10.1038/nature04341;
RA Galagan J.E., Calvo S.E., Cuomo C., Ma L.-J., Wortman J.R., Batzoglou S.,
RA Lee S.-I., Bastuerkmen M., Spevak C.C., Clutterbuck J., Kapitonov V.,
RA Jurka J., Scazzocchio C., Farman M.L., Butler J., Purcell S., Harris S.,
RA Braus G.H., Draht O., Busch S., D'Enfert C., Bouchier C., Goldman G.H.,
RA Bell-Pedersen D., Griffiths-Jones S., Doonan J.H., Yu J., Vienken K.,
RA Pain A., Freitag M., Selker E.U., Archer D.B., Penalva M.A., Oakley B.R.,
RA Momany M., Tanaka T., Kumagai T., Asai K., Machida M., Nierman W.C.,
RA Denning D.W., Caddick M.X., Hynes M., Paoletti M., Fischer R., Miller B.L.,
RA Dyer P.S., Sachs M.S., Osmani S.A., Birren B.W.;
RT "Sequencing of Aspergillus nidulans and comparative analysis with A.
RT fumigatus and A. oryzae.";
RL Nature 438:1105-1115(2005).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139;
RX PubMed=19146970; DOI=10.1016/j.fgb.2008.12.003;
RA Wortman J.R., Gilsenan J.M., Joardar V., Deegan J., Clutterbuck J.,
RA Andersen M.R., Archer D., Bencina M., Braus G., Coutinho P., von Dohren H.,
RA Doonan J., Driessen A.J., Durek P., Espeso E., Fekete E., Flipphi M.,
RA Estrada C.G., Geysens S., Goldman G., de Groot P.W., Hansen K.,
RA Harris S.D., Heinekamp T., Helmstaedt K., Henrissat B., Hofmann G.,
RA Homan T., Horio T., Horiuchi H., James S., Jones M., Karaffa L.,
RA Karanyi Z., Kato M., Keller N., Kelly D.E., Kiel J.A., Kim J.M.,
RA van der Klei I.J., Klis F.M., Kovalchuk A., Krasevec N., Kubicek C.P.,
RA Liu B., Maccabe A., Meyer V., Mirabito P., Miskei M., Mos M., Mullins J.,
RA Nelson D.R., Nielsen J., Oakley B.R., Osmani S.A., Pakula T., Paszewski A.,
RA Paulsen I., Pilsyk S., Pocsi I., Punt P.J., Ram A.F., Ren Q., Robellet X.,
RA Robson G., Seiboth B., van Solingen P., Specht T., Sun J.,
RA Taheri-Talesh N., Takeshita N., Ussery D., vanKuyk P.A., Visser H.,
RA van de Vondervoort P.J., de Vries R.P., Walton J., Xiang X., Xiong Y.,
RA Zeng A.P., Brandt B.W., Cornell M.J., van den Hondel C.A., Visser J.,
RA Oliver S.G., Turner G.;
RT "The 2008 update of the Aspergillus nidulans genome annotation: a community
RT effort.";
RL Fungal Genet. Biol. 46:S2-13(2009).
CC -!- FUNCTION: Microtubule binding protein that promotes the stabilization
CC of dynamic microtubules. Required for mitotic spindle formation (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with microtubules. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus
CC {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CLASP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CBF88373.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=EAA65563.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AACD01000015; EAA65563.1; ALT_INIT; Genomic_DNA.
DR EMBL; BN001308; CBF88373.1; ALT_INIT; Genomic_DNA.
DR RefSeq; XP_658599.1; XM_653507.1.
DR AlphaFoldDB; Q5BEN5; -.
DR STRING; 162425.CADANIAP00001655; -.
DR PRIDE; Q5BEN5; -.
DR EnsemblFungi; EAA65563; EAA65563; AN0995.2.
DR GeneID; 2876774; -.
DR KEGG; ani:AN0995.2; -.
DR VEuPathDB; FungiDB:AN0995; -.
DR eggNOG; ENOG502QT5T; Eukaryota.
DR HOGENOM; CLU_004060_0_0_1; -.
DR InParanoid; Q5BEN5; -.
DR OrthoDB; 149571at2759; -.
DR Proteomes; UP000000560; Chromosome VIII.
DR Proteomes; UP000005890; Unassembled WGS sequence.
