STU1_YARLI
ID STU1_YARLI Reviewed; 1597 AA.
AC Q6C882;
DT 23-JAN-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 25-MAY-2022, entry version 84.
DE RecName: Full=Protein STU1;
GN Name=STU1; OrderedLocusNames=YALI0D21912g;
OS Yarrowia lipolytica (strain CLIB 122 / E 150) (Yeast) (Candida lipolytica).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Dipodascaceae; Yarrowia.
OX NCBI_TaxID=284591;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=CLIB 122 / E 150;
RX PubMed=15229592; DOI=10.1038/nature02579;
RA Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA Weissenbach J., Wincker P., Souciet J.-L.;
RT "Genome evolution in yeasts.";
RL Nature 430:35-44(2004).
CC -!- FUNCTION: Microtubule binding protein that promotes the stabilization
CC of dynamic microtubules. Required for mitotic spindle formation (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with microtubules. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}. Nucleus
CC {ECO:0000250}. Cytoplasm, cytoskeleton, spindle {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the CLASP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAG81328.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; CR382130; CAG81328.1; ALT_INIT; Genomic_DNA.
DR RefSeq; XP_503130.1; XM_503130.1.
DR AlphaFoldDB; Q6C882; -.
DR STRING; 4952.CAG81328; -.
DR PRIDE; Q6C882; -.
DR GeneID; 2910152; -.
DR KEGG; yli:YALI0D21912g; -.
DR InParanoid; Q6C882; -.
DR Proteomes; UP000001300; Chromosome D.
DR GO; GO:0005881; C:cytoplasmic microtubule; IBA:GO_Central.
DR GO; GO:0005815; C:microtubule organizing center; IBA:GO_Central.
DR GO; GO:0072686; C:mitotic spindle; IBA:GO_Central.
DR GO; GO:1990023; C:mitotic spindle midzone; IBA:GO_Central.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005876; C:spindle microtubule; IBA:GO_Central.
DR GO; GO:0008017; F:microtubule binding; IBA:GO_Central.
DR GO; GO:0060172; P:astral microtubule depolymerization; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0000226; P:microtubule cytoskeleton organization; IBA:GO_Central.
DR GO; GO:0090307; P:mitotic spindle assembly; IBA:GO_Central.
DR Gene3D; 1.25.10.10; -; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR024395; CLASP_N_dom.
DR InterPro; IPR034085; TOG.
DR Pfam; PF12348; CLASP_N; 1.
DR SMART; SM01349; TOG; 1.
DR SUPFAM; SSF48371; SSF48371; 2.
PE 3: Inferred from homology;
KW Cell cycle; Cell division; Coiled coil; Cytoplasm; Cytoskeleton;
KW Microtubule; Mitosis; Nucleus; Reference proteome.
FT CHAIN 1..1597
FT /note="Protein STU1"
FT /id="PRO_0000272296"
FT REPEAT 1537..1573
FT /note="HEAT"
FT REGION 220..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 519..958
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1005..1154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1307..1332
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 534..552
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 571..641
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 655..670
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 705..726
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 750..784
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 798..823
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 833..866
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 893..907
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 923..950
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1079..1093
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1118..1143
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1597 AA; 174259 MW; 29B9D0CC88900D35 CRC64;
MKSDQLGRVL SDDDLPTKLS IANEFKAFVK KNSVPRDLIH PYFLTLSRAI KSREDPQLTS
VCFSCFCHLF KRVSIQDKQL LDDSATVAVV TDLLIDRLSD RSTGVRATAN KVLLDYWVLV
PQAVAVAMRQ SAVVSSSHVT LGESLKWLQS VFDLSSAFNF SAFVQPVVDM LRYPQLQSSV
CELLKKVYSV SDRRELEECL AATGVNEMLK KSILNGLPGG NSSSAVSDPK TTAPRSLSSQ
KSVASKPAQQ PNSQEPGNEN APSSSLAFLN SLPNFRVDSL APENVYSASD LESKINNMHV
AFADKESEKN WSLREKHVTQ IRKLLRGNAL QDYPSQFAAA YKSVIDGVLK SATSLRTTLS
NQGLLLVKES GQLGGNAFVD PVMDIVFPQI IRLTGQMKKI TSNNAHITVC GLLTSATFST
KLINHVTSAT VEKNAQPRTF AAVWLRILIL SHSQTHKSAM QNHGGLDQIE KAIAKGLQDP
TPSVKENMRV TYWSFAEYWP SEADKIYRKL DTKAKAMLDK VNPSGAKNAP IKKPAPRESL
KEVMRRSRES SVNRDANAPS ATAPPQRAKM GAPQRTSSGL VGRSLSGSNL TDRSNRLSST
STSSRDQQRA VSDSTRPTQM TRPVSGRLSR EPSLTRSSRD QSLTRSSRET VSREPSLTRG
SRELPKQRVD QNRQRVPSIS RDSRYGQRPV GSRESSRQSR ESSLDPSRES SLAPSVHSST
AISRESSLPR DDLPSYDVEM DEDDPFVTQQ LKLSLKQEDA MSQPEETMNE VTTAEATATT
APMKIPKSTP PRESTPPNSS PFVLAKSPAT QGVSTSPATG KSASPPATAE DELSRDLNGE
SKHLKEVDDD NGSMDADERI ESDVVMGDAE ESAANFEPSE VEPAGVQLGL KSPKRETPTS
ALQGNEQAEP ESHDAVADSQ SHGADSADLQ SEPRNVPVSP PTTSDASNVP ILSPRPIHPA
KFELDSDAMI VDEVAPEVNT VIDAQTQAEE TPTEEIPAVV KVGFDAEAKS EPTEQTEAVK
TSDTATEPGE PVDIPNSEQG PSTEPTELAK SAGSVEHVTE AIQEDPFGDA LPAKQENGAK
ASDEIETDHT KSNNTESDGP VSAHDESEPM EICDSDNDAV DNGTNPDTKC QDQQDSTTPP
MDFSSHDLKD ELNTSSPESL TALLSNPDQY KEILDHVPAE LFLLCVILFS ESHVMDAQSV
ISRDTNLALS TASSMVMVCA RDVYPSDSRW SQATVEELKH VTVTCLEWLT KLVNESSEAS
TLLATNKRYR TSLVHLLSTS VELHKQKFGD VTHNSLIHVI ESMDKLSQRP PDKRTSRAFL
EAPSPSPDSS LVEDVTDKLS HVTVKENFKT IRILPPQLAS GQLIFPGSEV TWSKLELERL
ARSPSCSDSN EAILDAVSRD KVSVTQLSTL ASRIPELEDV DLVTATILAY LHISHPPALT
TAALVAIKQV LIKPELKLSM GHVTEIFSTL NHVNSHIDSR SPLAAAIEEL VADLLTHTDS
SEMLEFLLLS RSRDSKTQNK LLLLNTVYHV ITPDLLPSYE TQLLALITEL ISDPDPLVRR
VTVGLVVRVL RVSPEMEGTI SLAIKSKMDL VRYYMGA
