STX11_HUMAN
ID STX11_HUMAN Reviewed; 287 AA.
AC O75558; E1P598; O75378; O95148; Q5TCL6;
DT 15-JUL-1999, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 186.
DE RecName: Full=Syntaxin-11;
GN Name=STX11;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9571206; DOI=10.1006/bbrc.1998.8490;
RA Tang B.L., Low D.Y.H., Hong W.;
RT "Syntaxin 11: a member of the syntaxin family without a carboxyl terminal
RT transmembrane domain.";
RL Biochem. Biophys. Res. Commun. 245:627-632(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9553086; DOI=10.1074/jbc.273.17.10317;
RA Advani R.J., Bae H.-R., Bock J.B., Chao D.S., Doung Y.-C., Prekeris R.,
RA Yoo J.-S., Scheller R.H.;
RT "Seven novel mammalian SNARE proteins localize to distinct membrane
RT compartments.";
RL J. Biol. Chem. 273:10317-10324(1998).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Placenta;
RX PubMed=10036234; DOI=10.1242/jcs.112.6.845;
RA Valdez A.C., Cabaniols J.-P., Brown M.J., Roche P.A.;
RT "Syntaxin 11 is associated with SNAP-23 on late endosomes and the trans-
RT Golgi network.";
RL J. Cell Sci. 112:845-854(1999).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [7]
RP INVOLVEMENT IN FHL4.
RX PubMed=15703195; DOI=10.1093/hmg/ddi076;
RA zur Stadt U., Schmidt S., Kasper B., Beutel K., Diler A.S., Henter J.-I.,
RA Kabisch H., Schneppenheim R., Nuernberg P., Janka G., Hennies H.C.;
RT "Linkage of familial hemophagocytic lymphohistiocytosis (FHL) type-4 to
RT chromosome 6q24 and identification of mutations in syntaxin 11.";
RL Hum. Mol. Genet. 14:827-834(2005).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25944712; DOI=10.1002/pmic.201400617;
RA Vaca Jacome A.S., Rabilloud T., Schaeffer-Reiss C., Rompais M., Ayoub D.,
RA Lane L., Bairoch A., Van Dorsselaer A., Carapito C.;
RT "N-terminome analysis of the human mitochondrial proteome.";
RL Proteomics 15:2519-2524(2015).
CC -!- FUNCTION: SNARE that acts to regulate protein transport between late
CC endosomes and the trans-Golgi network.
CC -!- SUBUNIT: Interacts with the SNARE proteins SNAP-23 and VAMP.
CC -!- INTERACTION:
CC O75558; P01023: A2M; NbExp=3; IntAct=EBI-714135, EBI-640741;
CC O75558; Q86V38: ATN1; NbExp=3; IntAct=EBI-714135, EBI-11954292;
CC O75558; A0A0S2Z4M1: AXIN1; NbExp=3; IntAct=EBI-714135, EBI-16429430;
CC O75558; O15169: AXIN1; NbExp=3; IntAct=EBI-714135, EBI-710484;
CC O75558; Q9Y2T1: AXIN2; NbExp=3; IntAct=EBI-714135, EBI-4400025;
CC O75558; Q9Y5Z0: BACE2; NbExp=3; IntAct=EBI-714135, EBI-11282723;
CC O75558; Q9UL45: BLOC1S6; NbExp=6; IntAct=EBI-714135, EBI-465781;
CC O75558; Q13895: BYSL; NbExp=8; IntAct=EBI-714135, EBI-358049;
CC O75558; Q9NX04: C1orf109; NbExp=6; IntAct=EBI-714135, EBI-8643161;
