STUA_ASPFN
ID STUA_ASPFN Reviewed; 789 AA.
AC B8NBX4;
DT 13-APR-2016, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 1.
DT 03-AUG-2022, entry version 63.
DE RecName: Full=Cell pattern formation-associated protein stuA {ECO:0000305};
DE AltName: Full=Stunted protein A {ECO:0000250|UniProtKB:P36011};
GN Name=stuA {ECO:0000303|PubMed:26420172}; ORFNames=AFLA_046990;
OS Aspergillus flavus (strain ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357
OS / JCM 12722 / SRRC 167).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC Aspergillus subgen. Circumdati.
OX NCBI_TaxID=332952;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 200026 / FGSC A1120 / IAM 13836 / NRRL 3357 / JCM 12722 / SRRC
RC 167;
RX PubMed=25883274; DOI=10.1128/genomea.00168-15;
RA Nierman W.C., Yu J., Fedorova-Abrams N.D., Losada L., Cleveland T.E.,
RA Bhatnagar D., Bennett J.W., Dean R., Payne G.A.;
RT "Genome sequence of Aspergillus flavus NRRL 3357, a strain that causes
RT aflatoxin contamination of food and feed.";
RL Genome Announc. 3:E0016815-E0016815(2015).
RN [2]
RP INDUCTION.
RX PubMed=26420172; DOI=10.1186/s12866-015-0513-6;
RA Wang H., Lei Y., Yan L., Cheng K., Dai X., Wan L., Guo W., Cheng L.,
RA Liao B.;
RT "Deep sequencing analysis of transcriptomes in Aspergillus flavus in
RT response to resveratrol.";
RL BMC Microbiol. 15:182-182(2015).
CC -!- FUNCTION: Transcription factor that regulates asexual reproduction (By
CC similarity). Binds the StuA-response elements (StRE) with the consensus
CC sequence 5'-(A/T)CGCG(T/A)N(A/C)-3' at the promoters of target genes
CC (By similarity). {ECO:0000250|UniProtKB:P36011}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P36011}.
CC -!- INDUCTION: Expression is down-regulated by resveratrol
CC (PubMed:26420172). {ECO:0000269|PubMed:26420172}.
CC -!- SIMILARITY: Belongs to the EFG1/PHD1/stuA family. {ECO:0000305}.
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DR EMBL; EQ963476; EED52997.1; -; Genomic_DNA.
DR RefSeq; XP_002378161.1; XM_002378120.1.
DR AlphaFoldDB; B8NBX4; -.
DR SMR; B8NBX4; -.
DR STRING; 5059.CADAFLAP00006026; -.
DR EnsemblFungi; EED52997; EED52997; AFLA_046990.
DR VEuPathDB; FungiDB:AFLA_046990; -.
DR eggNOG; ENOG502QW2C; Eukaryota.
DR HOGENOM; CLU_016460_0_0_1; -.
DR OMA; MDVHSSH; -.
DR PHI-base; PHI:7727; -.
DR Proteomes; UP000001875; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0048315; P:conidium formation; IEA:UniProtKB-KW.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR Gene3D; 3.10.260.10; -; 1.
DR InterPro; IPR029790; EFG1/Phd1/StuA.
DR InterPro; IPR036887; HTH_APSES_sf.
DR InterPro; IPR018004; KilA_N/APSES_HTH.
DR InterPro; IPR003163; Tscrpt_reg_HTH_APSES-type.
DR PANTHER; PTHR47792; PTHR47792; 1.
DR SMART; SM01252; KilA-N; 1.
DR SUPFAM; SSF54616; SSF54616; 1.
DR PROSITE; PS51299; HTH_APSES; 1.
PE 2: Evidence at transcript level;
KW Conidiation; DNA-binding; Nucleus; Sporulation; Transcription;
KW Transcription regulation.
FT CHAIN 1..789
FT /note="Cell pattern formation-associated protein stuA"
FT /id="PRO_0000435971"
FT DOMAIN 272..378
FT /note="HTH APSES-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00630"
FT DNA_BIND 306..327
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00630"
FT REGION 50..131
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 205..224
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..459
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 487..543
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 616..789
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 731..758
FT /note="Nuclear localization domain"
FT /evidence="ECO:0000250|UniProtKB:P36011"
FT COMPBIAS 56..96
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 114..131
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 389..407
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 421..436
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 487..533
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 617..720
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 730..760
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 789 AA; 83836 MW; 8F17EC9A2D029B93 CRC64;
MLPCCEPLPL QTEKLELPSI SQVHTRGPVD IPWYNHHAAE RPLLSGDKLP ALSLPTASQP
PISGQSYRTS YEEASASHNA SARTSLSGTA PVINEARSPP QSADLAAGGQ GRLSLDSSAP
QEFSIPQNTV GDSYYTNPTA IGSMNHTQPY MDVHSSHLSS AQPYASQAAT AGGIAHYPQY
HQQPPVLQPA STTYGPASSY QYAYPGGVTS SQPGPQPPTT SVSSQVPAQL LPLPVTSHTV
APAGYGNNTG TPMQGYVYDA TGQVAPPGAK PRVTATLWED EGSLCYQVEA RGVCVARRED
NHMINGTKLL NVAGMTRGRR DGILKSEKVR HVVKIGPMHL KGVWIPFERA LEFANKEKIT
DLLYPLFVHN IGGLLYHPTN QTRTNMVVQE SQQRRLEGPQ ATRASQGPQP PALHHHHSLQ
TPVPSHMSQP HAMTSQSAAR PGLDRAHTFP TPPASASSLM GITNQGSSYE WGNQGMNSGV
PNTQPLSIDT TLSNARSMPT TPATTPPGSN MQGMQAYQSQ SGYDNSKSYY SAAPPSHPQY
APQQPLTQPM APYGQTMPAN TYIKNDMAPP TARTSGGPSD VEQADVKADR YAQTNGHVSN
GAGEPVPEHE PEYVQHDSAG YNTNRGSYTY TTNPSVGSLA GDHSQLASDM SGSPSQQNGS
GRMTPRTSGA PPQWASGYNT PPRSAAVSSL YNSVSETRGA SANGTTDNYS VASNPAPGYS
TGMNGPLGSG KRMREDDDVD QIVRPDSRGA EYESKRRKTL TEATVGGPVG GVPLGLQPMK
AGGVMARRR
