ID   STX18_RAT               Reviewed;         334 AA.
AC   Q68FW4;
DT   07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 114.
DE   RecName: Full=Syntaxin-18;
GN   Name=Stx18;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: Syntaxin that may be involved in targeting and fusion of
CC       Golgi-derived retrograde transport vesicles with the ER. {ECO:0000250}.
CC   -!- SUBUNIT: Component of a SNARE complex consisting of STX18, USE1L,
CC       BNIP1/SEC20L, and SEC22B. RINT1/TIP20L and ZW10 are associated with the
CC       complex through interaction with BNIP1/SEC20L. Interacts directly with
CC       USE1L and BNIP1/SEC20L (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane {ECO:0000250};
CC       Single-pass type IV membrane protein {ECO:0000250}. Golgi apparatus
CC       membrane {ECO:0000305}; Single-pass type IV membrane protein
CC       {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the syntaxin family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC079183; AAH79183.1; -; mRNA.
DR   RefSeq; NP_001012151.1; NM_001012151.1.
DR   AlphaFoldDB; Q68FW4; -.
DR   CORUM; Q68FW4; -.
DR   IntAct; Q68FW4; 6.
DR   STRING; 10116.ENSRNOP00000008410; -.
DR   jPOST; Q68FW4; -.
DR   PaxDb; Q68FW4; -.
DR   PRIDE; Q68FW4; -.
DR   Ensembl; ENSRNOT00000095745; ENSRNOP00000082982; ENSRNOG00000006139.
DR   GeneID; 360953; -.
DR   KEGG; rno:360953; -.
DR   CTD; 53407; -.
DR   RGD; 1310058; Stx18.
DR   eggNOG; KOG3894; Eukaryota.
DR   GeneTree; ENSGT00390000014853; -.
DR   HOGENOM; CLU_071402_1_0_1; -.
DR   InParanoid; Q68FW4; -.
DR   OMA; WEESRVE; -.
DR   OrthoDB; 1141750at2759; -.
DR   PhylomeDB; Q68FW4; -.
DR   TreeFam; TF105868; -.
DR   Reactome; R-RNO-6811434; COPI-dependent Golgi-to-ER retrograde traffic.
DR   PRO; PR:Q68FW4; -.
DR   Proteomes; UP000002494; Chromosome 14.
DR   Bgee; ENSRNOG00000006139; Expressed in testis and 20 other tissues.
DR   Genevisible; Q68FW4; RN.
DR   GO; GO:0005783; C:endoplasmic reticulum; ISO:RGD.
DR   GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0031201; C:SNARE complex; IBA:GO_Central.
DR   GO; GO:0019904; F:protein domain specific binding; ISO:RGD.
DR   GO; GO:0005484; F:SNAP receptor activity; IEA:InterPro.
DR   GO; GO:0090158; P:endoplasmic reticulum membrane organization; ISO:RGD.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   GO; GO:1902953; P:positive regulation of ER to Golgi vesicle-mediated transport; ISO:RGD.
DR   GO; GO:1902117; P:positive regulation of organelle assembly; ISO:RGD.
DR   GO; GO:1903358; P:regulation of Golgi organization; ISO:RGD.
DR   GO; GO:0006890; P:retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; IBA:GO_Central.
DR   InterPro; IPR019529; Syntaxin-18_N.
DR   InterPro; IPR006012; Syntaxin/epimorphin_CS.
DR   Pfam; PF10496; Syntaxin-18_N; 1.
DR   PROSITE; PS00914; SYNTAXIN; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Endoplasmic reticulum; ER-Golgi transport; Golgi apparatus;
KW   Membrane; Protein transport; Reference proteome; Transmembrane;
KW   Transmembrane helix; Transport.
FT   CHAIN           1..334
FT                   /note="Syntaxin-18"
FT                   /id="PRO_0000210234"
FT   TOPO_DOM        1..308
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        309..329
FT                   /note="Helical; Anchor for type IV membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        330..334
FT                   /note="Vesicular"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          242..304
FT                   /note="t-SNARE coiled-coil homology"
FT   REGION          29..50
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          166..225
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        34..50
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        166..207
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   334 AA;  38512 MW;  98CB261E598BFF84 CRC64;
     MAVDITLLFR ASVKTVKTRN KALGVAVGGG ADGSRDELFR RSPRPKGDFS SRAREVISHI
     GKLRDFLLEH RKEYINAYSH TMSEYGRMTD TERDQIDQDA QIFMRTCKDA IQQLRTEAHK
     EIHSQQVKEH RTAVLDFVED YLKRVCKLYS EQRAIRVKRV VDKKRLSKLE PEPHTKRKEP
     ASEKSSHNAS QDSEEKPAAE DLPEKPLAES QPELGTWGDG KGEDELSPEE IQMFEQENQR
     LIGEMNSLFD EVRQIEGKVV EISRLQEIFT EKVLQQETEI DSIHQLVVGA TENIKEGNED
     IREAIKNNAG FRVWILFFLV MCSFSLLFLD WYDS