STUA_DOTSN
ID STUA_DOTSN Reviewed; 577 AA.
AC N1PJ97;
DT 13-APR-2016, integrated into UniProtKB/Swiss-Prot.
DT 26-JUN-2013, sequence version 1.
DT 25-MAY-2022, entry version 31.
DE RecName: Full=Cell pattern formation-associated protein stuA {ECO:0000305};
DE AltName: Full=Stunted protein A {ECO:0000250|UniProtKB:P36011};
GN Name=stuA {ECO:0000303|PubMed:22227160}; ORFNames=DOTSEDRAFT_45737;
OS Dothistroma septosporum (strain NZE10 / CBS 128990) (Red band needle blight
OS fungus) (Mycosphaerella pini).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Dothideomycetes;
OC Dothideomycetidae; Mycosphaerellales; Mycosphaerellaceae; Dothistroma.
OX NCBI_TaxID=675120;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NZE10 / CBS 128990;
RX PubMed=23209441; DOI=10.1371/journal.pgen.1003088;
RA de Wit P.J.G.M., van der Burgt A., Oekmen B., Stergiopoulos I.,
RA Abd-Elsalam K.A., Aerts A.L., Bahkali A.H., Beenen H.G., Chettri P.,
RA Cox M.P., Datema E., de Vries R.P., Dhillon B., Ganley A.R.,
RA Griffiths S.A., Guo Y., Hamelin R.C., Henrissat B., Kabir M.S.,
RA Jashni M.K., Kema G., Klaubauf S., Lapidus A., Levasseur A., Lindquist E.,
RA Mehrabi R., Ohm R.A., Owen T.J., Salamov A., Schwelm A., Schijlen E.,
RA Sun H., van den Burg H.A., van Ham R.C.H.J., Zhang S., Goodwin S.B.,
RA Grigoriev I.V., Collemare J., Bradshaw R.E.;
RT "The genomes of the fungal plant pathogens Cladosporium fulvum and
RT Dothistroma septosporum reveal adaptation to different hosts and lifestyles
RT but also signatures of common ancestry.";
RL PLoS Genet. 8:E1003088-E1003088(2012).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NZE10 / CBS 128990;
RX PubMed=23236275; DOI=10.1371/journal.ppat.1003037;
RA Ohm R.A., Feau N., Henrissat B., Schoch C.L., Horwitz B.A., Barry K.W.,
RA Condon B.J., Copeland A.C., Dhillon B., Glaser F., Hesse C.N., Kosti I.,
RA LaButti K., Lindquist E.A., Lucas S., Salamov A.A., Bradshaw R.E.,
RA Ciuffetti L., Hamelin R.C., Kema G.H.J., Lawrence C., Scott J.A.,
RA Spatafora J.W., Turgeon B.G., de Wit P.J.G.M., Zhong S., Goodwin S.B.,
RA Grigoriev I.V.;
RT "Diverse lifestyles and strategies of plant pathogenesis encoded in the
RT genomes of eighteen Dothideomycetes fungi.";
RL PLoS Pathog. 8:E1003037-E1003037(2012).
RN [3]
RP INDUCTION.
RX PubMed=22227160; DOI=10.1016/j.fgb.2011.11.009;
RA Chettri P., Calvo A.M., Cary J.W., Dhingra S., Guo Y., McDougal R.L.,
RA Bradshaw R.E.;
RT "The veA gene of the pine needle pathogen Dothistroma septosporum regulates
RT sporulation and secondary metabolism.";
RL Fungal Genet. Biol. 49:141-151(2012).
CC -!- FUNCTION: Transcription factor that regulates asexual reproduction (By
CC similarity). Binds the StuA-response elements (StRE) with the consensus
CC sequence 5'-(A/T)CGCG(T/A)N(A/C)-3' at the promoters of target genes
CC (By similarity). {ECO:0000250|UniProtKB:P36011}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P36011}.
CC -!- INDUCTION: Expression is positively regulated by veA (PubMed:22227160).
CC {ECO:0000269|PubMed:22227160}.
CC -!- SIMILARITY: Belongs to the EFG1/PHD1/stuA family. {ECO:0000305}.
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DR EMBL; KB446541; EME42179.1; -; Genomic_DNA.
DR AlphaFoldDB; N1PJ97; -.
DR SMR; N1PJ97; -.
DR STRING; 675120.N1PJ97; -.
DR EnsemblFungi; EME42179; EME42179; DOTSEDRAFT_45737.
DR eggNOG; ENOG502QW2C; Eukaryota.
DR HOGENOM; CLU_016460_0_0_1; -.
DR OMA; MDVHSSH; -.
DR OrthoDB; 311987at2759; -.
DR Proteomes; UP000016933; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0048315; P:conidium formation; IEA:UniProtKB-KW.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR Gene3D; 3.10.260.10; -; 1.
DR InterPro; IPR029790; EFG1/Phd1/StuA.
DR InterPro; IPR036887; HTH_APSES_sf.
DR InterPro; IPR018004; KilA_N/APSES_HTH.
DR InterPro; IPR003163; Tscrpt_reg_HTH_APSES-type.
DR PANTHER; PTHR47792; PTHR47792; 1.
DR SMART; SM01252; KilA-N; 1.
DR SUPFAM; SSF54616; SSF54616; 1.
DR PROSITE; PS51299; HTH_APSES; 1.
PE 2: Evidence at transcript level;
KW Conidiation; DNA-binding; Nucleus; Reference proteome; Sporulation;
KW Transcription; Transcription regulation.
FT CHAIN 1..577
FT /note="Cell pattern formation-associated protein stuA"
FT /id="PRO_0000435973"
FT DOMAIN 111..217
FT /note="HTH APSES-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00630"
FT DNA_BIND 145..166
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00630"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 228..487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 518..577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 526..552
FT /note="Nuclear localization domain"
FT /evidence="ECO:0000250|UniProtKB:P36011"
FT COMPBIAS 16..32
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..268
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 293..369
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 446..487
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 525..555
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 577 AA; 62608 MW; 35ACD4C1697E3962 CRC64;
MNQPQPYMDQ HAPAPPPASN MTQYSNYGAP QPLQPATHGY GAPTYPQYGQ YGQSMPPMQA
GHPVSAPMQG QMVNSLPLPT MSAPQQSGGT QQFQQSFDTT GQIAPHGMKP RVTATLWEDE
GSLCFQVEAN GVCVARREDN HMINGTKLLN VAGMTRGRRD GILKSEKTRH VVKIGPMHLK
GVWIPFDRAL DFANKEKITE LLYPLFVHNI GALLYHPTNQ ARQSIGNATM AARRPESSQE
YMRTPQGTQA PALTHHHSMS NPINASMPPQ PHSIAPHPAS GRPQLDRAHT FPTPPASASS
MPMTNGNMPN SYEYGSAGAV NSASTPPSNS QGMPQYQTSQ PPYTQSYSTP GSYSQPQYTH
QQPGVQRFGN IHSSPDGVKT EMGPPARAGA ENDHPDHKVG GYGGQQDAEG EHEGEYTHTS
ASYGARRLSY NYKPNPAPGP LHQDSSHVSP EMTHSPHQNG SGRATPRTTN PYTGYNNTPQ
RQNQLPSSNL NYVMSSDARA GAPNGQEYAQ QAYQPAPQYP AMNGIKRGRE DDDQVDPYGR
PSSALGEHKR QRTDPGAMSA RPISQPHSIK AGGAVRR
