ID   STUA_NEUCR              Reviewed;         643 AA.
AC   Q1K6U0;
DT   13-APR-2016, integrated into UniProtKB/Swiss-Prot.
DT   28-JUN-2011, sequence version 1.
DT   25-MAY-2022, entry version 47.
DE   RecName: Full=Cell pattern formation-associated protein asm-1 {ECO:0000305};
DE   AltName: Full=Ascospore maturation protein 1 {ECO:0000303|PubMed:8913744};
GN   Name=Asm-1 {ECO:0000303|PubMed:8913744}; ORFNames=NCU01414;
OS   Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 /
OS   FGSC 987).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Sordariales; Sordariaceae; Neurospora.
OX   NCBI_TaxID=367110;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987;
RX   PubMed=12712197; DOI=10.1038/nature01554;
RA   Galagan J.E., Calvo S.E., Borkovich K.A., Selker E.U., Read N.D.,
RA   Jaffe D.B., FitzHugh W., Ma L.-J., Smirnov S., Purcell S., Rehman B.,
RA   Elkins T., Engels R., Wang S., Nielsen C.B., Butler J., Endrizzi M.,
RA   Qui D., Ianakiev P., Bell-Pedersen D., Nelson M.A., Werner-Washburne M.,
RA   Selitrennikoff C.P., Kinsey J.A., Braun E.L., Zelter A., Schulte U.,
RA   Kothe G.O., Jedd G., Mewes H.-W., Staben C., Marcotte E., Greenberg D.,
RA   Roy A., Foley K., Naylor J., Stange-Thomann N., Barrett R., Gnerre S.,
RA   Kamal M., Kamvysselis M., Mauceli E.W., Bielke C., Rudd S., Frishman D.,
RA   Krystofova S., Rasmussen C., Metzenberg R.L., Perkins D.D., Kroken S.,
RA   Cogoni C., Macino G., Catcheside D.E.A., Li W., Pratt R.J., Osmani S.A.,
RA   DeSouza C.P.C., Glass N.L., Orbach M.J., Berglund J.A., Voelker R.,
RA   Yarden O., Plamann M., Seiler S., Dunlap J.C., Radford A., Aramayo R.,
RA   Natvig D.O., Alex L.A., Mannhaupt G., Ebbole D.J., Freitag M., Paulsen I.,
RA   Sachs M.S., Lander E.S., Nusbaum C., Birren B.W.;
RT   "The genome sequence of the filamentous fungus Neurospora crassa.";
RL   Nature 422:859-868(2003).
RN   [2]
RP   INDUCTION, DISRUPTION PHENOTYPE, FUNCTION, AND SUBCELLULAR LOCATION.
RX   PubMed=8913744; DOI=10.1093/genetics/144.3.991;
RA   Aramayo R., Peleg Y., Addison R., Metzenberg R.;
RT   "Asm-1+, a Neurospora crassa gene related to transcriptional regulators of
RT   fungal development.";
RL   Genetics 144:991-1003(1996).
RN   [3]
RP   FUNCTION.
RX   PubMed=25550299; DOI=10.3852/14-079;
RA   Chung D., Upadhyay S., Bomer B., Wilkinson H.H., Ebbole D.J., Shaw B.D.;
RT   "Neurospora crassa ASM-1 complements the conidiation defect in a stuA
RT   mutant of Aspergillus nidulans.";
RL   Mycologia 107:298-306(2015).
CC   -!- FUNCTION: Transcription factor that regulates asexual reproduction
CC       (PubMed:8913744, PubMed:25550299). Binds the StuA-response elements
CC       (StRE) with the consensus sequence 5'-(A/T)CGCG(T/A)N(A/C)-3' at the
CC       promoters of target genes (By similarity). Required for rapid conidial
CC       germination, normal vegetative morphology, and protoperithecium
CC       formation (PubMed:8913744). {ECO:0000250|UniProtKB:P36011,
CC       ECO:0000269|PubMed:25550299, ECO:0000269|PubMed:8913744}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:8913744}.
CC   -!- INDUCTION: Constitutively expressed during the mycelial, conidial, and
CC       perithecial stages of the life cycle (PubMed:8913744).
