STUA_GIBM7
ID STUA_GIBM7 Reviewed; 549 AA.
AC W7LYY0;
DT 13-APR-2016, integrated into UniProtKB/Swiss-Prot.
DT 16-APR-2014, sequence version 1.
DT 25-MAY-2022, entry version 33.
DE RecName: Full=Cell pattern formation-associated protein StuA {ECO:0000305};
DE AltName: Full=Stunted protein A {ECO:0000250|UniProtKB:P36011};
GN Name=StuA {ECO:0000303|PubMed:24161731}; ORFNames=FVEG_02853;
OS Gibberella moniliformis (strain M3125 / FGSC 7600) (Maize ear and stalk rot
OS fungus) (Fusarium verticillioides).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Hypocreomycetidae; Hypocreales; Nectriaceae; Fusarium;
OC Fusarium fujikuroi species complex.
OX NCBI_TaxID=334819;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=M3125 / FGSC 7600;
RX PubMed=20237561; DOI=10.1038/nature08850;
RA Ma L.-J., van der Does H.C., Borkovich K.A., Coleman J.J., Daboussi M.-J.,
RA Di Pietro A., Dufresne M., Freitag M., Grabherr M., Henrissat B.,
RA Houterman P.M., Kang S., Shim W.-B., Woloshuk C., Xie X., Xu J.-R.,
RA Antoniw J., Baker S.E., Bluhm B.H., Breakspear A., Brown D.W.,
RA Butchko R.A.E., Chapman S., Coulson R., Coutinho P.M., Danchin E.G.J.,
RA Diener A., Gale L.R., Gardiner D.M., Goff S., Hammond-Kosack K.E.,
RA Hilburn K., Hua-Van A., Jonkers W., Kazan K., Kodira C.D., Koehrsen M.,
RA Kumar L., Lee Y.-H., Li L., Manners J.M., Miranda-Saavedra D.,
RA Mukherjee M., Park G., Park J., Park S.-Y., Proctor R.H., Regev A.,
RA Ruiz-Roldan M.C., Sain D., Sakthikumar S., Sykes S., Schwartz D.C.,
RA Turgeon B.G., Wapinski I., Yoder O., Young S., Zeng Q., Zhou S.,
RA Galagan J., Cuomo C.A., Kistler H.C., Rep M.;
RT "Comparative genomics reveals mobile pathogenicity chromosomes in
RT Fusarium.";
RL Nature 464:367-373(2010).
RN [2]
RP INDUCTION, DISRUPTION PHENOTYPE, AND FUNCTION.
RX PubMed=24161731; DOI=10.1016/j.fgb.2013.10.008;
RA Malapi-Wight M., Kim J.E., Shim W.B.;
RT "The N-terminus region of the putative C2H2 transcription factor Ada1
RT harbors a species-specific activation motif that regulates asexual
RT reproduction in Fusarium verticillioides.";
RL Fungal Genet. Biol. 62:25-33(2014).
CC -!- FUNCTION: Transcription factor that regulates asexual reproduction
CC (PubMed:24161731). Binds the StuA-response elements (StRE) with the
CC consensus sequence 5'-(A/T)CGCG(T/A)N(A/C)-3' at the promoters of
CC target genes (By similarity). {ECO:0000250|UniProtKB:P36011,
CC ECO:0000269|PubMed:24161731}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P36011}.
CC -!- INDUCTION: Expression is regulated by the upstream regulator ada1
CC (PubMed:24161731). {ECO:0000269|PubMed:24161731}.
CC -!- DISRUPTION PHENOTYPE: Results in near absence of conidia production
CC (PubMed:24161731). {ECO:0000269|PubMed:24161731}.
CC -!- SIMILARITY: Belongs to the EFG1/PHD1/stuA family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DS022244; EWG40475.1; -; Genomic_DNA.
DR EMBL; DS022244; EWG40476.1; -; Genomic_DNA.
DR RefSeq; XP_018746666.1; XM_018890367.1.
DR RefSeq; XP_018746667.1; XM_018890368.1.
DR AlphaFoldDB; W7LYY0; -.
DR SMR; W7LYY0; -.
DR STRING; 117187.FVEG_02853T0; -.
DR EnsemblFungi; FVEG_02853T0; FVEG_02853T0; FVEG_02853.
DR GeneID; 30061033; -.
DR KEGG; fvr:FVEG_02853; -.
DR VEuPathDB; FungiDB:FVEG_02853; -.
DR eggNOG; ENOG502QW2C; Eukaryota.
DR HOGENOM; CLU_016460_0_0_1; -.
DR OMA; HNPPGMK; -.
DR OrthoDB; 311987at2759; -.
DR Proteomes; UP000009096; Chromosome 5.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0048315; P:conidium formation; IEA:UniProtKB-KW.
DR GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR Gene3D; 3.10.260.10; -; 1.
DR InterPro; IPR029790; EFG1/Phd1/StuA.
DR InterPro; IPR036887; HTH_APSES_sf.
DR InterPro; IPR018004; KilA_N/APSES_HTH.
DR InterPro; IPR003163; Tscrpt_reg_HTH_APSES-type.
DR PANTHER; PTHR47792; PTHR47792; 1.
DR SMART; SM01252; KilA-N; 1.
DR SUPFAM; SSF54616; SSF54616; 1.
DR PROSITE; PS51299; HTH_APSES; 1.
PE 2: Evidence at transcript level;
KW Conidiation; DNA-binding; Nucleus; Phosphoprotein; Reference proteome;
KW Sporulation; Transcription; Transcription regulation.
FT CHAIN 1..549
FT /note="Cell pattern formation-associated protein StuA"
FT /id="PRO_0000435976"
FT DOMAIN 86..192
FT /note="HTH APSES-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00630"
FT DNA_BIND 120..141
FT /note="H-T-H motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00630"
FT REGION 205..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 246..288
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 332..466
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 514..549
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 516..545
FT /note="Nuclear localization domain"
FT /evidence="ECO:0000250|UniProtKB:P36011"
FT COMPBIAS 246..262
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..414
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 444..458
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 549 AA; 59565 MW; 59C1EFC3213E3584 CRC64;
MNQGHPQPDM YYSPHYSTPQ YGYGYSTNGA PTTAVSTPMP APQNVLPVPS ALSNQGAMQQ
PGYSNSSNNG AFDTTGQHNP PGMKPRVTAT LWEDEGSLCF QVEARGICVA RREDNHMING
TKLLNVAGMT RGRRDGILKS EKVRHVVKIG PMHLKGVWIP YDRALDFANK EKITELLFPL
FVHNIGALLY HPSNSNRTSQ VMAAAERRKH EGLGGQRPPA PNALPSIGQH HPMMPGLPTG
GYVPQSLANG PQSLASTPQP LANGSQPPMP NGGGMLKRGR EEEEDLHRPV SNGHDPMSNM
HAMSNGYPQQ PPLANVHQPP MQNGGDMLKR GREEDDEVHR SAHNAHDTMN NMPGSMPGMS
NAYAQPLPNV HHQPLANGDG GMLKRGRDED DDHRSSPNGH DSAGNFEAKR RKTITSNDSM
VSPGGFYTLH NGYGQPGVMN GMSPYKRRDD EAETPRPGPN VHDHLNNFDL KRHKTMETSV
PAPQYDAMNR PHSSIGTSPS YAPAPVYDNL ARPASTVAAS PSYPSAPVYD TAARPPSAIS
APRRQQSFG