CC O75558; Q9H257: CARD9; NbExp=3; IntAct=EBI-714135, EBI-751319;
CC O75558; Q6UXH8: CCBE1; NbExp=3; IntAct=EBI-714135, EBI-3923278;
CC O75558; Q96HB5: CCDC120; NbExp=3; IntAct=EBI-714135, EBI-744556;
CC O75558; Q86Z20: CCDC125; NbExp=3; IntAct=EBI-714135, EBI-11977221;
CC O75558; Q52MB2: CCDC184; NbExp=6; IntAct=EBI-714135, EBI-10179526;
CC O75558; A0A1B0GWI1: CCDC196; NbExp=3; IntAct=EBI-714135, EBI-10181422;
CC O75558; Q8TD31-3: CCHCR1; NbExp=3; IntAct=EBI-714135, EBI-10175300;
CC O75558; Q96GN5: CDCA7L; NbExp=3; IntAct=EBI-714135, EBI-5278764;
CC O75558; Q86X02: CDR2L; NbExp=3; IntAct=EBI-714135, EBI-11063830;
CC O75558; Q96A83-2: COL26A1; NbExp=3; IntAct=EBI-714135, EBI-21553822;
CC O75558; P02489: CRYAA; NbExp=3; IntAct=EBI-714135, EBI-6875961;
CC O75558; P53673: CRYBA4; NbExp=3; IntAct=EBI-714135, EBI-7519711;
CC O75558; Q2TBE0: CWF19L2; NbExp=3; IntAct=EBI-714135, EBI-5453285;
CC O75558; Q9NRI5-2: DISC1; NbExp=4; IntAct=EBI-714135, EBI-11988027;
CC O75558; O75190-2: DNAJB6; NbExp=3; IntAct=EBI-714135, EBI-12593112;
CC O75558; P50570-2: DNM2; NbExp=3; IntAct=EBI-714135, EBI-10968534;
CC O75558; Q68J44: DUSP29; NbExp=3; IntAct=EBI-714135, EBI-1054321;
CC O75558; Q8N9N8: EIF1AD; NbExp=6; IntAct=EBI-714135, EBI-750700;
CC O75558; Q13144: EIF2B5; NbExp=3; IntAct=EBI-714135, EBI-4401110;
CC O75558; Q9BQ89: FAM110A; NbExp=3; IntAct=EBI-714135, EBI-1752811;
CC O75558; Q3B820: FAM161A; NbExp=3; IntAct=EBI-714135, EBI-719941;
CC O75558; Q96MY7: FAM161B; NbExp=3; IntAct=EBI-714135, EBI-7225287;
CC O75558; Q5TZK3: FAM74A6; NbExp=3; IntAct=EBI-714135, EBI-10247271;
CC O75558; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-714135, EBI-6658203;
CC O75558; O95363: FARS2; NbExp=3; IntAct=EBI-714135, EBI-2513774;
CC O75558; O14908-2: GIPC1; NbExp=3; IntAct=EBI-714135, EBI-25913156;
CC O75558; Q53GS7: GLE1; NbExp=3; IntAct=EBI-714135, EBI-1955541;
CC O75558; Q0D2H9: GOLGA8DP; NbExp=3; IntAct=EBI-714135, EBI-10181276;
CC O75558; Q08AF8: GOLGA8G; NbExp=3; IntAct=EBI-714135, EBI-10181260;
CC O75558; Q96CS2: HAUS1; NbExp=3; IntAct=EBI-714135, EBI-2514791;
CC O75558; O14964: HGS; NbExp=3; IntAct=EBI-714135, EBI-740220;
CC O75558; P49639: HOXA1; NbExp=3; IntAct=EBI-714135, EBI-740785;
CC O75558; Q9UKT9: IKZF3; NbExp=3; IntAct=EBI-714135, EBI-747204;
CC O75558; Q92993: KAT5; NbExp=6; IntAct=EBI-714135, EBI-399080;
CC O75558; Q7L273: KCTD9; NbExp=3; IntAct=EBI-714135, EBI-4397613;
CC O75558; Q9BVG8-5: KIFC3; NbExp=7; IntAct=EBI-714135, EBI-14069005;
CC O75558; Q6P597: KLC3; NbExp=3; IntAct=EBI-714135, EBI-1643885;
CC O75558; O14901: KLF11; NbExp=3; IntAct=EBI-714135, EBI-948266;
