ID   STUM_MOUSE              Reviewed;         141 AA.
AC   Q0VBF8;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Protein stum homolog;
GN   Name=Stum {ECO:0000303|PubMed:24626929};
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=24626929; DOI=10.1126/science.1247761;
RA   Desai B.S., Chadha A., Cook B.;
RT   "The stum gene is essential for mechanical sensing in proprioceptive
RT   neurons.";
RL   Science 343:1256-1259(2014).
RN   [3]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-26, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC   TISSUE=Brain;
RX   PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA   Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA   Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT   "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL   Cell 143:1174-1189(2010).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- MISCELLANEOUS: Able to rescue the walking impairment phenotype when
CC       transfected in mutant flies lacking the stum protein (AC Q9W2E1).
CC       {ECO:0000305|PubMed:24626929}.
CC   -!- SIMILARITY: Belongs to the SPEC3 family. Stum subfamily. {ECO:0000305}.
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DR   EMBL; BC120654; AAI20655.1; -; mRNA.
DR   EMBL; BC120656; AAI20657.1; -; mRNA.
DR   CCDS; CCDS48467.1; -.
DR   RefSeq; NP_001074696.1; NM_001081227.2.
DR   AlphaFoldDB; Q0VBF8; -.
DR   STRING; 10090.ENSMUSP00000119782; -.
DR   iPTMnet; Q0VBF8; -.
DR   PhosphoSitePlus; Q0VBF8; -.
DR   SwissPalm; Q0VBF8; -.
DR   MaxQB; Q0VBF8; -.
DR   PaxDb; Q0VBF8; -.
DR   PRIDE; Q0VBF8; -.
DR   ProteomicsDB; 254763; -.
DR   Antibodypedia; 34651; 104 antibodies from 19 providers.
DR   Ensembl; ENSMUST00000136521; ENSMUSP00000119782; ENSMUSG00000053963.
DR   GeneID; 381310; -.
DR   KEGG; mmu:381310; -.
DR   UCSC; uc007dwh.2; mouse.
DR   CTD; 375057; -.
DR   MGI; MGI:2138735; Stum.
DR   VEuPathDB; HostDB:ENSMUSG00000053963; -.
DR   eggNOG; ENOG502S270; Eukaryota.
DR   GeneTree; ENSGT00390000008003; -.
DR   HOGENOM; CLU_139845_0_0_1; -.
DR   InParanoid; Q0VBF8; -.
DR   OrthoDB; 1578576at2759; -.
DR   PhylomeDB; Q0VBF8; -.
DR   TreeFam; TF313260; -.
DR   BioGRID-ORCS; 381310; 3 hits in 72 CRISPR screens.
DR   PRO; PR:Q0VBF8; -.
DR   Proteomes; UP000000589; Chromosome 1.
DR   RNAct; Q0VBF8; protein.
DR   Bgee; ENSMUSG00000053963; Expressed in medial dorsal nucleus of thalamus and 116 other tissues.
DR   ExpressionAtlas; Q0VBF8; baseline and differential.
DR   Genevisible; Q0VBF8; MM.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   InterPro; IPR026673; SPEC3/Stum.
DR   PANTHER; PTHR21676; PTHR21676; 1.
DR   Pfam; PF15795; Spec3; 1.
PE   1: Evidence at protein level;
KW   Membrane; Phosphoprotein; Reference proteome; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..141
FT                   /note="Protein stum homolog"
FT                   /id="PRO_0000278636"
FT   TRANSMEM        51..71
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        87..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   MOD_RES         26
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:21183079"
SQ   SEQUENCE   141 AA;  15005 MW;  204CC262DB0598E7 CRC64;
     MEPLHKDAET AAAAAAVAAA DPRGASSSSG VVVQVREKKG PLRAAIPYMP FPVAVICLFL
     NTFVPGLGTF VSAFTVLCGA RTDLPDRHVC CVFWLNIAAA LIQVLTAIVM VGWIMSIFWG
     MDMVILAISQ GYKDQGIPQQ L