ID   STUA_PENRW              Reviewed;         818 AA.
AC   B6H2G9;
DT   13-APR-2016, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Cell pattern formation-associated protein stuA {ECO:0000305};
DE   AltName: Full=Stunted protein A {ECO:0000250|UniProtKB:P36011};
GN   Name=stuA {ECO:0000303|PubMed:21148688}; ORFNames=Pc13g04920;
OS   Penicillium rubens (strain ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin
OS   54-1255) (Penicillium chrysogenum).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium;
OC   Penicillium chrysogenum species complex.
OX   NCBI_TaxID=500485;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 28089 / DSM 1075 / NRRL 1951 / Wisconsin 54-1255;
RX   PubMed=18820685; DOI=10.1038/nbt.1498;
RA   van den Berg M.A., Albang R., Albermann K., Badger J.H., Daran J.-M.,
RA   Driessen A.J.M., Garcia-Estrada C., Fedorova N.D., Harris D.M.,
RA   Heijne W.H.M., Joardar V.S., Kiel J.A.K.W., Kovalchuk A., Martin J.F.,
RA   Nierman W.C., Nijland J.G., Pronk J.T., Roubos J.A., van der Klei I.J.,
RA   van Peij N.N.M.E., Veenhuis M., von Doehren H., Wagner C., Wortman J.R.,
RA   Bovenberg R.A.L.;
RT   "Genome sequencing and analysis of the filamentous fungus Penicillium
RT   chrysogenum.";
RL   Nat. Biotechnol. 26:1161-1168(2008).
RN   [2]
RP   FUNCTION, AND DISRUPTION PHENOTYPE.
RX   PubMed=21148688; DOI=10.1128/aem.01557-10;
RA   Sigl C., Haas H., Specht T., Pfaller K., Kuernsteiner H., Zadra I.;
RT   "Among developmental regulators, StuA but not BrlA is essential for
RT   penicillin V production in Penicillium chrysogenum.";
RL   Appl. Environ. Microbiol. 77:972-982(2011).
RN   [3]
RP   SUBCELLULAR LOCATION.
RX   PubMed=11810244; DOI=10.1007/s00438-001-0591-z;
RA   Banuelos O., Casqueiro J., Steidl S., Gutierrez S., Brakhage A.,
RA   Martin J.F.;
RT   "Subcellular localization of the homocitrate synthase in Penicillium
RT   chrysogenum.";
RL   Mol. Genet. Genomics 266:711-719(2002).
CC   -!- FUNCTION: Transcription factor that regulates asexual reproduction
CC       (PubMed:21148688). Binds the StuA-response elements (StRE) with the
CC       consensus sequence 5'-(A/T)CGCG(T/A)N(A/C)-3' at the promoters of
CC       target genes (By similarity). Controls the expression of the penicillin
CC       gene cluster (PubMed:21148688). {ECO:0000250|UniProtKB:P36011,
CC       ECO:0000269|PubMed:21148688}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:11810244}.
CC   -!- DISRUPTION PHENOTYPE: Blocks conidiation and causes aberrant hyphal
CC       morphology (PubMed:21148688). Decreases expression of developmental
CC       regulators brlA and abaA (PubMed:21148688).
CC       {ECO:0000269|PubMed:21148688}.
CC   -!- SIMILARITY: Belongs to the EFG1/PHD1/stuA family. {ECO:0000305}.
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DR   EMBL; AM920428; CAP91561.1; -; Genomic_DNA.
DR   RefSeq; XP_002558927.1; XM_002558881.1.
DR   AlphaFoldDB; B6H2G9; -.
DR   SMR; B6H2G9; -.
DR   STRING; 1108849.XP_002558927.1; -.
DR   EnsemblFungi; CAP91561; CAP91561; PCH_Pc13g04920.
DR   GeneID; 8312363; -.
DR   KEGG; pcs:Pc13g04920; -.
DR   VEuPathDB; FungiDB:PCH_Pc13g04920; -.