CC O75558; Q92876: KLK6; NbExp=3; IntAct=EBI-714135, EBI-2432309;
CC O75558; O95678: KRT75; NbExp=3; IntAct=EBI-714135, EBI-2949715;
CC O75558; Q96BZ8: LENG1; NbExp=3; IntAct=EBI-714135, EBI-726510;
CC O75558; Q17RB8: LONRF1; NbExp=3; IntAct=EBI-714135, EBI-2341787;
CC O75558; Q96A72: MAGOHB; NbExp=3; IntAct=EBI-714135, EBI-746778;
CC O75558; Q8WWY6: MBD3L1; NbExp=3; IntAct=EBI-714135, EBI-12516603;
CC O75558; Q9NS73-5: MBIP; NbExp=3; IntAct=EBI-714135, EBI-10182361;
CC O75558; P51608: MECP2; NbExp=3; IntAct=EBI-714135, EBI-1189067;
CC O75558; P50222: MEOX2; NbExp=3; IntAct=EBI-714135, EBI-748397;
CC O75558; P55081: MFAP1; NbExp=3; IntAct=EBI-714135, EBI-1048159;
CC O75558; Q9UJV3-2: MID2; NbExp=3; IntAct=EBI-714135, EBI-10172526;
CC O75558; Q9NYP9: MIS18A; NbExp=3; IntAct=EBI-714135, EBI-1104552;
CC O75558; O14777: NDC80; NbExp=3; IntAct=EBI-714135, EBI-715849;
CC O75558; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-714135, EBI-741158;
CC O75558; Q13153: PAK1; NbExp=3; IntAct=EBI-714135, EBI-1307;
CC O75558; Q16512: PKN1; NbExp=3; IntAct=EBI-714135, EBI-602382;
CC O75558; D3DTS7: PMP22; NbExp=3; IntAct=EBI-714135, EBI-25882629;
CC O75558; Q6NYC8: PPP1R18; NbExp=6; IntAct=EBI-714135, EBI-2557469;
CC O75558; O43741: PRKAB2; NbExp=4; IntAct=EBI-714135, EBI-1053424;
CC O75558; Q99633: PRPF18; NbExp=3; IntAct=EBI-714135, EBI-2798416;
CC O75558; Q8WWY3: PRPF31; NbExp=6; IntAct=EBI-714135, EBI-1567797;
CC O75558; O75771: RAD51D; NbExp=3; IntAct=EBI-714135, EBI-1055693;
CC O75558; A0A0S2Z4G9: RNF6; NbExp=3; IntAct=EBI-714135, EBI-16428950;
CC O75558; O76064: RNF8; NbExp=6; IntAct=EBI-714135, EBI-373337;
CC O75558; Q15287: RNPS1; NbExp=3; IntAct=EBI-714135, EBI-395959;
CC O75558; Q06455-4: RUNX1T1; NbExp=3; IntAct=EBI-714135, EBI-10224192;
CC O75558; Q9BWG6: SCNM1; NbExp=5; IntAct=EBI-714135, EBI-748391;
CC O75558; Q9H788: SH2D4A; NbExp=3; IntAct=EBI-714135, EBI-747035;
CC O75558; Q92529: SHC3; NbExp=3; IntAct=EBI-714135, EBI-79084;
CC O75558; Q9BRV8: SIKE1; NbExp=3; IntAct=EBI-714135, EBI-1773646;
CC O75558; Q969G3: SMARCE1; NbExp=3; IntAct=EBI-714135, EBI-455078;
CC O75558; A8K287: SNAP23; NbExp=3; IntAct=EBI-714135, EBI-10188497;
CC O75558; O00161: SNAP23; NbExp=10; IntAct=EBI-714135, EBI-745000;
CC O75558; P60880-2: SNAP25; NbExp=3; IntAct=EBI-714135, EBI-12177361;
CC O75558; O94964-4: SOGA1; NbExp=3; IntAct=EBI-714135, EBI-14083835;
CC O75558; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-714135, EBI-5235340;
CC O75558; Q16623: STX1A; NbExp=3; IntAct=EBI-714135, EBI-712466;
CC O75558; Q12846: STX4; NbExp=3; IntAct=EBI-714135, EBI-744942;
CC O75558; P61764: STXBP1; NbExp=6; IntAct=EBI-714135, EBI-960169;
