STUM_HUMAN
ID STUM_HUMAN Reviewed; 141 AA.
AC Q69YW2; A6NGL2;
DT 20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 13-SEP-2004, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Protein stum homolog;
GN Name=STUM {ECO:0000312|HGNC:HGNC:30491};
GN Synonyms=C1orf95 {ECO:0000312|HGNC:HGNC:30491};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Amygdala;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
CC -!- INTERACTION:
CC Q69YW2; Q6UX98: ZDHHC24; NbExp=3; IntAct=EBI-22730169, EBI-10254561;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the SPEC3 family. Stum subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL137507; CAH10697.1; -; mRNA.
DR EMBL; AL359704; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL357122; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL365444; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS31044.1; -.
DR RefSeq; NP_001003665.1; NM_001003665.3.
DR AlphaFoldDB; Q69YW2; -.
DR BioGRID; 131953; 19.
DR IntAct; Q69YW2; 1.
DR STRING; 9606.ENSP00000355752; -.
DR PhosphoSitePlus; Q69YW2; -.
DR SwissPalm; Q69YW2; -.
DR BioMuta; STUM; -.
DR DMDM; 74748348; -.
DR jPOST; Q69YW2; -.
DR MassIVE; Q69YW2; -.
DR PaxDb; Q69YW2; -.
DR PeptideAtlas; Q69YW2; -.
DR PRIDE; Q69YW2; -.
DR ProteomicsDB; 66172; -.
DR Antibodypedia; 34651; 104 antibodies from 19 providers.
DR DNASU; 375057; -.
DR Ensembl; ENST00000366788.8; ENSP00000355752.3; ENSG00000203685.11.
DR GeneID; 375057; -.
DR KEGG; hsa:375057; -.
DR MANE-Select; ENST00000366788.8; ENSP00000355752.3; NM_001003665.4; NP_001003665.1.
DR UCSC; uc057pyu.1; human.
DR CTD; 375057; -.
DR DisGeNET; 375057; -.
DR GeneCards; STUM; -.
DR HGNC; HGNC:30491; STUM.
DR HPA; ENSG00000203685; Tissue enriched (brain).
DR neXtProt; NX_Q69YW2; -.
DR OpenTargets; ENSG00000203685; -.
DR PharmGKB; PA142672479; -.
DR VEuPathDB; HostDB:ENSG00000203685; -.
DR eggNOG; ENOG502S270; Eukaryota.
DR GeneTree; ENSGT00390000008003; -.
DR HOGENOM; CLU_139845_0_0_1; -.
DR InParanoid; Q69YW2; -.
DR OrthoDB; 1578576at2759; -.
DR PhylomeDB; Q69YW2; -.
DR TreeFam; TF313260; -.
DR PathwayCommons; Q69YW2; -.
DR SignaLink; Q69YW2; -.
DR BioGRID-ORCS; 375057; 6 hits in 1048 CRISPR screens.
DR ChiTaRS; STUM; human.
DR GenomeRNAi; 375057; -.
DR Pharos; Q69YW2; Tdark.
DR PRO; PR:Q69YW2; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q69YW2; protein.
DR Bgee; ENSG00000203685; Expressed in lateral nuclear group of thalamus and 151 other tissues.
DR ExpressionAtlas; Q69YW2; baseline and differential.
DR Genevisible; Q69YW2; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR InterPro; IPR026673; SPEC3/Stum.
DR PANTHER; PTHR21676; PTHR21676; 1.
DR Pfam; PF15795; Spec3; 1.
PE 1: Evidence at protein level;
KW Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..141
FT /note="Protein stum homolog"
FT /id="PRO_0000278635"
FT TRANSMEM 51..71
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 87..107
FT /note="Helical"
FT /evidence="ECO:0000255"
FT MOD_RES 26
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q0VBF8"
SQ SEQUENCE 141 AA; 15007 MW; FA920DAA781620C5 CRC64;
MEPSHKDAET AAAAAAVAAA DPRGASSSSG VVVQVREKKG PLRAAIPYMP FPVAVICLFL
NTFVPGLGTF VSAFTVLCGA RTDLPDRHVC CVFWLNIAAA LIQILTAIVM VGWIMSIFWG
MDMVILAISQ GYKEQGIPQQ L