DR   eggNOG; ENOG502QW2C; Eukaryota.
DR   HOGENOM; CLU_016460_0_0_1; -.
DR   OMA; MDVHSSH; -.
DR   OrthoDB; 311987at2759; -.
DR   BioCyc; PCHR:PC13G04920-MON; -.
DR   Proteomes; UP000000724; Contig Pc00c13.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0048315; P:conidium formation; IEA:UniProtKB-KW.
DR   GO; GO:0030435; P:sporulation resulting in formation of a cellular spore; IEA:UniProtKB-KW.
DR   Gene3D; 3.10.260.10; -; 1.
DR   InterPro; IPR029790; EFG1/Phd1/StuA.
DR   InterPro; IPR036887; HTH_APSES_sf.
DR   InterPro; IPR018004; KilA_N/APSES_HTH.
DR   InterPro; IPR003163; Tscrpt_reg_HTH_APSES-type.
DR   PANTHER; PTHR47792; PTHR47792; 1.
DR   SMART; SM01252; KilA-N; 1.
DR   SUPFAM; SSF54616; SSF54616; 1.
DR   PROSITE; PS51299; HTH_APSES; 1.
PE   3: Inferred from homology;
KW   Conidiation; DNA-binding; Nucleus; Reference proteome; Sporulation;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..818
FT                   /note="Cell pattern formation-associated protein stuA"
FT                   /id="PRO_0000435981"
FT   DOMAIN          320..426
FT                   /note="HTH APSES-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00630"
FT   DNA_BIND        354..375
FT                   /note="H-T-H motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00630"
FT   REGION          100..164
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          437..571
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          583..818
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          765..788
FT                   /note="Nuclear localization domain"
FT                   /evidence="ECO:0000250|UniProtKB:P36011"
FT   COMPBIAS        456..486
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        500..571
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        650..698
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        716..762
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        764..789
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   818 AA;  87533 MW;  793FB1910A4FD45A CRC64;
     MCSTIVNDLD DYCASLNSSF SKSLYCASHD GRHLRRPLLA SSLYSKPFIR ATEKLELPSI
     SQVHTRGPAD IPWYNPHAAE RPLLPGDKLP ALSLPTATQG LSRTAYPDPS VTNSTNSSAR
     TSLSSASVPV NEPRSPPSSA DLSGTQGRLS LDSSAPTEYS LPPSVNEGYY PSPTSLGSMN
     QTQPYMDVHS HMSSAQSYAP QGATAGAMSQ YQYHGQPPVM QPASSYAPAA YPQYGYPTGV
     TSPPTGHPPS SMGGQMPAQL LPLPGKLQSQ NVIEDYSDRY QVSNHAVAPP SGYGNSTGAP
     LQGFVFDGTG QVAPPGAKPR VTATLWEDEG SLCYQVEAKG VCVARREDNH MINGTKLLNV
     AGMTRGRRDG ILKSEKLRHV VKIGPMHLKG VWIPFERALE FANKEKITDL LYPLFVHNIG
     GLLYHPANQT RTNMVVQESQ QRRLEGPPPG PQRTPSGSQQ GPIHHHHPSL QTPMSSHMSQ
     GPMNGQPGSR PGLERANTFP TPPASASSMM NQGSSYEWGG QVPHTQPLSI DTTLSNQRSM
     PTTPATTPPG NNMQGLPAYQ GQGYDSSKPY YSAAPQTHAQ YAPHTPLTQS GMSSYGQPLA
     GGYMKSEMAP PNPRPGVSEP ETSERDSNRY SQSNGPGETV AEHDQEYMQD HNAGYNSNRG
     SYTYTTNPSV SSLTGEHSQL TPEMTSSPSQ QNGSGRMTPR TGAGPPPHWA SGYNTPPRPA
     ATTLYNAVSD TRGTPANGAS DPYSMASTTA PVYPTGNGSL SAGSKRMRED DDIRAESTAE
     YETSKRRKTI TDATLGGPVG GPPILQPMKP SGVMARHR