CC O75558; Q15833: STXBP2; NbExp=4; IntAct=EBI-714135, EBI-4401015;
CC O75558; O75528: TADA3; NbExp=3; IntAct=EBI-714135, EBI-473249;
CC O75558; Q15560: TCEA2; NbExp=3; IntAct=EBI-714135, EBI-710310;
CC O75558; P15884: TCF4; NbExp=3; IntAct=EBI-714135, EBI-533224;
CC O75558; Q08117: TLE5; NbExp=3; IntAct=EBI-714135, EBI-717810;
CC O75558; Q08117-2: TLE5; NbExp=3; IntAct=EBI-714135, EBI-11741437;
CC O75558; O14656-2: TOR1A; NbExp=3; IntAct=EBI-714135, EBI-25847109;
CC O75558; Q8WV44: TRIM41; NbExp=3; IntAct=EBI-714135, EBI-725997;
CC O75558; Q3SY00: TSGA10IP; NbExp=3; IntAct=EBI-714135, EBI-10241197;
CC O75558; P57075-2: UBASH3A; NbExp=3; IntAct=EBI-714135, EBI-7353612;
CC O75558; Q8N6Y0: USHBP1; NbExp=3; IntAct=EBI-714135, EBI-739895;
CC O75558; Q8N1B4: VPS52; NbExp=3; IntAct=EBI-714135, EBI-2799833;
CC O75558; Q8TBK6: ZCCHC10; NbExp=4; IntAct=EBI-714135, EBI-597063;
CC O75558; P17023: ZNF19; NbExp=3; IntAct=EBI-714135, EBI-12884200;
CC O75558; Q8TAU3: ZNF417; NbExp=6; IntAct=EBI-714135, EBI-740727;
CC O75558; Q96SQ5: ZNF587; NbExp=8; IntAct=EBI-714135, EBI-6427977;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Peripheral membrane
CC protein {ECO:0000305}. Golgi apparatus, trans-Golgi network membrane
CC {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
CC -!- DISEASE: Hemophagocytic lymphohistiocytosis, familial, 4 (FHL4)
CC [MIM:603552]: A rare disorder characterized by immune dysregulation
CC with hypercytokinemia, defective function of natural killer cell, and
CC massive infiltration of several organs by activated lymphocytes and
CC macrophages. The clinical features of the disease include fever,
CC hepatosplenomegaly, cytopenia, and less frequently neurological
CC abnormalities ranging from irritability and hypotonia to seizures,
CC cranial nerve deficits and ataxia. {ECO:0000269|PubMed:15703195}.
CC Note=The disease is caused by variants affecting the gene represented
CC in this entry.
CC -!- SIMILARITY: Belongs to the syntaxin family. {ECO:0000305}.
CC -!- WEB RESOURCE: Name=STX11base; Note=STX11 mutation db;
CC URL="http://structure.bmc.lu.se/idbase/STX11base/";
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DR EMBL; AF038898; AAD02107.1; -; mRNA.
DR EMBL; AF044309; AAC24031.1; -; mRNA.
DR EMBL; AF071504; AAC24004.1; -; mRNA.
DR EMBL; AL135917; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471051; EAW47849.1; -; Genomic_DNA.
DR EMBL; CH471051; EAW47850.1; -; Genomic_DNA.
DR EMBL; BC033519; AAH33519.1; -; mRNA.
DR CCDS; CCDS5205.1; -.
DR PIR; JE0094; JE0094.
DR RefSeq; NP_003755.2; NM_003764.3.
DR RefSeq; XP_011534516.1; XM_011536214.2.
DR RefSeq; XP_011534519.1; XM_011536217.2.
DR RefSeq; XP_011534520.1; XM_011536218.2.