CC       {ECO:0000269|PubMed:8913744}.
CC   -!- DISRUPTION PHENOTYPE: Destroys the ability to make protoperithecia
CC       (female organs), but does not affect male-specific functions
CC       (PubMed:8913744). {ECO:0000269|PubMed:8913744}.
CC   -!- SIMILARITY: Belongs to the EFG1/PHD1/stuA family. {ECO:0000305}.
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DR   EMBL; CM002240; EAA31601.1; -; Genomic_DNA.
DR   RefSeq; XP_960837.1; XM_955744.3.
DR   AlphaFoldDB; Q1K6U0; -.
DR   SMR; Q1K6U0; -.
DR   STRING; 5141.EFNCRP00000004057; -.
DR   EnsemblFungi; EAA31601; EAA31601; NCU01414.
DR   GeneID; 3876984; -.
DR   KEGG; ncr:NCU01414; -.
DR   VEuPathDB; FungiDB:NCU01414; -.
DR   HOGENOM; CLU_016460_0_0_1; -.
DR   InParanoid; Q1K6U0; -.
DR   OMA; MDVHSSH; -.
DR   Proteomes; UP000001805; Chromosome 2, Linkage Group V.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0048315; P:conidium formation; IEA:UniProtKB-KW.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.260.10; -; 1.
DR   InterPro; IPR029790; EFG1/Phd1/StuA.
DR   InterPro; IPR036887; HTH_APSES_sf.
DR   InterPro; IPR018004; KilA_N/APSES_HTH.
DR   InterPro; IPR003163; Tscrpt_reg_HTH_APSES-type.
DR   PANTHER; PTHR47792; PTHR47792; 1.
DR   SMART; SM01252; KilA-N; 1.
DR   SUPFAM; SSF54616; SSF54616; 1.
DR   PROSITE; PS51299; HTH_APSES; 1.
PE   2: Evidence at transcript level;
KW   Conidiation; DNA-binding; Nucleus; Reference proteome; Sporulation;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..643
FT                   /note="Cell pattern formation-associated protein asm-1"
FT                   /id="PRO_0000435980"
FT   DOMAIN          116..222
FT                   /note="HTH APSES-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00630"
FT   DNA_BIND        150..171
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00630"
FT   REGION          1..37
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          229..627
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          583..612
FT                   /note="Nuclear localization domain"
FT                   /evidence="ECO:0000250|UniProtKB:P36011"
FT   COMPBIAS        289..443
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        467..483
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        508..578
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   643 AA;  68449 MW;  56B4C1AF11AE44D7 CRC64;
     MNPNTPADVY YGQMSQGSSM PVTTVPSHSH YASQQPPPLL QPGSTYAHQY GTPQYGYANA
     LSSPASIPPS LPPSMNSMAG QSVLPLPGSG SMNPAVYASG GFDTTGQVAP PGMKPRVTAT
     LWEDEGSLCF QVEARGICVA RREDNAMING TKLLNVAGMT RGRRDGILKS EKVRHVVKIG
     PMHLKGVWIP FERALDFANK EKITELLYPL FVHNIGALLY HPTNQSRTSQ VMAAAEQRRK
     DSHGQLRGPP GLPSLQQHHH HHSMLPGPPS LPSHPSMGRP ALDRAHTFPT PPTSASSVMG
     PMGNSDGYQW SQQSMSGTQG NSSLSLDTSL GSNARSMPST PATTPPGSTI QSMQNYPPVS
     QSYESSRQMY QGQSAQQAQY QSQQHYSSQP QHQERPVYSQ SSYIKNDMGP PSGRPTGQSN
     DASDSKPPTG MIHQGQGQSD PGTHAGSEED DDANNEAEYT HDSGGYDANR GSYNYNTQAV
     NSLPHDHGLA PEIGGSPHQA GSGRATPRTA AAPSSYYSAQ GYHTPPRGQP SSSLYNVMSN
     ERTGSNGTQG NEMYAGQADM PSSLPNGYSA QPSVMNGSSG GLKRGRDDDD DGGRPTTSAP
     NLGPGMDMKR RKTMMDGGSL PSPTYTATIA QAAPSAIAAH RRR