ID   STX18_PONAB             Reviewed;         335 AA.
AC   Q5REB4;
DT   07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Syntaxin-18;
GN   Name=STX18;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Syntaxin that may be involved in targeting and fusion of
CC       Golgi-derived retrograde transport vesicles with the ER. {ECO:0000250}.
CC   -!- SUBUNIT: Component of a SNARE complex consisting of STX18, USE1L,
CC       BNIP1/SEC20L, and SEC22B. RINT1/TIP20L and ZW10 are associated with the
CC       complex through interaction with BNIP1/SEC20L. Interacts directly with
CC       USE1L and BNIP1/SEC20L (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass type IV membrane protein {ECO:0000250}. Golgi apparatus
CC       membrane {ECO:0000305}; Single-pass type IV membrane protein
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the syntaxin family. {ECO:0000305}.
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DR   EMBL; CR857618; CAH89893.1; -; mRNA.
DR   RefSeq; NP_001124885.1; NM_001131413.1.
DR   AlphaFoldDB; Q5REB4; -.
DR   SMR; Q5REB4; -.
DR   STRING; 9601.ENSPPYP00000016308; -.
DR   GeneID; 100441033; -.
DR   KEGG; pon:100441033; -.
DR   CTD; 53407; -.
DR   eggNOG; KOG3894; Eukaryota.
DR   InParanoid; Q5REB4; -.
DR   OrthoDB; 1141750at2759; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005484; F:SNAP receptor activity; IEA:InterPro.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
DR   InterPro; IPR019529; Syntaxin-18_N.
DR   InterPro; IPR006012; Syntaxin/epimorphin_CS.
DR   Pfam; PF10496; Syntaxin-18_N; 1.
DR   PROSITE; PS00914; SYNTAXIN; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus;
KW   Membrane; Protein transport; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..335
FT                   /note="Syntaxin-18"
FT                   /id="PRO_0000210233"
FT   TOPO_DOM        1..309
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        310..330
FT                   /note="Helical; Anchor for type IV membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        331..335
FT                   /note="Vesicular"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          243..305
FT                   /note="t-SNARE coiled-coil homology"
FT   REGION          168..226
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        168..209
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   335 AA;  38702 MW;  D8980B601DDC1A6F CRC64;
     MAVDITLLFR ASVKTVKTRN KALGVAVGGG VDGSRDELFR RSPRPKGDFS SRAREVISHI
     GKLRDFLLEH RKDYINAYSH TMSEYGRMTD TERDQIDQDA QIFMRTCSEA IQQLRTEAHK
     EIHSQQVKEH RTAVLDFIED YLKRVCKLYS EQRAIRVKRV VDKKRLSKLE PEPNTKTRES
     TSSEKVSRSP SKDSEENPAT EERPEKILAE TQPELGTWGD GKGEDELSPE EIQMFEQENQ
     RLIGEMNSLF DEVRQIEGRV VEISRLQEIF TEKVLQQEAE IDSIHQLVVG ATENIKEGNE
     DIREAIKNNA GFRVWILFFL VMCSFSLLFL DWYDS