DR RefSeq; XP_016866889.1; XM_017011400.1.
DR AlphaFoldDB; O75558; -.
DR SMR; O75558; -.
DR BioGRID; 114224; 146.
DR CORUM; O75558; -.
DR IntAct; O75558; 153.
DR MINT; O75558; -.
DR STRING; 9606.ENSP00000356540; -.
DR iPTMnet; O75558; -.
DR PhosphoSitePlus; O75558; -.
DR SwissPalm; O75558; -.
DR BioMuta; STX11; -.
DR OGP; O75558; -.
DR EPD; O75558; -.
DR jPOST; O75558; -.
DR MassIVE; O75558; -.
DR MaxQB; O75558; -.
DR PaxDb; O75558; -.
DR PeptideAtlas; O75558; -.
DR PRIDE; O75558; -.
DR ProteomicsDB; 50085; -.
DR Antibodypedia; 714; 194 antibodies from 28 providers.
DR DNASU; 8676; -.
DR Ensembl; ENST00000367568.5; ENSP00000356540.4; ENSG00000135604.10.
DR GeneID; 8676; -.
DR KEGG; hsa:8676; -.
DR MANE-Select; ENST00000367568.5; ENSP00000356540.4; NM_003764.4; NP_003755.2.
DR UCSC; uc003qks.5; human.
DR CTD; 8676; -.
DR DisGeNET; 8676; -.
DR GeneCards; STX11; -.
DR GeneReviews; STX11; -.
DR HGNC; HGNC:11429; STX11.
DR HPA; ENSG00000135604; Tissue enhanced (bone).
DR MalaCards; STX11; -.
DR MIM; 603552; phenotype.
DR MIM; 605014; gene.
DR neXtProt; NX_O75558; -.
DR OpenTargets; ENSG00000135604; -.
DR Orphanet; 540; Familial hemophagocytic lymphohistiocytosis.
DR PharmGKB; PA36229; -.
DR VEuPathDB; HostDB:ENSG00000135604; -.
DR eggNOG; KOG0810; Eukaryota.
DR GeneTree; ENSGT01050000244948; -.
DR HOGENOM; CLU_042423_2_0_1; -.
DR InParanoid; O75558; -.
DR OMA; PCKKLFC; -.
DR OrthoDB; 1033833at2759; -.
DR PhylomeDB; O75558; -.
DR TreeFam; TF313763; -.
DR PathwayCommons; O75558; -.
DR SignaLink; O75558; -.
DR SIGNOR; O75558; -.
DR BioGRID-ORCS; 8676; 8 hits in 1071 CRISPR screens.
DR GeneWiki; STX11; -.
DR GenomeRNAi; 8676; -.
DR Pharos; O75558; Tbio.
DR PRO; PR:O75558; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; O75558; protein.
DR Bgee; ENSG00000135604; Expressed in monocyte and 125 other tissues.
DR Genevisible; O75558; HS.
DR GO; GO:0012505; C:endomembrane system; IBA:GO_Central.
DR GO; GO:0005794; C:Golgi apparatus; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0048787; C:presynaptic active zone membrane; IBA:GO_Central.
DR GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR GO; GO:0008021; C:synaptic vesicle; IBA:GO_Central.
DR GO; GO:0005484; F:SNAP receptor activity; IBA:GO_Central.
DR GO; GO:0000149; F:SNARE binding; IBA:GO_Central.
DR GO; GO:0006887; P:exocytosis; IBA:GO_Central.
DR GO; GO:0006886; P:intracellular protein transport; IBA:GO_Central.
DR GO; GO:0061025; P:membrane fusion; TAS:ProtInc.
DR GO; GO:0031629; P:synaptic vesicle fusion to presynaptic active zone membrane; IBA:GO_Central.
DR GO; GO:0048278; P:vesicle docking; IBA:GO_Central.
DR GO; GO:0006906; P:vesicle fusion; IBA:GO_Central.
DR CDD; cd15878; SNARE_syntaxin11; 1.