DR GO; GO:0005881; C:cytoplasmic microtubule; IBA:GO_Central.
DR GO; GO:0005815; C:microtubule organizing center; IBA:GO_Central.
DR GO; GO:0072686; C:mitotic spindle; IBA:GO_Central.
DR GO; GO:1990023; C:mitotic spindle midzone; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005876; C:spindle microtubule; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0060172; P:astral microtubule depolymerization; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0090307; P:mitotic spindle assembly; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024395; CLASP_N_dom.
DR InterPro; IPR021133; HEAT_type_2.
DR InterPro; IPR034085; TOG.
DR Pfam; PF12348; CLASP_N; 2.
DR SMART; SM01349; TOG; 2.
DR SUPFAM; SSF48371; SSF48371; 1.
DR PROSITE; PS50077; HEAT_REPEAT; 1.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Cytoplasm; Cytoskeleton; Microtubule; Mitosis;
KW Nucleus; Reference proteome; Repeat.
FT CHAIN 1..1261
FT /note="Protein stu1"
FT /id="PRO_0000272289"
FT REPEAT 92..130
FT /note="HEAT"
FT REGION 238..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 671..833
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 883..984
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 690..719
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 763..781
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 793..833
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 883..943
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 954..981
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1261 AA; 139824 MW; BC1616E685B663DB CRC64;
MDYKARDILS VLKNVNLSVD AKVTHLLGLK SDIKQKNVPE KAVPVIFECL RHAIASPFHA
LYSAGFSTLG HFLKRLYIQE HHQLVAAMSD RILPTLVDRM GDNKDRIRQQ TTHALADLWE
GAGPQIENLV LSVGFQGKNP FQKQTCLNLL SIAFTRSEIT AAYAEATAKE YLPQIISFVE
DADPTVRQGA RALLVQMFIG ERDSSKHELK RALEQYKVRP SHAREILAGI GLDPELYDES
HSSRQHSIQQ RAPSRAATAS RAPSRAGISR APSRAAISRA ASRADISRAP SRADTFDERS
GSTTTHVDSS SAADDGAPVL HHPKPVRTSP VTGGMIAASD NRIAVTDSIP ANDFDSPKQK
NTLRTNASKA SGMVNAPAGH AAAPSALGHA VEKAKRAVEP LDIEPYDLSS SQELDRLQAT
MAPWFEGRET EMNFQRREEY TILIRRITHG NAPQRWPTAY LGFVKMTLPF VFITANSVRT
SLQTAGLRAV QSLARVNKER LDSSIHIVLQ NVLKLCANAK GITSQNSNLT IVAILENVTC
NQRVLNQITG AAKDKNQNMR IFSAGWLEII IDGQNRHKTH AEGVNSIAAC IQEGVEDAKE
DIRRAYRHTF FRFSSVWPAR AKKILDAVSP KTQKLIEKDM LKMSEDPFVS NSGSSATGLF
SSTPARAAAK GVTTEKGKAS IAVPKAMSSP KLASRSTQPV TTKTNTLQKK PTSTLSSAPM
RPGAAKPRPA TAAGFQLKKK ENESPRKKQT PSRVPEPGLD TPITRRRQNS DPTQNESPTK
SGWVAHAADD HHIGPLTIPK RRSTRDTETP RAKASKQADI EVEMDDKNYD GRADEIVQEK
VNETVYETVD EMVDERANER VDEYFDEHVD ERIDEMVREK VDEKVDEEVD EKVDEKVDEK
VDEKVDEKAD EKVDEKVDEK VNEKVDSAAD DNLQEEVAEK RSMSLSDEII ASAQRPSDEV
KERSSEAERA SMGKGGSPRP EREYVDSTIV SESPLPKRAV SLWSQNSINA HGILLKGIER
IQTRTMATDG YRKLQGLIQH HPDLFADEEQ FAVLLIGLLD ELAEQTPPSK SVLSLGTVSD
HKTQVLFTVK YMFENFKKFF APHYPGTVVA LLEAEKSAEM GGHLIKAIEN FIDDIVNASR
AHYEIIGAVV THLGPAVQNE AGPTEHRMLR KGLDVITHGL TSMKEREWEL PPDQLERLGE
FVRQVMTLPS VALKRRIFAL CIALRELVDN EERFWELVGS KTKGVDGLLF YYRTRQEAQA
A
