ID   STX18_DANRE             Reviewed;         314 AA.
AC   Q4VBI7;
DT   16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 91.
DE   RecName: Full=Syntaxin-18;
GN   Name=stx18 {ECO:0000250|UniProtKB:Q9P2W9}; ORFNames=zgc:112326;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1] {ECO:0000312|EMBL:AAH95763.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye {ECO:0000312|EMBL:AAH95763.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Syntaxin that may be involved in targeting and fusion of
CC       Golgi-derived retrograde transport vesicles with the ER.
CC       {ECO:0000250|UniProtKB:Q9P2W9}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass type IV membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the syntaxin family. {ECO:0000305}.
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DR   EMBL; BC095763; AAH95763.1; -; mRNA.
DR   RefSeq; NP_001019596.1; NM_001024425.1.
DR   AlphaFoldDB; Q4VBI7; -.
DR   SMR; Q4VBI7; -.
DR   STRING; 7955.ENSDARP00000051892; -.
DR   Ensembl; ENSDART00000051893; ENSDARP00000051892; ENSDARG00000035763.
DR   GeneID; 554130; -.
DR   KEGG; dre:554130; -.
DR   CTD; 53407; -.
DR   ZFIN; ZDB-GENE-050522-397; stx18.
DR   GeneTree; ENSGT00390000014853; -.
DR   HOGENOM; CLU_071402_1_0_1; -.
DR   InParanoid; Q4VBI7; -.
DR   OMA; WEESRVE; -.
DR   OrthoDB; 1141750at2759; -.
DR   PhylomeDB; Q4VBI7; -.
DR   Reactome; R-DRE-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR   PRO; PR:Q4VBI7; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 14.
DR   Bgee; ENSDARG00000035763; Expressed in tail and 22 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR   GO; GO:0005484; F:SNAP receptor activity; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; IBA:GO_Central.
DR   InterPro; IPR019529; Syntaxin-18_N.
DR   InterPro; IPR006012; Syntaxin/epimorphin_CS.
DR   Pfam; PF10496; Syntaxin-18_N; 1.
DR   PROSITE; PS00914; SYNTAXIN; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Endoplasmic reticulum; ER-Golgi transport; Membrane;
KW   Protein transport; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport.
FT   CHAIN           1..314
FT                   /note="Syntaxin-18"
FT                   /id="PRO_0000235907"
FT   TOPO_DOM        1..288
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        289..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        310..314
FT                   /note="Lumenal"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          222..284
FT                   /note="t-SNARE coiled-coil homology"
FT                   /evidence="ECO:0000255"
FT   REGION          24..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          170..196
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        32..48
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   314 AA;  36241 MW;  66D63DEAB497CB1E CRC64;
     MAADITLLFK ASVKTVKTRN KALGLMETTG REEPGAQKRP RPRQRDSFSC KAREVISNIS
     KLKDFLLQHR KDYVNAGSVM SSEVSRMTDS ERDQIDQDAQ IFMRTCAEAI SQLRSEMDKK
     QVSMQVKDHR AAVLDLIDSY LKGVCKLYSE QRAVRVKRVV DKKRLSRLEP EQINTEKRQS
     DGEENDKPVS DGNVDLWEEN RVEDDLSPEE IQMFEQENQR LVGEMNSLLD EVRQIEGKVV
     EISRLQEIFS EKVLQQETEI DSIHQLVVGA TENVKEGNED IREAIKNNAG FRVWILFFLV
     MCSFSLLFLD WYDS