DR CDD; cd00179; SynN; 1.
DR InterPro; IPR010989; SNARE.
DR InterPro; IPR028672; STX11.
DR InterPro; IPR045242; Syntaxin.
DR InterPro; IPR006012; Syntaxin/epimorphin_CS.
DR InterPro; IPR042781; Syntaxin11_SNARE.
DR InterPro; IPR006011; Syntaxin_N.
DR InterPro; IPR000727; T_SNARE_dom.
DR PANTHER; PTHR19957; PTHR19957; 1.
DR PANTHER; PTHR19957:SF30; PTHR19957:SF30; 1.
DR Pfam; PF00804; Syntaxin; 1.
DR SMART; SM00503; SynN; 1.
DR SMART; SM00397; t_SNARE; 1.
DR SUPFAM; SSF47661; SSF47661; 1.
DR PROSITE; PS00914; SYNTAXIN; 1.
DR PROSITE; PS50192; T_SNARE; 1.
PE 1: Evidence at protein level;
KW Coiled coil; Familial hemophagocytic lymphohistiocytosis; Golgi apparatus;
KW Membrane; Protein transport; Reference proteome; Transport.
FT CHAIN 1..287
FT /note="Syntaxin-11"
FT /id="PRO_0000210221"
FT DOMAIN 204..266
FT /note="t-SNARE coiled-coil homology"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00202"
FT COILED 41..71
FT /evidence="ECO:0000255"
FT VARIANT 31
FT /note="E -> Q (in dbSNP:rs1802414)"
FT /id="VAR_011995"
FT VARIANT 49
FT /note="R -> Q (in dbSNP:rs17073498)"
FT /id="VAR_029769"
FT VARIANT 204
FT /note="L -> H (in dbSNP:rs1133248)"
FT /id="VAR_011996"
FT VARIANT 277
FT /note="T -> A (in dbSNP:rs9496891)"
FT /id="VAR_029770"
FT CONFLICT 61
FT /note="D -> N (in Ref. 1; AAD02107)"
FT /evidence="ECO:0000305"
FT CONFLICT 93..94
FT /note="IK -> FR (in Ref. 2; AAC24031)"
FT /evidence="ECO:0000305"
FT CONFLICT 96..97
FT /note="RG -> PP (in Ref. 1; AAD02107)"
FT /evidence="ECO:0000305"
FT CONFLICT 103..104
FT /note="KL -> NV (in Ref. 1; AAD02107)"
FT /evidence="ECO:0000305"
FT CONFLICT 121..126
FT /note="HSAVAR -> ALGSGG (in Ref. 1; AAD02107)"
FT /evidence="ECO:0000305"
FT CONFLICT 200..220
FT /note="ARAALNEIESRHRELLRLESR -> RGPPTTRSRAATANCCAWRAA (in
FT Ref. 2; AAC24031)"
FT /evidence="ECO:0000305"
FT CONFLICT 200
FT /note="A -> V (in Ref. 1; AAD02107)"
FT /evidence="ECO:0000305"
FT CONFLICT 215
FT /note="L -> V (in Ref. 1; AAD02107)"
FT /evidence="ECO:0000305"
FT CONFLICT 220
FT /note="R -> A (in Ref. 1; AAD02107)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 287 AA; 33196 MW; 18E8B43BA987D891 CRC64;
MKDRLAELLD LSKQYDQQFP DGDDEFDSPH EDIVFETDHI LESLYRDIRD IQDENQLLVA
DVKRLGKQNA RFLTSMRRLS SIKRDTNSIA KAIKARGEVI HCKLRAMKEL SEAAEAQHGP
HSAVARISRA QYNALTLTFQ RAMHDYNQAE MKQRDNCKIR IQRQLEIMGK EVSGDQIEDM
FEQGKWDVFS ENLLADVKGA RAALNEIESR HRELLRLESR IRDVHELFLQ MAVLVEKQAD
TLNVIELNVQ KTVDYTGQAK AQVRKAVQYE EKNPCRTLCC FCCPCLK
